Outputs (214)

Cetuximab-conjugated chitosan-pectinate (modified) composite nanoparticles for targeting colon cancer (2019)
Journal Article
Sabra, R., Billa, N., & Roberts, C. J. (2019). Cetuximab-conjugated chitosan-pectinate (modified) composite nanoparticles for targeting colon cancer. International Journal of Pharmaceutics, 572, Article 118775. https://doi.org/10.1016/j.ijpharm.2019.118775

© 2019 Elsevier B.V. In the present study, we successfully developed a cetuximab-conjugated modified citrus pectin-chitosan nanoparticles for targeted delivery of curcumin (Cet-MCPCNPs) for the treatment of colorectal cancer. In vitro analyses reveal... Read More about Cetuximab-conjugated chitosan-pectinate (modified) composite nanoparticles for targeting colon cancer.

Extinction risk and conservation gaps for Aloe (Asphodelaceae) in the Horn of Africa (2019)
Journal Article
Bachman, S. P., Wilkin, P., Reader, T., Field, R., Weber, O., Nordal, I., & Demissew, S. (2020). Extinction risk and conservation gaps for Aloe (Asphodelaceae) in the Horn of Africa. Biodiversity and Conservation, 29(1), 77–98. https://doi.org/10.1007/s10531-019-01870-0

Identification of conservation priorities is essential for conservation planning, especially as the biodiversity crisis develops. We aimed to support conservation prioritisation by addressing knowledge gaps for the genus Aloe in the Horn of Africa. S... Read More about Extinction risk and conservation gaps for Aloe (Asphodelaceae) in the Horn of Africa.

Selection-based model of prokaryote pangenomes (2019)
Other
Domingo-Sananes, M. R., & McInerney, J. O. (2019). Selection-based model of prokaryote pangenomes

Chronic effects of high-intensity interval training on postprandial lipemia in healthy men (2019)
Journal Article
Wilhelmsen, A. J., Tsintzas, K., Mallinson, J., Jones, R., Cooper, S., & Taylor, T. (2019). Chronic effects of high-intensity interval training on postprandial lipemia in healthy men. Journal of Applied Physiology, 127(6), 1763-1771. https://doi.org/10.1152/japplphysiol.00131.2019

The aim of this study was to determine thechronic (≥72h post-exercise) effects of high intensity interval training (HIIT) on postprandial lipaemia and metabolic markers in healthy volunteers. Eight physically active young males (Mean ± SD: age 22 ± 3... Read More about Chronic effects of high-intensity interval training on postprandial lipemia in healthy men.

Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection (2019)
Journal Article
Kulcsar, K. A., Coleman, C. M., Beck, S. E., & Frieman, M. B. (2019). Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection. JCI insight, 4(20), 1-18. https://doi.org/10.1172/jci.insight.131774

Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 in Saudi Arabia and has caused over 2400 cases and more than 800 deaths. Epidemiological studies identified diabetes as the primary comorbidity associated with severe or lethal M... Read More about Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection.

Comparative Docking to Distinct G Protein–Coupled Receptor Conformations Exclusively Yields Ligands with Agonist Efficacy (2019)
Journal Article
Scharf, M. M., Bünemann, M., Baker, J. G., & Kolb, P. (2019). Comparative Docking to Distinct G Protein–Coupled Receptor Conformations Exclusively Yields Ligands with Agonist Efficacy. Molecular Pharmacology, 96(6), 851-861. https://doi.org/10.1124/mol.119.117515

G protein-coupled receptors exist in a whole spectrum of conformations which are stabilised by the binding of ligands with different efficacy or intracellular effector proteins. Here, we investigate whether three-dimensional structures of receptor co... Read More about Comparative Docking to Distinct G Protein–Coupled Receptor Conformations Exclusively Yields Ligands with Agonist Efficacy.

A randomized, controlled, double-blind crossover study on the effects of isoeffective and isovolumetric intravenous crystalloid and gelatin on blood volume, and renal and cardiac hemodynamics (2019)
Journal Article
Bradley, C. R., Bragg, D. D., Cox, E. F., El-Sharkawy, A. M., Buchanan, C. E., Chowdhury, A. H., …Lobo, D. N. (2020). A randomized, controlled, double-blind crossover study on the effects of isoeffective and isovolumetric intravenous crystalloid and gelatin on blood volume, and renal and cardiac hemodynamics. Clinical Nutrition, 39(7), 2070-2079. https://doi.org/10.1016/j.clnu.2019.09.011

Background & aims Blood volume expanding properties of colloids are superior to crystalloids. In addition to oncotic/osmotic properties, the electrolyte composition of infusions may have important effects on visceral perfusion, with infusions contai... Read More about A randomized, controlled, double-blind crossover study on the effects of isoeffective and isovolumetric intravenous crystalloid and gelatin on blood volume, and renal and cardiac hemodynamics.

Author response: Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex (2019)
Other
Qu, Y., Hahn, I., Lees, M., Parkin, J., Voelzmann, A., Dorey, K., …Prokop, A. (2019). Author response: Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex

Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model (2019)
Journal Article
Costa-Marques, L., Arnold, K., Pardon, M. C., Leovsky, C., Swarbrick, S., Fabian, C., & Stolzing, A. (2019). Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model. Translational Neurodegeneration, 8, Article 33. https://doi.org/10.1186/s40035-019-0173-9

© 2019 The Author(s). Background: We investigated early hallmarks of putative therapeutic effects following systemic transplantation of bone marrow derived macrophages (BM-M) in APP/PS1 transgenic mice. Method: BM-M were transplanted into the tail ve... Read More about Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model.

Computer Tomography-Based Psoas Skeletal Muscle Area and Radiodensity are Poor Sentinels for Whole L3 Skeletal Muscle Values (2019)
Journal Article
Rollins, K. E., Gopinath, A., Awwad, A., Macdonald, I. A., & Lobo, D. N. (2020). Computer Tomography-Based Psoas Skeletal Muscle Area and Radiodensity are Poor Sentinels for Whole L3 Skeletal Muscle Values. Clinical Nutrition, 39(7), 2227-2232. https://doi.org/10.1016/j.clnu.2019.10.003

Background and aims Computed tomography (CT)-based measurement of skeletal muscle cross-sectional area (CSA) and Hounsfield unit (HU) radiodensity are used to assess the presence of sarcopenia and myosteatosis, respectively. The validated CT-based t... Read More about Computer Tomography-Based Psoas Skeletal Muscle Area and Radiodensity are Poor Sentinels for Whole L3 Skeletal Muscle Values.