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Highly sensitive optical fibre Bragg grating contact pressure sensor embedded in a polymer layer: modelling and experimental validation (2024)
Journal Article
Abeywardena, C., Zhang, Q., Korposh, S., Morgan, S., Bull, S., & Correia, R. (2024). Highly sensitive optical fibre Bragg grating contact pressure sensor embedded in a polymer layer: modelling and experimental validation. Results in Optics, 14, Article 100604. https://doi.org/10.1016/j.rio.2024.100604

This paper discusses mathematical modelling and experimental validation of a highly sensitive optical fibre Bragg grating (FBG) contact pressure sensor developed for healthcare applications. Bare FBGs are not very sensitive to pressure (~ 3x10-3 nm/M... Read More about Highly sensitive optical fibre Bragg grating contact pressure sensor embedded in a polymer layer: modelling and experimental validation.

Forehead monitoring of heart rate in neonatal intensive care (2023)
Journal Article
Stockwell, S. J., Kwok, T. C., Morgan, S. P., Sharkey, D., & Hayes-Gill, B. R. (2023). Forehead monitoring of heart rate in neonatal intensive care. Frontiers in Physiology, 14, Article 1127419. https://doi.org/10.3389/fphys.2023.1127419

Heart rate is an extremely important physiological parameter to measure in critically unwell infants, as it is the main physiological marker that changes in response to a change in infant condition. Heart rate is routinely measured peripherally on a... Read More about Forehead monitoring of heart rate in neonatal intensive care.

A quantitative laser speckle-based velocity prediction approach using machine learning (2023)
Journal Article
Hao, X., Wu, S., Lin, L., Chen, Y., Morgan, S. P., & Sun, S. (2023). A quantitative laser speckle-based velocity prediction approach using machine learning. Optics and Lasers in Engineering, 166, Article 107587. https://doi.org/10.1016/j.optlaseng.2023.107587

Laser speckle contrast imaging (LSCI) can be applied to non-invasive blood perfusion measurement with high resolution and fast speed. However, it is lack of measurement accuracy. The aim of this study is to enable quantitative measurement of LSCI by... Read More about A quantitative laser speckle-based velocity prediction approach using machine learning.

Long Period Grating Mach–Zehnder Interferometer Based Immunosensor with Temperature and Bulk Refractive Index Compensation (2022)
Journal Article
Wu, P., Liu, L., Morgan, S. P., Correia, R., & Korposh, S. (2022). Long Period Grating Mach–Zehnder Interferometer Based Immunosensor with Temperature and Bulk Refractive Index Compensation. Biosensors, 12(12), Article 1099. https://doi.org/10.3390/bios12121099

A long period grating Mach–Zehnder interferometer (LPGMZI) that consists of two identical long period gratings (LPGs) in a single fibre was developed to measure immunoglobulin M (IgM). The measured spectrum has fringes due to the interference between... Read More about Long Period Grating Mach–Zehnder Interferometer Based Immunosensor with Temperature and Bulk Refractive Index Compensation.

U-shape functionalized optical fibre sensors for measurement of anaesthetic propofol (2022)
Journal Article
Hernandez, F. U., Wang, T., Lee, S. W., Norris, A., Liu, L. L., Hayes-Gill, B. R., …Korposh, S. (2022). U-shape functionalized optical fibre sensors for measurement of anaesthetic propofol. Sensors and Actuators B: Chemical, 372, Article 132653. https://doi.org/10.1016/j.snb.2022.132653

Propofol is used widely for intravenous anaesthesia during surgery and sedation in critical care. There is no method currently to assay the concentration of propofol in plasma in real time. The ability to do so would significantly improve patient saf... Read More about U-shape functionalized optical fibre sensors for measurement of anaesthetic propofol.

Fibre Bragg Grating Based Interface Pressure Sensor for Compression Therapy (2022)
Journal Article
Bradbury, J. A., Zhang, Q., Hernandez Ledezma, F. U., Correia, R., Korposh, S., Hayes-Gill, B. R., …Morgan, S. P. (2022). Fibre Bragg Grating Based Interface Pressure Sensor for Compression Therapy. Sensors, 22(5), Article 1798. https://doi.org/10.3390/s22051798

Compression therapy is widely used as the gold standard for management of chronic venous insufficiency and venous leg ulcers, and the amount of pressure applied during the compression therapy is crucial in supporting healing. A fibre optic pressure s... Read More about Fibre Bragg Grating Based Interface Pressure Sensor for Compression Therapy.

