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MAARTEN TAAL's Outputs (66)

The Impact of Primary Renal Diagnosis on Prognosis and the Varying Predictive Power of Albuminuria in the NURTuRE-CKD Study (2024)
Journal Article
McDonnell, T., Kalra, P. A., Vuilleumier, N., Cockwell, P., Wheeler, D. C., Fraser, S. D., Banks, R. E., & Taal, M. W. (2024). The Impact of Primary Renal Diagnosis on Prognosis and the Varying Predictive Power of Albuminuria in the NURTuRE-CKD Study. American Journal of Nephrology, 1-12. https://doi.org/10.1159/000541770

Introduction: The definition of CKD is broad, which neglects the heterogeneity of risk across primary renal diseases.

Methods: The National Unified Renal Translational Research Enterprise (NURTuRE)-CKD is an ongoing UK, prospective multicenter coh... Read More about The Impact of Primary Renal Diagnosis on Prognosis and the Varying Predictive Power of Albuminuria in the NURTuRE-CKD Study.

Kidney Beam - a cost-effective digital intervention to improve mental health (2024)
Journal Article
Greenwood, S. A., Briggs, J., Walklin, C., Mangahis, E., Young, H. M., Castle, E. M., Billany, R. E., Asgari, E., Bhandari, S., Bishop, N., Bramham, K., Burton, J. O., Campbell, J., Chilcot, J., Cooper, N., Deelchand, V., Graham-Brown, M. P., Haggis, L., Hamilton, A., Jesky, M., …Macdonald, J. (2024). Kidney Beam - a cost-effective digital intervention to improve mental health. Kidney International Reports, 9(11), 3204-3217. https://doi.org/10.1016/j.ekir.2024.08.030

Introduction: There is inequity in the provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health... Read More about Kidney Beam - a cost-effective digital intervention to improve mental health.

Optimizing kidney and cardiovascular protection in an era of multiple effective treatments (2024)
Journal Article
Taal, M. W. (2024). Optimizing kidney and cardiovascular protection in an era of multiple effective treatments. Current Opinion in Nephrology and Hypertension, 33(6), 551-556. https://doi.org/10.1097/MNH.0000000000001019

Purpose of review After decades of relying on the control of hypertension and treatment with renin angiotensin system inhibitors as the only evidence-based interventions to slow the progression of chronic kidney disease (CKD), we have entered an era... Read More about Optimizing kidney and cardiovascular protection in an era of multiple effective treatments.

Accuracy of glomerular filtration rate estimation using creatinine and cystatin C for identifying and monitoring moderate chronic kidney disease: the eGFR-C study. (2024)
Journal Article
Lamb, E. J., Barratt, J., Brettell, E. A., Cockwell, P., Dalton, R. N., Deeks, J. J., Eaglestone, G., Pellatt-Higgins, T., Kalra, P. A., Khunti, K., Loud, F. C., Ottridge, R. S., Potter, A., Rowe, C., Scandrett, K., Sitch, A. J., Stevens, P. E., Sharpe, C. C., Shinkins, B., Smith, A., …Taal, M. W. (2024). Accuracy of glomerular filtration rate estimation using creatinine and cystatin C for identifying and monitoring moderate chronic kidney disease: the eGFR-C study. Health Technology Assessment, 28(35), 1-169. https://doi.org/10.3310/HYHN1078

Background: Estimation of glomerular filtration rate using equations based on creatinine is widely used to manage chronic kidney disease. In the UK, the Chronic Kidney Disease Epidemiology Collaboration creatinine equation is recommended. Other publi... Read More about Accuracy of glomerular filtration rate estimation using creatinine and cystatin C for identifying and monitoring moderate chronic kidney disease: the eGFR-C study..

Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies (2024)
Journal Article
Abhishek, A., Stevenson, M. D., Nakafero, G., Grainge, M. J., Evans, I., Alabas, O., Card, T., Taal, M. W., Aithal, G. P., Fox, C. P., Mallen, C. D., van der Windt, D. A., Riley, R. D., Warren, R. B., & Williams, H. C. (2024). Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies. British Journal of Dermatology, 190(4), 559-564. https://doi.org/10.1093/bjd/ljad430

Background: There is no evidence base to support the use of 6-monthly monitoring blood tests for the early detection of liver, blood and renal toxicity during established anti-tumour necrosis factor alpha (TNFα) treatment. Objectives: To evaluate the... Read More about Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies.

National Unified Renal Translational Research Enterprise: Idiopathic Nephrotic Syndrome (NURTuRE-INS) study (2024)
Journal Article
Colby, E., Hayward, S., Benavente, M., Robertson, F., Bierzynska, A., Osborne, A., Parmesar, K., Afzal, M., Chapman, T., Ullah, F., Davies, E., Nation, M., Cook, W., Johnson, T., Andag, U., Radresa, O., Skroblin, P., Bayerlova, M., Unwin, R., Vuilleumier, N., …Saleem, M. A. (2024). National Unified Renal Translational Research Enterprise: Idiopathic Nephrotic Syndrome (NURTuRE-INS) study. Clinical Kidney Journal, 17(8), Article sfae096. https://doi.org/10.1093/ckj/sfae096

Background
Idiopathic Nephrotic Syndrome (INS) is a heterogenous disease and current classification is based on observational responses to therapies or kidney histology. The National Unified Renal Translational Research Enterprise (NURTuRE)-INS coho... Read More about National Unified Renal Translational Research Enterprise: Idiopathic Nephrotic Syndrome (NURTuRE-INS) study.

Prospective study of change in skin autofluorescence over time and mortality in people receiving hemodialysis (2024)
Journal Article
Viramontes-Hörner, D., Selby, N. M., & Taal, M. W. (2024). Prospective study of change in skin autofluorescence over time and mortality in people receiving hemodialysis. Kidney International Reports, 9(7), 2110-2116. https://doi.org/10.1016/j.ekir.2024.03.020

Introduction: Elevated skin autofluorescence (SAF), a measure of tissue accumulation of advanced glycation end products (AGEs), is a strong predictor of all-cause and cardiovascular mortality in the hemodialysis population. However, prospective studi... Read More about Prospective study of change in skin autofluorescence over time and mortality in people receiving hemodialysis.

