Associations with age and glomerular filtration rate in a referred population with chronic kidney disease: Methods and baseline data from a UK multicentre cohort study (NURTuRE-CKD)

Taal, Maarten W; Lucas, Bethany; Roderick, Paul; Cockwell, Paul; Wheeler, David C; Saleem, Moin A; Fraser, Simon D S; Banks, Rosamonde E; Johnson, Tim; Hale, Lorna J; Andag, Uwe; Skroblin, Philipp; Bayerlova, Michaela; Unwin, Robert; Vuilleumier, Nicolas; Dusaulcy, Rodolphe; Robertson, Fiona; Colby, Elizabeth; Pitcher, David; Braddon, Fiona; Benavente, Melissa; Davies, Elaine; Nation, Michael; Kalra, Philip A

Abstract

Background
Chronic kidney disease (CKD) is common but heterogenous and is associated with multiple adverse outcomes. The National Unified Renal Translational Research Enterprise (NURTuRE)-CKD cohort was established to investigate risk factors for clinically important outcomes in persons with CKD referred to secondary care.

Methods
Eligible participants with CKD stages G3-4 or stages G1-2 plus albuminuria > 30 mg/mmol were enrolled from 16 nephrology centres in England, Scotland and Wales from 2017 to 2019. Baseline assessment included demographic data, routine laboratory data and research samples. Clinical outcomes are being collected over 15 years by the UK Renal Registry using established data linkage. Baseline data are presented with subgroup analysis by age, sex and estimated GFR (eGFR).

Results
2996 participants were enrolled. Median (interquartile range) age was 66 (54 to 74) years, 58.5% were male, eGFR 33.8 (24.0 to 46.6) ml/min/1.73m2 and UACR 209 (33 to 926) mg/g. 1883 participants (69.1%) were in high-risk CKD categories. Primary renal diagnosis was CKD of unknown cause in 32.3%, glomerular disease in 23.4% and diabetic kidney disease in 11.5%. Older participants and those with lower eGFR had higher systolic blood pressure and were less likely to be treated with renin-angiotensin system inhibitors (RASi) but were more likely to receive a statin. Female participants were less likely to receive a RASi or statin.

Conclusions
NURTuRE-CKD is a prospective cohort of persons who are at relatively high risk of adverse outcomes. Long-term follow-up and a large biorepository create opportunities for research to improve risk prediction and investigate underlying mechanisms to inform new treatment development.

Citation

Taal, M. W., Lucas, B., Roderick, P., Cockwell, P., Wheeler, D. C., Saleem, M. A., Fraser, S. D. S., Banks, R. E., Johnson, T., Hale, L. J., Andag, U., Skroblin, P., Bayerlova, M., Unwin, R., Vuilleumier, N., Dusaulcy, R., Robertson, F., Colby, E., Pitcher, D., Braddon, F., …Kalra, P. A. (2023). Associations with age and glomerular filtration rate in a referred population with chronic kidney disease: Methods and baseline data from a UK multicentre cohort study (NURTuRE-CKD). Nephrology Dialysis Transplantation, 38(11), 2617–2626. https://doi.org/10.1093/ndt/gfad110

• Journal Article Type: Article
• Acceptance Date: Apr 24, 2023
• Online Publication Date: May 25, 2023
• Publication Date: 2023-11
• Deposit Date: May 4, 2023
• Publicly Available Date: Jun 20, 2023
• Journal: Nephrology Dialysis Transplantation
• Print ISSN: 0931-0509
• Electronic ISSN: 1460-2385
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 38
• Issue: 11
• Pages: 2617–2626
• DOI: https://doi.org/10.1093/ndt/gfad110
• Keywords: Albuminuria, chronic kidney disease, cohort study, risk profile
• Public URL: https://nottingham-repository.worktribe.com/output/20283527
• Publisher URL: https://academic.oup.com/ndt/advance-article/doi/10.1093/ndt/gfad110/7180015?login=false