Feasibility of a Novel ECG Electrode Placement Method in Newborn Infants (2022)
Journal Article
Henry, C., Shipley, L., Morgan, S., Crowe, J. A., Carpenter, J., Hayes-Gill, B., & Sharkey, D. (2022). Feasibility of a Novel ECG Electrode Placement Method in Newborn Infants. Neonatology, 119(2), 264-267. https://doi.org/10.1159/000521530

Background: International newborn resuscitation guidelines recommend electrocardiogram (ECG) heart rate (HR) monitoring at birth. We evaluated the application time of pre-set ECG electrodes fixed to a polyethene patch allowing adhesive-free attachmen... Read More about Feasibility of a Novel ECG Electrode Placement Method in Newborn Infants.

Intra-tracheal multiplexed sensing of contact pressure and perfusion (2021)
Journal Article
Correia, R., Gadsby, B., Korposh, S., Norris, A. M., Hayes-Gill, B. R., Sinha, R., …Morgan, S. P. (2022). Intra-tracheal multiplexed sensing of contact pressure and perfusion. Biomedical Optics Express, 13(1), 48-64. https://doi.org/10.1364/BOE.442165

Incorrect endotracheal tube (ETT) cuff inflation pressure causes significant problems for intubated patients. The technical development and first in vivo use of a smart ETT for measurements at the cuff-trachea interface during mechanical ventilation... Read More about Intra-tracheal multiplexed sensing of contact pressure and perfusion.

Localised plasmonic hybridisation mode optical fibre sensing of relative humidity (2021)
Journal Article
Liu, L. L., Korposh, S., Gomez, D., Correia, R., Hayes-Gill, B. R., & Morgan, S. P. (2022). Localised plasmonic hybridisation mode optical fibre sensing of relative humidity. Sensors and Actuators B: Chemical, 353, Article 131157. https://doi.org/10.1016/j.snb.2021.131157

This work reports an optical fibre probe functionalised with ‘cotton-shaped’ gold-silica nanostructures for relative humidity (RH) monitoring. The sensor response utilises the localised surface plasmon resonance (LSPR) of self-assembled nanostructure... Read More about Localised plasmonic hybridisation mode optical fibre sensing of relative humidity.

A single-film fiber optical sensor for simultaneous measurement of carbon dioxide and relative humidity (2021)
Journal Article
Liu, L. L., Morgan, S. P., Correia, R., & Korposh, S. (2022). A single-film fiber optical sensor for simultaneous measurement of carbon dioxide and relative humidity. Optics and Laser Technology, 147, Article 107696. https://doi.org/10.1016/j.optlastec.2021.107696

Colorimetric measurement is a versatile, low-cost method for bio-/chemical sensing and that has importance in biomedical applications. General carbon dioxide (CO2) sensors based on colorimetric change of a pH indicator report only one parameter at a... Read More about A single-film fiber optical sensor for simultaneous measurement of carbon dioxide and relative humidity.

Optical Fibre Sensor for Capillary Refill Time and Contact Pressure Measurements under the Foot (2021)
Journal Article
Ballaji, H. K., Correia, R., Liu, C., Korposh, S., Hayes-Gill, B. R., Musgrove, A., & Morgan, S. P. (2021). Optical Fibre Sensor for Capillary Refill Time and Contact Pressure Measurements under the Foot. Sensors, 21(18), Article 6072. https://doi.org/10.3390/s21186072

Capillary refill time (CRT) refers to the time taken for body tissue to regain its colour after an applied blanching pressure is released. Usually, pressure is manually applied and not measured. Upon release of pressure, simple mental counting is typ... Read More about Optical Fibre Sensor for Capillary Refill Time and Contact Pressure Measurements under the Foot.