Regional variation of COVID-19 admissions, acute kidney injury and mortality in England - a national observational study using administrative data (2024)
Journal Article
Kolhe, N. V., Fluck, R. J., & Taal, M. W. (in press). Regional variation of COVID-19 admissions, acute kidney injury and mortality in England - a national observational study using administrative data. BMC Infectious Diseases, 24(1), Article 346. https://doi.org/10.1186/s12879-024-09210-6

Background: This study explores regional variations in COVID-19 hospitalization rates, in-hospital mortality, and acute kidney injury (AKI) in England. We investigated the influence of population demographic characteristics, viral strain changes, and... Read More about Regional variation of COVID-19 admissions, acute kidney injury and mortality in England - a national observational study using administrative data.

Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases (2024)
Journal Article
Fuller, A., Hancox, J., Williams, H. C., Card, T., Taal, M. W., Aithal, G. P., Fox, C. P., Mallen, C. D., Maxwell, J. R., Bingham, S., Vedhara, K., & Abhishek, A. (in press). Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases. Rheumatology, Article keae175. https://doi.org/10.1093/rheumatology/keae175

Objective
To explore the acceptability of an individualised risk-stratified approach to monitoring for target-organ toxicity in adult patients with immune-mediated inflammatory diseases established on immune-suppressing treatment(s).

Methods
Adu... Read More about Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases.

Multivariate canonical correlation analysis identifies additional genetic variants for chronic kidney disease (2024)
Journal Article
Osborne, A. J., Bierzynska, A., Colby, E., Andag, U., Kalra, P. A., Radresa, O., …Campbell, C. (2024). Multivariate canonical correlation analysis identifies additional genetic variants for chronic kidney disease. npj Systems Biology and Applications, 10(1), Article 28. https://doi.org/10.1038/s41540-024-00350-8

Chronic kidney diseases (CKD) have genetic associations with kidney function. Univariate genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with estimated glomerular filtration rate (eGFR) and blo... Read More about Multivariate canonical correlation analysis identifies additional genetic variants for chronic kidney disease.

Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation (2024)
Journal Article
Abhishek, A., Grainge, M., Card, T., Williams, H. C., Taal, M. W., Aithal, G. P., …Riley, R. (2024). Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation. RMD Open, 10(1), Article e003980. https://doi.org/10.1136/rmdopen-2023-003980

Background Sulfasalazine-induced cytopenia, nephrotoxicity and hepatotoxicity is uncommon during long-term treatment. Some guidelines recommend 3 monthly monitoring blood tests indefinitely during long-term treatment while others recommend stopping m... Read More about Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation.

The development and internal pilot trial of a digital physical activity and emotional well-being intervention (Kidney BEAM) for people with chronic kidney disease (2024)
Journal Article
Young, H. M. L., Castle, E. M., Briggs, J., Walklin, C., Billany, R. E., Asgari, E., Bhandari, S., Bishop, N., Bramham, K., Burton, J. O., Campbell, J., Chilcot, J., Cooper, N., Deelchand, V., Graham-Brown, M. P. M., Haggis, L., Hamilton, A., Jesky, M., Kalra, P. A., Koufaki, P., …Greenwood, S. A. (2024). The development and internal pilot trial of a digital physical activity and emotional well-being intervention (Kidney BEAM) for people with chronic kidney disease. Scientific Reports, 14, Article 700. https://doi.org/10.1038/s41598-023-50507-4

This trial assessed the feasibility and acceptability of Kidney BEAM, a physical activity and emotional well-being self-management digital health intervention (DHI) for people with chronic kidney disease (CKD), which offers live and on-demand physica... Read More about The development and internal pilot trial of a digital physical activity and emotional well-being intervention (Kidney BEAM) for people with chronic kidney disease.

Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation (2023)
Preprint / Working Paper
Abhishek, A., Grainge, M. J., Card, T., Williams, H. C., Taal, M. W., Aithal, G. P., Fox, C. P., Mallen, C. D., Stevenson, M. D., Nakafero, G., & Riley, R. D. Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation

Background Sulfasalazine induced cytopenia, nephrotoxicity, and hepatotoxicity is uncommon during long-term treatment. Some guidelines recommend three monthly monitoring blood-tests indefinitely while others recommend stopping monitoring after one ye... Read More about Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation.

Multiparametric Renal Magnetic Resonance Imaging for Prediction and Annual Monitoring of the Progression of Chronic Kidney Disease over Two Years (2023)
Journal Article
Buchanan, C. E., Mahmoud, H., Cox, E. F., Prestwich, B. L., Noble, R. A., Selby, N. M., …Francis, S. T. (2023). Multiparametric Renal Magnetic Resonance Imaging for Prediction and Annual Monitoring of the Progression of Chronic Kidney Disease over Two Years. Journal of Clinical Medicine, 12(23), Article 7282. https://doi.org/10.3390/jcm12237282

Background: Multiparametric renal Magnetic Resonance Imaging (MRI) provides a non-invasive method to assess kidney structure and function, but longitudinal studies are limited. Methods: A total of 22 patients with CKD category G3-4 (estimated glomeru... Read More about Multiparametric Renal Magnetic Resonance Imaging for Prediction and Annual Monitoring of the Progression of Chronic Kidney Disease over Two Years.

Evaluating the effect of a digital health intervention to enhance physical activity in people with chronic kidney disease (Kidney BEAM): a multicentre, randomised controlled trial in the UK (2023)
Journal Article
Greenwood, S. A., Young, H. M., Briggs, J., Castle, E. M., Walklin, C., Haggis, L., …Macdonald, J. H. (2024). Evaluating the effect of a digital health intervention to enhance physical activity in people with chronic kidney disease (Kidney BEAM): a multicentre, randomised controlled trial in the UK. Lancet Digital Health, 6(1), E23-E32. https://doi.org/10.1016/S2589-7500%2823%2900204-2

Background: Remote digital health interventions to enhance physical activity provide a potential solution to improve the sedentary behaviour, physical inactivity, and poor health-related quality of life that are typical of chronic conditions, particu... Read More about Evaluating the effect of a digital health intervention to enhance physical activity in people with chronic kidney disease (Kidney BEAM): a multicentre, randomised controlled trial in the UK.

