Outputs (2373)

Structuring white rice with gellan gum reduces the glycemic response in healthy humans (2024)
Journal Article
Alshammari, N. A., Riches, K., Muttakin, S., Hoad, C. L., Strkalj, L., Gouseti, O., Bakalis, S., Lovegrove, A., Spiller, R. C., Gowland, P. A., Aithal, G. P., Yakubov, G. E., Taylor, M. A., & Marciani, L. (2024). Structuring white rice with gellan gum reduces the glycemic response in healthy humans. Food Research International, 196, Article 115090. https://doi.org/10.1016/j.foodres.2024.115090

White rice has a high glycemic index and its consumption has been linked to an increased risk of developing type-2 diabetes mellitus, increased diabetes associated complications and obesity. In recent in vitro studies we have shown that addition of f... Read More about Structuring white rice with gellan gum reduces the glycemic response in healthy humans.

Dually Labeled Neurotensin NTS1R Ligands for Probing Radiochemical and Fluorescence-Based Binding Assays (2024)
Journal Article
Ertl, F. J., Kopanchuk, S., Dijon, N. C., Veikšina, S., Tahk, M.-J., Laasfeld, T., Schettler, F., Gattor, A. O., Hübner, H., Archipowa, N., Köckenberger, J., Heinrich, M. R., Gmeiner, P., Kutta, R. J., Holliday, N. D., Rinken, A., & Keller, M. (2024). Dually Labeled Neurotensin NTS1R Ligands for Probing Radiochemical and Fluorescence-Based Binding Assays. Journal of Medicinal Chemistry, 67(18), 16664-16691. https://doi.org/10.1021/acs.jmedchem.4c01470

The determination of ligand-receptor binding affinities plays a key role in the development process of pharmaceuticals. While the classical radiochemical binding assay uses radioligands, fluorescence-based binding assays require fluorescent probes. U... Read More about Dually Labeled Neurotensin NTS1R Ligands for Probing Radiochemical and Fluorescence-Based Binding Assays.

Optogenetic control of Drosophila neurons: a laboratory practical for undergraduates and outreach (2024)
Journal Article
Renault, A. D. (in press). Optogenetic control of Drosophila neurons: a laboratory practical for undergraduates and outreach. Journal of Microbiology and Biology Education, https://doi.org/10.1128/jmbe.00086-24

Teaching aspects of neuroscience to large undergraduate classes can be difficult in terms of the cost of equipment involved such as microscopes and electrophysiology equipment, the time taken to master techniques such as dissection or intracellular r... Read More about Optogenetic control of Drosophila neurons: a laboratory practical for undergraduates and outreach.

The human HELQ helicase and XRN2 exoribonuclease cooperate in R-loop resolution (2024)
Journal Article
Pan, J., Betts, H., Cubbon, A., Bolt, E., Soultanas, P., & He, L. (in press). The human HELQ helicase and XRN2 exoribonuclease cooperate in R-loop resolution. Open Biology,

The human HELQ helicase is a superfamily 2, 3’-5’ helicase homologous to POLQ and RNA helicases of the Ski2-like subfamily. It is involved in diverse aspects of DNA repair and is an emerging prognosis biomarker and novel drug-target for cancer therap... Read More about The human HELQ helicase and XRN2 exoribonuclease cooperate in R-loop resolution.

Effects of muscle strength training combined with aerobic training versus aerobic training alone on cardiovascular disease risk indicators in patients with coronary artery disease: a systematic review and meta-analysis of randomised clinical trials (2024)
Journal Article
Terada, T., Pap, R., Thomas, A., Wei, R., Noda, T., Visintini, S., & Reed, J. L. (2024). Effects of muscle strength training combined with aerobic training versus aerobic training alone on cardiovascular disease risk indicators in patients with coronary artery disease: a systematic review and meta-analysis of randomised clinical trials. British Journal of Sports Medicine, 1-10. https://doi.org/10.1136/bjsports-2024-108530

Objective: To compare the effects of aerobic training combined with muscle strength training (hereafter referred to as combined training) to aerobic training alone on cardiovascular disease risk indicators in patients with coronary artery disease (CA... Read More about Effects of muscle strength training combined with aerobic training versus aerobic training alone on cardiovascular disease risk indicators in patients with coronary artery disease: a systematic review and meta-analysis of randomised clinical trials.

