Outputs (2320)

Key phosphorylation sites for robust β-arrestin2 binding at the MOR revisited (2024)
Journal Article
Underwood, O., Fritzwanker, S., Glenn, J., Blum, N. K., Batista-Gondin, A., Drube, J., Hoffmann, C., Briddon, S. J., Schulz, S., & Canals, M. (2024). Key phosphorylation sites for robust β-arrestin2 binding at the MOR revisited. Communications Biology, 7, Article 933. https://doi.org/10.1038/s42003-024-06571-1

Desensitisation of the mu-opioid receptor (MOR) is proposed to underlie the initiation of opioid analgesic tolerance and previous work has shown that agonist-induced phosphorylation of the MOR C-tail contributes to this desensitisation. Moreover, pho... Read More about Key phosphorylation sites for robust β-arrestin2 binding at the MOR revisited.

The limit to evolutionary rescue depends on ploidy in yeast exposed to nystatin (2024)
Journal Article
Ono, J., Kuzmin, A., Miller, L., & Otto, S. P. (2024). The limit to evolutionary rescue depends on ploidy in yeast exposed to nystatin. Canadian Journal of Microbiology, https://doi.org/10.1139/cjm-2023-0235

The number of copies of each chromosome, or ploidy, of an organism is a major genomic factor affecting adaptation. We set out to determine how ploidy can impact the outcome of evolution, as well as the likelihood of evolutionary rescue, using short-t... Read More about The limit to evolutionary rescue depends on ploidy in yeast exposed to nystatin.

Quantitative BOLD (qBOLD) imaging of oxygen metabolism and blood oxygenation in the human body: A scoping review (2024)
Journal Article
Alzaidi, A. A., Panek, R., & Blockley, N. P. (2024). Quantitative BOLD (qBOLD) imaging of oxygen metabolism and blood oxygenation in the human body: A scoping review. Magnetic Resonance in Medicine, https://doi.org/10.1002/mrm.30165

Purpose There are many approaches to the quantitative BOLD (qBOLD) technique described in the literature, differing in pulse sequences, MRI parameters and data processing. Thus, in this review, we summarized the acquisition methods, approaches used... Read More about Quantitative BOLD (qBOLD) imaging of oxygen metabolism and blood oxygenation in the human body: A scoping review.

Development of resident and migratory three-spined stickleback, Gasterosteus aculeatus (2024)
Journal Article
Barnes, M., Chakrabarti, L., & MacColl, A. D. C. (2024). Development of resident and migratory three-spined stickleback, Gasterosteus aculeatus. PLoS ONE, 19(7), Article e0295485. https://doi.org/10.1371/journal.pone.0295485

The three-spined stickleback (Gasterosteus aculeatus) is a teleost fish and a model organism in evolutionary ecology, useful for both laboratory and natural experiments. It is especially valued for the substantial intraspecific variation in morpholog... Read More about Development of resident and migratory three-spined stickleback, Gasterosteus aculeatus.

Altered oxidative neurometabolic response to methylene blue in bipolar disorder revealed by quantitative neuroimaging (2024)
Journal Article
Russo, A., Örzsik, B., Yalin, N., Simpson, I., Nwaubani, P., Pinna, A., De Marco, R., Sharp, H., Kartar, A., Singh, N., Blockley, N., Stone, A. J. L., Turkheimer, F. E., Young, A. H., Cercignani, M., Zelaya, F., Asllani, I., & Colasanti, A. (2024). Altered oxidative neurometabolic response to methylene blue in bipolar disorder revealed by quantitative neuroimaging. Journal of Affective Disorders, 362, 790-798. https://doi.org/10.1016/j.jad.2024.07.029

Background: Cerebral mitochondrial and hemodynamic abnormalities have been implicated in Bipolar Disorder pathophysiology, likely contributing to neurometabolic vulnerability–leading to worsen clinical outcomes and mood instability. To investigate ne... Read More about Altered oxidative neurometabolic response to methylene blue in bipolar disorder revealed by quantitative neuroimaging.