Blood Pressure targets in Chronic Kidney Disease: still no consensus (2023)
Journal Article
Lucas, B., & Taal, M. W. (2023). Blood Pressure targets in Chronic Kidney Disease: still no consensus. Current Opinion in Nephrology and Hypertension, 32(6), 497-501. https://doi.org/10.1097/MNH.0000000000000920

Purpose of review
Despite a strong consensus that treatment of hypertension is fundamental to strategies seeking to slow chronic kidney disease (CKD) progression and reduce the associated risk of cardiovascular events (CVE), controversy persists re... Read More about Blood Pressure targets in Chronic Kidney Disease: still no consensus.

Risk-stratified monitoring for thiopurine toxicity in immune-mediated inflammatory diseases: prognostic model development, validation, and, health economic evaluation (2023)
Journal Article
Nakafero, G., Card, T., Grainge, M. J., Williams, H. C., Taal, M. W., Aithal, G. P., …Abhishek, A. (2023). Risk-stratified monitoring for thiopurine toxicity in immune-mediated inflammatory diseases: prognostic model development, validation, and, health economic evaluation. eClinicalMedicine, 64, Article 102213. https://doi.org/10.1016/j.eclinm.2023.102213

Background: Patients established on thiopurines (e.g., azathioprine) are recommended to undergo three-monthly blood tests for the early detection of blood, liver, or kidney toxicity. These side-effects are uncommon during long-term treatment. We deve... Read More about Risk-stratified monitoring for thiopurine toxicity in immune-mediated inflammatory diseases: prognostic model development, validation, and, health economic evaluation.

Randomised trial comparing standard versus thermocontrolled haemodialysis using intradialytic cardiac, brain and renal magnetic resonance imaging (2023)
Journal Article
Gullapudi, V. R. L., Cox, E. F., Buchanan, C. E., Canaud, B., White, K., Taal, M. W., …Francis, S. T. (2024). Randomised trial comparing standard versus thermocontrolled haemodialysis using intradialytic cardiac, brain and renal magnetic resonance imaging. Nephrology Dialysis Transplantation, 39(2), 233–241. https://doi.org/10.1093/ndt/gfad150

Background
Ischaemic end-organ damage during haemodialysis (HD) is a significant problem that may be ameliorated by intradialytic cooling. A randomised trial was performed to compare standard HD (SHD; dialysate temperature 37°C) and programmed cooli... Read More about Randomised trial comparing standard versus thermocontrolled haemodialysis using intradialytic cardiac, brain and renal magnetic resonance imaging.

Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK (2023)
Journal Article
Nakafero, G., Grainge, M. J., Williams, H. C., Card, T., Taal, M. W., Aithal, G. P., …Abhishek, A. (2023). Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK. BMJ, 381, Article e074678. https://doi.org/10.1136/bmj-2022-074678

OBJECTIVE: To develop and validate a prognostic model to inform risk stratified decisions on frequency of monitoring blood tests during long term methotrexate treatment. DESIGN: Retrospective cohort study. SETTING: Electronic health records within th... Read More about Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK.

Associations with age and glomerular filtration rate in a referred population with chronic kidney disease: Methods and baseline data from a UK multicentre cohort study (NURTuRE-CKD) (2023)
Journal Article
Taal, M. W., Lucas, B., Roderick, P., Cockwell, P., Wheeler, D. C., Saleem, M. A., …Kalra, P. A. (2023). Associations with age and glomerular filtration rate in a referred population with chronic kidney disease: Methods and baseline data from a UK multicentre cohort study (NURTuRE-CKD). Nephrology Dialysis Transplantation, 38(11), 2617–2626. https://doi.org/10.1093/ndt/gfad110

Background
Chronic kidney disease (CKD) is common but heterogenous and is associated with multiple adverse outcomes. The National Unified Renal Translational Research Enterprise (NURTuRE)-CKD cohort was established to investigate risk factors for cl... Read More about Associations with age and glomerular filtration rate in a referred population with chronic kidney disease: Methods and baseline data from a UK multicentre cohort study (NURTuRE-CKD).

Magnetic Resonance Imaging to Evaluate Kidney Structure, Function, and Pathology: Moving Toward Clinical Application (2023)
Journal Article
Francis, S. T., Selby, N. M., & Taal, M. W. (2023). Magnetic Resonance Imaging to Evaluate Kidney Structure, Function, and Pathology: Moving Toward Clinical Application. American Journal of Kidney Diseases, 82(4), 491-504. https://doi.org/10.1053/j.ajkd.2023.02.007

Recent advances in multiparametric magnetic resonance imaging (MRI) allow multiple quantitative measures to assess kidney morphology, tissue microstructure, oxygenation, kidney blood flow, and perfusion to be collected in a single scan session. Anima... Read More about Magnetic Resonance Imaging to Evaluate Kidney Structure, Function, and Pathology: Moving Toward Clinical Application.

Potential clinical value of catheters impregnated with antimicrobials for the prevention of infections associated with peritoneal dialysis (2023)
Journal Article
Taal, M. W., Dukka, H., & Bayston, R. (2023). Potential clinical value of catheters impregnated with antimicrobials for the prevention of infections associated with peritoneal dialysis. Expert Review of Medical Devices, 20(6), 459-466. https://doi.org/10.1080/17434440.2023.2205587

Introduction
Peritoneal dialysis (PD) is a widely used dialysis modality, which offers the advantage of being a home therapy but is associated with a risk of potentially serious infections, including exit site infection, catheter tunnel infection, a... Read More about Potential clinical value of catheters impregnated with antimicrobials for the prevention of infections associated with peritoneal dialysis.