Stable Platform for Mevalonate Bioproduction from CO2 (2024)
Journal Article
Garavaglia, M., McGregor, C., Bommareddy, R. R., Irorere, V., Arenas, C., Robazza, A., Minton, N. P., & Kovacs, K. (2024). Stable Platform for Mevalonate Bioproduction from CO2. ACS Sustainable Chemistry and Engineering, 12(36), 13486-13499. https://doi.org/10.1021/acssuschemeng.4c03561

Stable production of value-added products using a microbial chassis is pivotal for determining the industrial suitability of the engineered biocatalyst. Microbial cells often lose the multicopy expression plasmids during long-term cultivations. Owing... Read More about Stable Platform for Mevalonate Bioproduction from CO2.

Natural product pharmacology: the British Journal of Pharmacology perspective (2024)
Journal Article
Wang, X., Izzo, A. A., Papapetropoulos, A., Alexander, S. P. H., Cortese‐Krott, M., Kendall, D. A., Martemyanov, K. A., Mauro, C., Panettieri, R. A., Patel, H. H., Schulz, R., Stefanska, B., Stephens, G. J., Teixeira, M. M., Vergnolle, N., & Ferdinandy, P. (2024). Natural product pharmacology: the British Journal of Pharmacology perspective. British Journal of Pharmacology, https://doi.org/10.1111/bph.17300

Natural products (NPs) have long been used as a rich source of bioactive compounds for drug development. Recent technological advancements have revitalised natural products research as evidenced by increased publications in this field. In this editor... Read More about Natural product pharmacology: the British Journal of Pharmacology perspective.

Determination of hATG8 Binding Selectivity of AIM (Autophagy-Interacting Motif) Peptides Using Native Electrospray Ionization Mass Spectrometry (2024)
Book Chapter
Brennan, A., Oldham, N., Layfield, R., & Scott, D. (2024). Determination of hATG8 Binding Selectivity of AIM (Autophagy-Interacting Motif) Peptides Using Native Electrospray Ionization Mass Spectrometry. In I. P. Nezis (Ed.), Selective autophagy: methods and protocols (237-246). Springer. https://doi.org/10.1007/978-1-0716-4067-8_19

Establishing the hATG8 binding selectivity of AIM (autophagy-interacting motif) sequences found within autophagy system proteins provides insights into their biological roles, and in the case of disease-associated AIM mutations, potential pathophysio... Read More about Determination of hATG8 Binding Selectivity of AIM (Autophagy-Interacting Motif) Peptides Using Native Electrospray Ionization Mass Spectrometry.

Cost-effectiveness of HCC Surveillance Strategies in Patients With Compensated Liver Cirrhosis in the United Kingdom (2024)
Journal Article
Garay, O. U., Ambühl, L. E., Bird, T. G., Barnes, E., Irving, W. L., Walkley, R., & Rowe, I. A. (2024). Cost-effectiveness of HCC Surveillance Strategies in Patients With Compensated Liver Cirrhosis in the United Kingdom. Value in Health, https://doi.org/10.1016/j.jval.2024.07.015

This study aimed to evaluate the cost-effectiveness (CE) of four hepatocellular carcinoma (HCC) surveillance strategies in the UK, the GAAD algorithm, which combines gender (biological sex) and age with Elecsys® biomarker assays, alpha-fetoprotein (A... Read More about Cost-effectiveness of HCC Surveillance Strategies in Patients With Compensated Liver Cirrhosis in the United Kingdom.

Variability of cardiopulmonary exercise testing in patients with atrial fibrillation and determination of exercise responders to high-intensity interval training and moderate-to-vigorous intensity continuous training (2024)
Journal Article
Terada, T., Keir, D. A., Murias, J. M., Vidal-Almela, S., Buckley, J., & Reed, J. L. (2024). Variability of cardiopulmonary exercise testing in patients with atrial fibrillation and determination of exercise responders to high-intensity interval training and moderate-to-vigorous intensity continuous training. Applied Physiology, Nutrition, and Metabolism, https://doi.org/10.1139/apnm-2024-0060

Disabling atrial fibrillation (AF)-related symptoms and different testing settings may influence day-to-day cardiopulmonary exercise testing (CPET) measurements, which can affect exercise prescription for high-intensity interval training (HIIT) and m... Read More about Variability of cardiopulmonary exercise testing in patients with atrial fibrillation and determination of exercise responders to high-intensity interval training and moderate-to-vigorous intensity continuous training.