Optical fibre Sensor for Simultaneous Temperature and Relative Humidity Measurement: Towards Absolute Humidity Evaluation (2021)
Journal Article
He, C., Korposh, S., Correia, R., Liu, L., Hayes-Gill, B. R., & Morgan, S. P. (2021). Optical fibre Sensor for Simultaneous Temperature and Relative Humidity Measurement: Towards Absolute Humidity Evaluation. Sensors and Actuators B: Chemical, 344, Article 130154. https://doi.org/10.1016/j.snb.2021.130154

Temperature and humidity are essential parameters in monitoring the health of patients in critical care. An optical fibre sensor has been developed for simultaneous measurement of relative humidity (RH) and temperature at a single optical fibre tip b... Read More about Optical fibre Sensor for Simultaneous Temperature and Relative Humidity Measurement: Towards Absolute Humidity Evaluation.

Chemically functionalised suspended-core fibre for ammonia gas detection (2021)
Journal Article
Liu, L., Tang, Z., He, C., Korposh, S., Lou, S., & Morgan, S. P. (2021). Chemically functionalised suspended-core fibre for ammonia gas detection. Journal of Lightwave Technology, 39(15), 5197-5205. https://doi.org/10.1109/JLT.2021.3083094

An optical fibre ammonia gas sensor utilising a functionalised four-leaf-clover-shaped suspended-core fibre (SCF) is demonstrated. The fibre is functionalised by depositing a thin layer of an ammonia sensitive dye (tetraphenylporphyrin tetrasulfonic... Read More about Chemically functionalised suspended-core fibre for ammonia gas detection.

Non-invasive cuff-less blood pressure estimation using a hybrid deep learning model (2021)
Journal Article
Yang, S., Zhang, Y., Cho, S., Correia, R., & Morgan, S. P. (2021). Non-invasive cuff-less blood pressure estimation using a hybrid deep learning model. Optical and Quantum Electronics, 53(2), Article 93. https://doi.org/10.1007/s11082-020-02667-0

Conventional blood pressure (BP) measurement methods have different drawbacks such as being invasive, cuff-based or requiring manual operations. There is significant interest in the development of non-invasive, cuff-less and continual BP measurement... Read More about Non-invasive cuff-less blood pressure estimation using a hybrid deep learning model.

Carboxyl-fentanyl detection using optical fibre grating-based sensors functionalised with molecularly imprinted nanoparticles (2021)
Journal Article
Liu, L. L., Grillo, F., Canfarotta, F., Whitcombe, M., Morgan, S. P., Piletsky, S., …Korposh, S. (2021). Carboxyl-fentanyl detection using optical fibre grating-based sensors functionalised with molecularly imprinted nanoparticles. Biosensors and Bioelectronics, 177, Article 113002. https://doi.org/10.1016/j.bios.2021.113002

Butyrylfentanyl is a new designer drug reported with growing use and related deaths. Routine toxicological analyses of this novel synthetic opioid drug have not been established yet. This work reports a fibre optic sensor that measures carboxyl-fenta... Read More about Carboxyl-fentanyl detection using optical fibre grating-based sensors functionalised with molecularly imprinted nanoparticles.

Development and validation of a novel fibre-optic respiratory rate sensor (FiRRS) integrated in oxygen delivery devices (2021)
Journal Article
Sinha, R., Hernandez, F., He, C., Korposh, S., Correia, R. N. G., Norris, A., …Morgan, S. P. (2021). Development and validation of a novel fibre-optic respiratory rate sensor (FiRRS) integrated in oxygen delivery devices. Journal of Physics D: Applied Physics, 54(12), https://doi.org/10.1088/1361-6463/abd061

© 2021 The Author(s). Respiratory rate (RR) monitoring provides crucial information on the overall health condition of patients and a reliable, low cost RR monitor for normal hospital inpatient or home use would be of significant benefit. The propose... Read More about Development and validation of a novel fibre-optic respiratory rate sensor (FiRRS) integrated in oxygen delivery devices.