Quality of life in older adults with chronic kidney disease and transient changes in renal function: Findings from the Oxford Renal cohort (2022)
Journal Article
Busa, I., Ordóñez-Mena, J. M., Yang, Y., Wolstenholme, J., Petrou, S., Taylor, C. J., … Hobbs, F. R. (2022). Quality of life in older adults with chronic kidney disease and transient changes in renal function: Findings from the Oxford Renal cohort. PLoS ONE, 17(10), Article e0275572. https://doi.org/10.1371/journal.pone.0275572

BACKGROUND: Quality of life (QoL) is an important measure of disease burden and general health perception. The relationship between early chronic kidney disease (CKD) and QoL remains poorly understood. The Oxford Renal Study (OxRen) cohort comprises... Read More about Quality of life in older adults with chronic kidney disease and transient changes in renal function: Findings from the Oxford Renal cohort.

Room for improvement: diagnosing and managing acute coronary syndromes in persons with reduced eGFR (2022)
Journal Article
Horne, K. L., Taal, M. W., & Selby, N. M. (2022). Room for improvement: diagnosing and managing acute coronary syndromes in persons with reduced eGFR. Kidney International, 102(1), 20-22. https://doi.org/10.1016/j.kint.2022.04.017

Cardiovascular events are the leading cause of death in chronic kidney disease. A recent analysis from the High-Sensitivity Troponin in the Evaluation of Patients With Suspected Acute Coronary Syndrome trial focused on results in those with reduced e... Read More about Room for improvement: diagnosing and managing acute coronary syndromes in persons with reduced eGFR.

Defining improvement in chronic kidney disease: regression and remission (2022)
Journal Article
Taal, M. W. (2022). Defining improvement in chronic kidney disease: regression and remission. Current Opinion in Nephrology and Hypertension, 31(6), 517-521. https://doi.org/10.1097/MNH.0000000000000830

Purpose of review: International definitions exist for chronic kidney disease (CKD) progression and kidney failure but despite evidence that kidney function may improve, there are no agreed definitions for regression and remission of CKD. In the ligh... Read More about Defining improvement in chronic kidney disease: regression and remission.

Simple, high-throughput measurement of gut-derived short-chain fatty acids in clinically relevant biofluids using gas chromatography-mass spectrometry (2022)
Journal Article
Bain, J. T., Taal, M. W., Selby, N. M., Reynolds, J. C., & Heaney, L. M. (2022). Simple, high-throughput measurement of gut-derived short-chain fatty acids in clinically relevant biofluids using gas chromatography-mass spectrometry. Journal of Mass Spectrometry & Advances in the Clinical Lab, 25, 36-43. https://doi.org/10.1016/j.jmsacl.2022.07.002

Introduction

The quantitative measurement of circulating gut bacteria-derived metabolites has increased in recent years due to their associations with health and disease. While much of the previous attention has been placed on metabolites consider... Read More about Simple, high-throughput measurement of gut-derived short-chain fatty acids in clinically relevant biofluids using gas chromatography-mass spectrometry.

Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum (2021)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Taal, M. W., Aithal, G. P., Zhang, W., …Abhishek, A. (2022). Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum. Rheumatology, 61(7), 2783-2791. https://doi.org/10.1093/rheumatology/keab790

OBJECTIVE: To develop and validate a prognostic model for LEF discontinuation with abnormal blood test results. METHODS: Data from the Clinical Practice Research Datalink Gold and Aurum were used for model development and external validation, respect... Read More about Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum.

Impact of malnutrition on health-related quality of life in persons receiving dialysis: a prospective study (2021)
Journal Article
Viramontes-Hörner, D., Pittman, Z., Selby, N. M., & Taal, M. W. (2022). Impact of malnutrition on health-related quality of life in persons receiving dialysis: a prospective study. British Journal of Nutrition, 127(11), 1647-1655. https://doi.org/10.1017/S000711452100249X

Health-related quality of life (HRQoL) is severely impaired in persons receiving dialysis. Malnutrition has been associated with some measures of poor HRQoL in cross-sectional analyses in dialysis populations, but no studies have assessed the impact... Read More about Impact of malnutrition on health-related quality of life in persons receiving dialysis: a prospective study.

Multiparametric MRI assessment of renal structure and function in acute kidney injury and renal recovery (2021)
Journal Article
Buchanan, C., Mahmoud, H., Cox, E., Noble, R., Prestwich, B., Kasmi, I., …Selby, N. M. (2021). Multiparametric MRI assessment of renal structure and function in acute kidney injury and renal recovery. Clinical Kidney Journal, 14(8), 1969-1976. https://doi.org/10.1093/ckj/sfaa221

Background: Acute Kidney Injury (AKI) is associated with a marked increase in mortality as well as subsequent chronic kidney disease (CKD) and end stage kidney disease. We performed multiparametric MRI with the aim of identifying potential non-invasi... Read More about Multiparametric MRI assessment of renal structure and function in acute kidney injury and renal recovery.

Patients' and kidney care team's perspectives of treatment burden and capacity in older people with chronic kidney disease: A qualitative study (2020)
Journal Article
Hounkpatin, H. O., Leydon, G. M., Veighey, K., Armstrong, K., Santer, M., Taal, M. W., …Fraser, S. D. (2020). Patients' and kidney care team's perspectives of treatment burden and capacity in older people with chronic kidney disease: A qualitative study. BMJ Open, 10(12), Article e042548. https://doi.org/10.1136/bmjopen-2020-042548

Objective Chronic kidney disease (CKD) is often a multimorbid condition and progression to more severe disease is commonly associated with increased management requirements, including lifestyle change, more medication and greater clinician involvemen... Read More about Patients' and kidney care team's perspectives of treatment burden and capacity in older people with chronic kidney disease: A qualitative study.