Ligand-Directed Labeling of the Adenosine A1 Receptor in Living Cells (2024)
Journal Article
Comeo, E., Goulding, J., Lin, C.-Y., Groenen, M., Woolard, J., Kindon, N. D., Harwood, C. R., Platt, S., Briddon, S. J., Kilpatrick, L. E., Scammells, P. J., Hill, S. J., & Kellam, B. (2024). Ligand-Directed Labeling of the Adenosine A1 Receptor in Living Cells. Journal of Medicinal Chemistry, 67(14), 12099–12117. https://doi.org/10.1021/acs.jmedchem.4c00835

The study of protein function and dynamics in their native cellular environment is essential for progressing fundamental science. To overcome the requirement of genetic modification of the protein or the limitations of dissociable fluorescent ligands... Read More about Ligand-Directed Labeling of the Adenosine A1 Receptor in Living Cells.

Multi-day neuron tracking in high-density electrophysiology recordings using earth mover's distance (2024)
Journal Article
Yuan, A., Colonell, J., Lebedeva, A., Okun, M., Charles, A., & Harris, T. D. (2024). Multi-day neuron tracking in high-density electrophysiology recordings using earth mover's distance. eLife, 12, Article 92495. https://doi.org/10.7554/eLife.92495.3

Accurate tracking of the same neurons across multiple days is crucial for studying changes in neuronal activity during learning and adaptation. Advances in high-density extracellular electrophysiology recording probes, such as Neuropixels, provide a... Read More about Multi-day neuron tracking in high-density electrophysiology recordings using earth mover's distance.

Sorting of GPI-anchored proteins at the trypanosome surface is independent of GPI insertion signals (2024)
Journal Article
Miller, T. H., Schiessler, S., Rogerson, E. M., & Gadelha, C. (2024). Sorting of GPI-anchored proteins at the trypanosome surface is independent of GPI insertion signals. The Cell Surface, 12, Article 100131. https://doi.org/10.1016/j.tcsw.2024.100131

The segregation of glycosylphosphatidylinositol-anchored proteins (GPI-APs) to distinct domains on the plasma membrane of eukaryotic cells is important for their correct cellular function, but the mechanisms by which GPI-APs are sorted are yet to be... Read More about Sorting of GPI-anchored proteins at the trypanosome surface is independent of GPI insertion signals.

How does viewing angle affect the perceived accuracy of Batesian mimicry in hoverflies? (2024)
Journal Article
Baker, L., Taylor, C., Gilbert, F., & Reader, T. (2024). How does viewing angle affect the perceived accuracy of Batesian mimicry in hoverflies?. Behavioral Ecology, 35(5), Article arae054. https://doi.org/10.1093/beheco/arae054

Despite Batesian mimicry often eliciting predator avoidance, many Batesian mimics, such as some species of hoverfly (Syrphidae), are considered to have an “imperfect” resemblance to their model. One possible explanation for the persistence of apparen... Read More about How does viewing angle affect the perceived accuracy of Batesian mimicry in hoverflies?.

Reconstruction of the historic time course of blood‐borne virus contamination of clotting factor concentrates, 1974–1992 (2024)
Journal Article
McClure, C. P., Kean, K., Reid, K., Mayne, R., Fu, M. X., Rajendra, P., …Simmonds, P. (2024). Reconstruction of the historic time course of blood‐borne virus contamination of clotting factor concentrates, 1974–1992. Journal of Medical Virology, 96(7), Article e29774. https://doi.org/10.1002/jmv.29774

Factor VIII and IX clotting factor concentrates manufactured from pooled plasma have been identified as potent sources of virus infection in persons with hemophilia (PWHs) in the 1970s and 1980s. To investigate the range and diversity of viruses over... Read More about Reconstruction of the historic time course of blood‐borne virus contamination of clotting factor concentrates, 1974–1992.