Iterative Run-to-Run Learning Model to Derive Continuous Brachial Pressure Estimates from Arterial and Venous Lines During Dialysis Treatment (2020)
Journal Article
Stewart, J., Stewart, P., Walker, T., Viramontes Horner, D., Lucas, B., White, K., …Morris, M. (2021). Iterative Run-to-Run Learning Model to Derive Continuous Brachial Pressure Estimates from Arterial and Venous Lines During Dialysis Treatment. Biomedical Signal Processing and Control, 65, Article 102346. https://doi.org/10.1016/j.bspc.2020.102346

Objective: Non-invasive continuous blood pressure monitoring is not yet part of routine practice in renal dialysis units but could be a valuable tool in the detection and prevention of significant variations in patient blood pressure during treatment... Read More about Iterative Run-to-Run Learning Model to Derive Continuous Brachial Pressure Estimates from Arterial and Venous Lines During Dialysis Treatment.

A Feasibility Study of Non-Invasive Continuous Estimation of Brachial Pressure Derived from Arterial and Venous Lines During Dialysis (2020)
Journal Article
Stewart, J., Stewart, P., Walker, T., Horner, D. V., Lucas, B., White, K., …Taal, M. W. (2021). A Feasibility Study of Non-Invasive Continuous Estimation of Brachial Pressure Derived from Arterial and Venous Lines During Dialysis. IEEE Journal of Translational Engineering in Health and Medicine, 9, 1-1. https://doi.org/10.1109/JTEHM.2020.3035988

Objective: Intradialytic haemodynamic instability is a significant clinical problem, leading to end-organ ischaemia and contributing to morbidity and mortality in haemodialysis patients. Non-invasive continuous blood pressure monitoring is not curren... Read More about A Feasibility Study of Non-Invasive Continuous Estimation of Brachial Pressure Derived from Arterial and Venous Lines During Dialysis.

Acute kidney injury associated with COVID-19: A retrospective cohort study (2020)
Journal Article
Kolhe, N. V., Fluck, R. J., Selby, N. M., & Taal, M. W. (2020). Acute kidney injury associated with COVID-19: A retrospective cohort study. PLoS Medicine, 17(10), Article e1003406. https://doi.org/10.1371/journal.pmed.1003406

Background Initial reports indicate a high incidence of acute kidney injury (AKI) in Coronavirus Disease 2019 (COVID-19), but more data are required to clarify if COVID-19 is an independent risk factor for AKI and how COVID-19–associated AKI may diff... Read More about Acute kidney injury associated with COVID-19: A retrospective cohort study.

Symptom-burden in people living with frailty and chronic kidney disease (2020)
Journal Article
Nixon, A. C., Wilkinson, T. J., Young, H. M. L., Taal, M. W., Pendleton, N., Mitra, S., …Smith, A. C. (2020). Symptom-burden in people living with frailty and chronic kidney disease. BMC Nephrology, 21, Article 411. https://doi.org/10.1186/s12882-020-02063-6

Background: Frailty is independently associated with worse health-related quality of life (HRQOL) in chronic kidney disease (CKD). However, the relationship between frailty and symptom experience is not well described in people living with CKD. This... Read More about Symptom-burden in people living with frailty and chronic kidney disease.

The PrEscription of intraDialytic exercise to improve quAlity of Life in patients with chronic kidney disease trial: study design and baseline data for a multicentre randomized controlled trial (2020)
Journal Article
Greenwood, S. A., Koufaki, P., Macdonald, J., Bhandari, S., Burton, J., Dasgupta, I., …Mercer, T. H. (2021). The PrEscription of intraDialytic exercise to improve quAlity of Life in patients with chronic kidney disease trial: study design and baseline data for a multicentre randomized controlled trial. Clinical Kidney Journal, 14(5), 1345–1355. https://doi.org/10.1093/ckj/sfaa107

Background
Exercise interventions designed to improve physical function and reduce sedentary behaviour in haemodialysis (HD) patients might improve exercise capacity, reduce fatigue and lead to improved quality of life (QOL). The PrEscription of int... Read More about The PrEscription of intraDialytic exercise to improve quAlity of Life in patients with chronic kidney disease trial: study design and baseline data for a multicentre randomized controlled trial.

Nutritional status assessment: a neglected biomarker in persons with end- stage kidney disease (2020)
Journal Article
Viramontes-Hörner, D., & Taal, M. W. (2020). Nutritional status assessment: a neglected biomarker in persons with end- stage kidney disease. Current Opinion in Nephrology and Hypertension, 29(6), 547-554. https://doi.org/10.1097/MNH.0000000000000651

Purpose of review: Malnutrition is a frequent complication and risk factor for adverse outcomes in the dialysis population that is often underrecognized and neglected. This article reviews published literature on the associations between malnutrition... Read More about Nutritional status assessment: a neglected biomarker in persons with end- stage kidney disease.

Prevalence of chronic kidney disease in adults in England: comparison of nationally representative cross-sectional surveys from 2003 to 2016 (2020)
Journal Article
Hounkpatin, H. O., Harris, S., Fraser, S. D., Day, J., Mindell, J. S., Taal, M. W., …Roderick, P. J. (2020). Prevalence of chronic kidney disease in adults in England: comparison of nationally representative cross-sectional surveys from 2003 to 2016. BMJ Open, 10(8), Article e038423. https://doi.org/10.1136/bmjopen-2020-038423

Objectives: To identify recent trends in chronic kidney disease (CKD) prevalence in England and explore their association with changes in sociodemographic, behavioural and clinical factors.
Design: Pooled cross-sectional analysis.
Setting: Health... Read More about Prevalence of chronic kidney disease in adults in England: comparison of nationally representative cross-sectional surveys from 2003 to 2016.

Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study (2020)
Journal Article
Fraser, S. D., Barker, J., Roderick, P. J., Yuen, H. M., Shardlow, A., Morris, J. E., …Taal, M. W. (2020). Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study. BMJ Open, 10, Article e040286. https://doi.org/10.1136/bmjopen-2020-040286

Objectives: To determine the associations between comorbidities, health-related quality of life (HRQoL) and functional impairment in people with mild-to-moderate chronic kidney disease (CKD) in primary care.

Design: Cross-sectional analysis at 5-y... Read More about Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study.

Helping people to live well with chronic kidney disease (2020)
Journal Article
Fraser, S., & Taal, M. (2020). Helping people to live well with chronic kidney disease. British Journal of Hospital Medicine, 81(6), https://doi.org/10.12968/hmed.2020.0069

Reduced glomerular filtration rate and presence of albuminuria are both associated with increased risk of several poor outcomes. People with chronic kidney disease also commonly suffer from lower quality of life than their age-matched peers. The expe... Read More about Helping people to live well with chronic kidney disease.

Skin autofluorescence and malnutrition as predictors of mortality in persons receiving dialysis: a prospective cohort study (2020)
Journal Article
Viramontes Hörner, D., Selby, N. M., & Taal, M. W. (2020). Skin autofluorescence and malnutrition as predictors of mortality in persons receiving dialysis: a prospective cohort study. Journal of Human Nutrition and Dietetics, 33(6), 852-861. https://doi.org/10.1111/jhn.12764

Background

Skin autofluorescence (SAF), which is a measure of accumulation of advanced glycation end‐products (AGE), and malnutrition are each associated with higher mortality in dialysis populations, although no studies have investigated these po... Read More about Skin autofluorescence and malnutrition as predictors of mortality in persons receiving dialysis: a prospective cohort study.

Factors associated with change in skin autofluorescence in persons receiving dialysis (2020)
Journal Article
Viramontes Hörner, D., Selby, N. M., & Taal, M. W. (2020). Factors associated with change in skin autofluorescence in persons receiving dialysis. Kidney International Reports, 5(5), 654-662. https://doi.org/10.1016/j.ekir.2020.02.003

Introduction

An increase over time in skin autofluorescence (SAF), a measure of accumulation of advanced glycation end products (AGE), predicts higher mortality on hemodialysis (HD). However, evidence is lacking regarding factors that contribute t... Read More about Factors associated with change in skin autofluorescence in persons receiving dialysis.

SGLT‐2 Inhibitor Renal Outcome Modification in Type‐2 Diabetes: Evidence from Studies in Patients with High or Low Renal Risk (2020)
Journal Article
Schernthaner, G., Groop, P.-H., Kalra, P. A., Ronco, C., & Taal, M. W. (2020). SGLT‐2 Inhibitor Renal Outcome Modification in Type‐2 Diabetes: Evidence from Studies in Patients with High or Low Renal Risk. Diabetes, Obesity and Metabolism, 22(7), 1024-1034. https://doi.org/10.1111/dom.13994

Data from three completed cardiovascular outcome trials (CVOTs), EMPA‐REG OUTCOME, CANVAS Program and DECLARE‐TIMI 58, add to the evidence supporting the potential renoprotective effects of sodium‐glucose linked transporter‐2 (SGLT2) inhibitors in pa... Read More about SGLT‐2 Inhibitor Renal Outcome Modification in Type‐2 Diabetes: Evidence from Studies in Patients with High or Low Renal Risk.

Impact of Dietetic Intervention on Skin Autofluorescence and Nutritional Status in Persons Receiving Dialysis: A Proof of Principle Study (2020)
Journal Article
Hörner, D. V., Willingham, F. C., Selby, N. M., & Taal, M. W. (2020). Impact of Dietetic Intervention on Skin Autofluorescence and Nutritional Status in Persons Receiving Dialysis: A Proof of Principle Study. Journal of Renal Nutrition, 30(6), 540-547. https://doi.org/10.1053/j.jrn.2019.12.006

Objective: Advanced glycation end-products (AGEs) are uremic toxins that result from oxidative stress and food consumption. We have previously reported that markers of malnutrition are more important determinants of increased skin autofluorescence (S... Read More about Impact of Dietetic Intervention on Skin Autofluorescence and Nutritional Status in Persons Receiving Dialysis: A Proof of Principle Study.

Biological Variation of Cardiac Troponins in Chronic Kidney Disease (2020)
Journal Article
Jones, R., Barrett, J., Brettell, E., Cockwell, P., Dalton, R. N., Deeks, J., …Lamb, E. J. (2020). Biological Variation of Cardiac Troponins in Chronic Kidney Disease. Annals of Clinical Biochemistry, 57(2), 162-169. https://doi.org/10.1177/0004563220906431

Background
Patients with chronic kidney disease often have increased plasma cardiac troponin concentration in the absence of myocardial infarction. Incidence of myocardial infarction is high in this population, and diagnosis, particularly of non ST-... Read More about Biological Variation of Cardiac Troponins in Chronic Kidney Disease.

A Paradigm to Discover Biomarkers Associated With Chronic Kidney Disease Progression (2020)
Journal Article
Ali, I., Ibrahim, S. T., Chinnadurai, R., Green, D., Taal, M., Whetton, T. D., & Kalra, P. A. (2020). A Paradigm to Discover Biomarkers Associated With Chronic Kidney Disease Progression. Biomarker Insights, 15, 117727192097614. https://doi.org/10.1177/1177271920976146

Biomarker discovery in the field of risk prediction in chronic kidney disease (CKD) embraces the prospect of improving our ability to risk stratify future adverse outcomes and thereby guide patient care in a new era of personalised medicine. However,... Read More about A Paradigm to Discover Biomarkers Associated With Chronic Kidney Disease Progression.

Coffee Consumption and Kidney Function: A Mendelian Randomization Study (2019)
Journal Article
Kennedy, O. J., Pirastu, N., Poole, R., Fallowfield, J. A., Hayes, P. C., Grzeszkowiak, E. J., …Roderick, P. J. (2019). Coffee Consumption and Kidney Function: A Mendelian Randomization Study. American Journal of Kidney Diseases, https://doi.org/10.1053/j.ajkd.2019.08.025

Rationale & Objective

Chronic kidney disease (CKD) is a leading cause of morbidity and mortality worldwide, with limited strategies for prevention and treatment. Coffee is a complex mixture of chemicals, and consumption has been associated with mo... Read More about Coffee Consumption and Kidney Function: A Mendelian Randomization Study.

Skin autofluorescence: an emerging biomarker in persons with kidney disease (2019)
Journal Article
Viramontes Horner, D., & Taal, M. W. (2019). Skin autofluorescence: an emerging biomarker in persons with kidney disease. Current Opinion in Nephrology and Hypertension, 28(6), 507–512. https://doi.org/10.1097/MNH.0000000000000549

Purpose of review: Skin autofluorescence (SAF) is a measure of the accumulation of advanced glycation end-products (AGEs) proposed to act as a marker of “cumulative metabolic stress”. This paper discusses mechanisms of AGE formation and reviews publi... Read More about Skin autofluorescence: an emerging biomarker in persons with kidney disease.

Chronic Kidney Disease: call for an age-adapted definition (2019)
Journal Article
Delanaye, P., Jager, K. J., Bökenkamp, A., Christensson, A., Dubourg, L., Eriksen, B. O., …van den Brand, J. A. (2019). Chronic Kidney Disease: call for an age-adapted definition. Journal of the American Society of Nephrology, 30(9), 1785-1805. https://doi.org/10.1681/ASN.2019030238

Current criteria for the diagnosis of chronic kidney disease (CKD) in adults include persistent signs of kidney damage; for example, increased urine albumin-to-creatinine ratio or a glomerular filtration rate (GFR) below the threshold of 60 mL/min pe... Read More about Chronic Kidney Disease: call for an age-adapted definition.

Considerable international variation exists in blood pressure control and antihypertensive prescription patterns in chronic kidney disease (2019)
Journal Article
Alencar de Pinho, N., Levin, A., Fukagawa, M., Hoy, W. E., Pecoits-Filho, R., Reichel, H., …Stengel, B. (2019). Considerable international variation exists in blood pressure control and antihypertensive prescription patterns in chronic kidney disease. Kidney International, 96(4), 983-994. https://doi.org/10.1016/j.kint.2019.04.032

Although blood pressure control is a major goal in chronic kidney disease, no worldwide overview of either its achievement or antihypertensive prescriptions is currently available. To evaluate this we compared crude prevalence of uncontrolled blood p... Read More about Considerable international variation exists in blood pressure control and antihypertensive prescription patterns in chronic kidney disease.

Quantitative assessment of renal structural and functional changes in chronic kidney disease using multi-parametric magnetic resonance imaging (2019)
Journal Article
Buchanan, C. E., Mahmoud, H., Cox, E. F., McCulloch, T., Prestwich, B. L., Taal, M. W., …Francis, S. T. (2020). Quantitative assessment of renal structural and functional changes in chronic kidney disease using multi-parametric magnetic resonance imaging. Nephrology Dialysis Transplantation, 35(6), 955-964. https://doi.org/10.1093/ndt/gfz129

BACKGROUND:
Multi-parametric magnetic resonance imaging (MRI) provides the potential for a more comprehensive non-invasive assessment of organ structure and function than individual MRI measures, but has not previously been comprehensively evaluated... Read More about Quantitative assessment of renal structural and functional changes in chronic kidney disease using multi-parametric magnetic resonance imaging.

Biological variation of measured and estimated glomerular filtration rate in patients with chronic kidney disease (2019)
Journal Article
Rowe, C., Sitch, A. J., Barratt, J., Brettell, E. A., Cockwell, P., Dalton, R. N., …Lamb, E. J. (2019). Biological variation of measured and estimated glomerular filtration rate in patients with chronic kidney disease. Kidney International, 96(2), 429-435. https://doi.org/10.1016/j.kint.2019.02.021

When assessing changes in glomerular filtration rate (GFR) it is important to differentiate pathological change from intrinsic biological and analytical variation. GFR is measured using complex reference methods (e.g., iohexol clearance). In clinical... Read More about Biological variation of measured and estimated glomerular filtration rate in patients with chronic kidney disease.

Effects of Sacubitril/Valsartan Versus Irbesartan in Patients With Chronic Kidney Disease: A Randomized Double-Blind Trial (2018)
Journal Article
Haynes, R., Judge, P. K., Staplin, N., Herrington, W. G., Storey, B. C., Bethel, A., …Baigent, C. (2018). Effects of Sacubitril/Valsartan Versus Irbesartan in Patients With Chronic Kidney Disease: A Randomized Double-Blind Trial. Circulation, 138(15), 1505-1514. https://doi.org/10.1161/CIRCULATIONAHA.118.034818

Background: Sacubitril/valsartan reduces the risk of cardiovascular mortality among patients with heart failure with reduced ejection fraction, but its effects on kidney function and cardiac biomarkers in people with moderate-to-severe chronic kidney... Read More about Effects of Sacubitril/Valsartan Versus Irbesartan in Patients With Chronic Kidney Disease: A Randomized Double-Blind Trial.

The association of nutritional factors and skin autofluorescence in persons receiving hemodialysis (2018)
Journal Article
Viramontes Hörner, D., Selby, N. M., & Taal, M. W. (2019). The association of nutritional factors and skin autofluorescence in persons receiving hemodialysis. Journal of Renal Nutrition, 29(2), 149-155. https://doi.org/10.1053/j.jrn.2018.07.004+hideArticle+Info

Objective: Advanced glycation end-products (AGEs) are uremic toxins that result from hyperglycemia, oxidative stress and systemic inflammation. AGEs are also formed in food during cooking. On the other hand, malnutrition may contribute to AGE formati... Read More about The association of nutritional factors and skin autofluorescence in persons receiving hemodialysis.

The clinical utility and cost impact of cystatin C measurement in the diagnosis and management of chronic kidney disease: A primary care cohort study (2017)
Journal Article
Shardlow, A., McIntyre, N. J., Fraser, S. D., Roderick, P., Raftery, J., Fluck, R. J., …Taal, M. W. (2017). The clinical utility and cost impact of cystatin C measurement in the diagnosis and management of chronic kidney disease: A primary care cohort study. PLoS Medicine, 14(10), Article e1002400. https://doi.org/10.1371/journal.pmed.1002400

© 2017 Shardlow et al. Background: To reduce over-diagnosis of chronic kidney disease (CKD) resulting from the inaccuracy of creatinine-based estimates of glomerular filtration rate (GFR), UK and international guidelines recommend that cystatin-C-bas... Read More about The clinical utility and cost impact of cystatin C measurement in the diagnosis and management of chronic kidney disease: A primary care cohort study.

Multiparametric renal magnetic resonance imaging: validation, interventions, and alterations in chronic kidney disease (2017)
Journal Article
Cox, E. F., Buchanan, C. E., Bradley, C. R., Prestwich, B., Mahmoud, H., Taal, M., Selby, N. M., & Francis, S. T. (2017). Multiparametric renal magnetic resonance imaging: validation, interventions, and alterations in chronic kidney disease. Frontiers in Physiology, 8, Article 696. https://doi.org/10.3389/fphys.2017.00696

Background: This paper outlines a multiparametric renal MRI acquisition and analysis protocol to allow non-invasive assessment of hemodynamics (renal artery blood flow and perfusion), oxygenation (BOLD T2*), and microstructure (diffusion, T1 mapping)... Read More about Multiparametric renal magnetic resonance imaging: validation, interventions, and alterations in chronic kidney disease.

Sodium MRI: a new frontier in imaging in nephrology (2017)
Journal Article
Francis, S. T., Buchanan, C., Prestwich, B., & Taal, M. W. (2017). Sodium MRI: a new frontier in imaging in nephrology. Current Opinion in Nephrology and Hypertension, 26(6), 435-441. https://doi.org/10.1097/MNH.0000000000000370

Purpose of review

This review focuses on the recent technological advances in quantitative sodium (23Na) MRI to provide a noninvasive measure of tissue viability for use in clinical studies of patients with kidney disease. 23Na MRI is the only non... Read More about Sodium MRI: a new frontier in imaging in nephrology.

Intradialytic Cardiac Magnetic Resonance Imaging to Assess Cardiovascular Responses in a Short-Term Trial of Hemodiafiltration and Hemodialysis (2016)
Journal Article
Buchanan, C., Mohammed, A., Cox, E., Köhler, K., Canaud, B., Taal, M. W., …McIntyre, C. W. (2017). Intradialytic Cardiac Magnetic Resonance Imaging to Assess Cardiovascular Responses in a Short-Term Trial of Hemodiafiltration and Hemodialysis. Journal of the American Society of Nephrology, 28(4), 1269-1277. https://doi.org/10.1681/ASN.2016060686

Hemodynamic stress during hemodialysis (HD) results in recurrent segmental ischemic injury (myocardial stunning) that drives cumulative cardiac damage. We performed a fully comprehensive study of the cardiovascular effect of dialysis sessions using i... Read More about Intradialytic Cardiac Magnetic Resonance Imaging to Assess Cardiovascular Responses in a Short-Term Trial of Hemodiafiltration and Hemodialysis.

Chronic kidney disease in primary care: outcomes after five years in a prospective cohort study (2016)
Journal Article
Shardlow, A., McIntyre, N. J., Fluck, R. J., McIntyre, C. W., & Taal, M. W. (2016). Chronic kidney disease in primary care: outcomes after five years in a prospective cohort study. PLoS Medicine, 13(9), 1-16. https://doi.org/10.1371/journal.pmed.1002128

Background

Chronic kidney disease (CKD) is commonly managed in primary care, but most guidelines have a secondary care perspective emphasizing the risk of end-stage kidney disease (ESKD) and need for renal replacement therapy. In this prospective... Read More about Chronic kidney disease in primary care: outcomes after five years in a prospective cohort study.

A simple care bundle for use in acute kidney injury: a propensity score-matched cohort study (2016)
Journal Article
Kolhe, N. V., Reilly, T., Leung, J., Fluck, R. J., Swinscoe, K. E., Selby, N. M., & Taal, M. W. (2016). A simple care bundle for use in acute kidney injury: a propensity score-matched cohort study. Nephrology Dialysis Transplantation, 31(11), https://doi.org/10.1093/ndt/gfw087

Background

Consensus guidelines for acute kidney injury (AKI) have recommended prompt treatment including attention to fluid balance, drug dosing and avoidance of nephrotoxins. These simple measures can be incorporated in a care bundle to facilita... Read More about A simple care bundle for use in acute kidney injury: a propensity score-matched cohort study.

Natural history of skeletal muscle mass changes in chronic kidney disease stage 4 and 5 patients: an observational study (2013)
Journal Article
John, S. G., Sigrist, M. K., Taal, M. W., & McIntyre, C. W. (2013). Natural history of skeletal muscle mass changes in chronic kidney disease stage 4 and 5 patients: an observational study. PLoS ONE, 8(5), Article e65372. https://doi.org/10.1371/journal.pone.0065372

Cross-sectional studies in dialysis demonstrate muscle wasting associated with loss of function, increased morbidity and mortality. The relative drivers are poorly understood. There is a paucity of data regarding interval change in muscle in pre-dial... Read More about Natural history of skeletal muscle mass changes in chronic kidney disease stage 4 and 5 patients: an observational study.

Hepatitis B and C infection in haemodialysis patients in Libya: prevalence, incidence and risk factors (2012)
Journal Article
Alashek, W. A., McIntyre, C. W., & Taal, M. W. (2012). Hepatitis B and C infection in haemodialysis patients in Libya: prevalence, incidence and risk factors. BMC Infectious Diseases, 12(235), https://doi.org/10.1186/1471-2334-12-265

Background: Patients receiving maintenance haemodialysis (HD) are at higher risk for acquiring Hepatitis B Virus
(HBV) and Hepatitis C Virus (HCV) infections than the general population. Strict infection control measures are
essential to prevent no... Read More about Hepatitis B and C infection in haemodialysis patients in Libya: prevalence, incidence and risk factors.