A Textile Sleeve for Monitoring Oxygen Saturation Using Multichannel Optical Fibre Photoplethysmography (2020)
Journal Article
Ballaji, H. K., Correia, R., Korposh, S., Hayes-Gill, B. R., Hernandez, F. U., Salisbury, B., & Morgan, S. P. (2020). A Textile Sleeve for Monitoring Oxygen Saturation Using Multichannel Optical Fibre Photoplethysmography. Sensors, 20(22), Article 6568. https://doi.org/10.3390/s20226568

Textile-based systems are an attractive prospect for wearable technology as they can provide monitoring of key physiological parameters in a comfortable and unobtrusive form. A novel system based on multichannel optical fibre sensor probes integrated... Read More about A Textile Sleeve for Monitoring Oxygen Saturation Using Multichannel Optical Fibre Photoplethysmography.

A U-Shape Fibre-Optic pH Sensor Based on Hydrogen Bonding of Ethyl Cellulose with a Sol-Gel Matrix (2020)
Journal Article
Tang, Z., Gomez, D., He, C., Korposh, S., Morgan, S. P., Correia, R., …Liu, L. (2021). A U-Shape Fibre-Optic pH Sensor Based on Hydrogen Bonding of Ethyl Cellulose with a Sol-Gel Matrix. Journal of Lightwave Technology, 39(5), 1557-1564. https://doi.org/10.1109/JLT.2020.3034563

© 1983-2012 IEEE. Development of a biocompatible pH sensor is of importance in biomedical applications, particularly for in vivo measurement, providing necessary information for clinical diagnosis and treatment such as chronic wounds and foetal acido... Read More about A U-Shape Fibre-Optic pH Sensor Based on Hydrogen Bonding of Ethyl Cellulose with a Sol-Gel Matrix.

Surface polymer imprinted optical fibre sensor for dose detection of dabrafenib (2020)
Journal Article
He, C., Ledezma, U. H., Gurnani, P., Albelha, T., Thurecht, K. J., Correia, R., …Korposh, S. (2020). Surface polymer imprinted optical fibre sensor for dose detection of dabrafenib. Analyst, 145(13), 4504-4511. https://doi.org/10.1039/d0an00434k

© 2020 The Royal Society of Chemistry. Dabrafenib is one of the most widely used of the new generation of targeted anti-cancer drugs. However, its therapeutic window varies for different patients and so there is an unmet need for methods to monitor t... Read More about Surface polymer imprinted optical fibre sensor for dose detection of dabrafenib.

Accurate neonatal heart rate monitoring using a new wireless, cap mounted device (2020)
Journal Article
Henry, C., Shipley, L., Ward, C., Mirahmadi, S., Liu, C., Morgan, S., …Sharkey, D. (2020). Accurate neonatal heart rate monitoring using a new wireless, cap mounted device. Acta Paediatrica, 110(1), 72-78. https://doi.org/10.1111/apa.15303

© 2020 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica Aim: A device for newborn heart rate (HR) monitoring at birth that is compatible with delayed cord clamping and minimises hypothermia r... Read More about Accurate neonatal heart rate monitoring using a new wireless, cap mounted device.

Real-Time Humidity Measurement during Sports Activity using Optical Fibre Sensing (2020)
Journal Article
He, C., Korposh, S., Hernandez, F. U., Liu, L., Correia, R., Hayes-Gill, B. R., & Morgan, S. P. (2020). Real-Time Humidity Measurement during Sports Activity using Optical Fibre Sensing. Sensors, 20(7), Article 1904. https://doi.org/10.3390/s20071904

An optical fibre sensor for monitoring relative humidity (RH) changes during exercise is demonstrated. The humidity sensor comprises a tip coating of poly (allylamine hydrochloride) (PAH)/silica nanoparticles (SiO2 NPs) deposited using the layer-by-l... Read More about Real-Time Humidity Measurement during Sports Activity using Optical Fibre Sensing.

Optical fibre sensor for simultaneous measurement of capillary refill time and contact pressure (2020)
Journal Article
Liu, C., Correia, R., Ballaji, H., Korposh, S., Hayes‐gill, B., & Morgan, S. (2020). Optical fibre sensor for simultaneous measurement of capillary refill time and contact pressure. Sensors, 20(5), Article 1388. https://doi.org/10.3390/s20051388

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The widely applied capillary refill time (CRT) measurement is currently performed by manually applying pressure and using a stopwatch to record the time taken for the skin to recover its norma... Read More about Optical fibre sensor for simultaneous measurement of capillary refill time and contact pressure.

Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections (2020)
Journal Article
Kurmoo, Y., Hook, A. L., Harvey, D., Dubern, J., Williams, P., Morgan, S. P., …Alexander, M. R. (2020). Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections. Biomaterials Science, 8(5), 1464-1477. https://doi.org/10.1039/c9bm00875f

Real time monitoring of bacterial attachment to medical devices provides opportunities to detect early biofilm formation and instigate appropriate interventions before infection develops. This study utilises long period grating (LPG) optical fibre se... Read More about Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections.

Multi-parameter optical fibre sensing of gaseous ammonia and carbon dioxide (2019)
Journal Article
Liu, L., Morgan, S. P., Correia, R., Lee, S., & Korposh, S. (2020). Multi-parameter optical fibre sensing of gaseous ammonia and carbon dioxide. Journal of Lightwave Technology, 38(7), 2037-2045. https://doi.org/10.1109/jlt.2019.2953271

Ammonia (NH3) and carbon dioxide (CO2) are important breath biomarkers for diagnosis of renal and respiratory diseases. Simultaneous sensing of the two gases is useful for assessment of Helicobacter Pylori infection. This study introduces a multi-par... Read More about Multi-parameter optical fibre sensing of gaseous ammonia and carbon dioxide.

Numerical Simulation of a Scanning Illumination System for Deep Tissue Fluorescence Imaging (2019)
Journal Article
Zhang, Q., Grabowska, A. M., Clarke, P. A., & Morgan, S. P. (2019). Numerical Simulation of a Scanning Illumination System for Deep Tissue Fluorescence Imaging. Journal of Imaging, 5(11), Article 83. https://doi.org/10.3390/jimaging5110083

he spatial resolution and light detected in fluorescence imaging for small animals are limited by light scattering, absorption and autofluorescence. To address this, novel near-infrared fluorescent contrast agents and imaging configurations have been... Read More about Numerical Simulation of a Scanning Illumination System for Deep Tissue Fluorescence Imaging.

Simultaneous in situ temperature and relative humidity monitoring in mechanical ventilators using an array of functionalised optical fibre long period grating sensors (2019)
Journal Article
Hromadka, J., Hazlan, N. N. M., Hernandez, F. U., Correia, R., Norris, A., Morgan, S. P., & Korposh, S. (2019). Simultaneous in situ temperature and relative humidity monitoring in mechanical ventilators using an array of functionalised optical fibre long period grating sensors. Sensors and Actuators B: Chemical, 286, 306 - 314. https://doi.org/10.1016/j.snb.2019.01.124

An array of optical fibre long period gratings (LPGs) has been demonstrated for biomedical application to monitor temperature and relative humidity (RH) changes in the air delivered by a mechanical ventilator operating in different modes. The LPG arr... Read More about Simultaneous in situ temperature and relative humidity monitoring in mechanical ventilators using an array of functionalised optical fibre long period grating sensors.

A reflection-mode fibre-optic sensor for breath carbon dioxide measurement in healthcare (2018)
Journal Article
Liu, L., Hao, F., Morgan, S. P., Correia, R., Norris, A., & Korposh, S. (2019). A reflection-mode fibre-optic sensor for breath carbon dioxide measurement in healthcare. Sensing and Bio-Sensing Research, 22, Article 100254. https://doi.org/10.1016/j.sbsr.2018.100254

A reflection-mode carbon dioxide (CO2) fibre optic sensor (FOS) is developed based on the colorimetric change of pH indicator dye thymol blue. The CO2 sensing film comprises thymol blue and tetramethylammonium hydroxide in the form of an ion pair dop... Read More about A reflection-mode fibre-optic sensor for breath carbon dioxide measurement in healthcare.

Investigation of the performance of hyperspectral imaging by principal component analysis in the prediction of healing of diabetic foot ulcers (2018)
Journal Article
Yang, Q., Sun, S., Jeffcoate, W., Clark, D., Musgove, A., Game, F., & Morgan, S. (2018). Investigation of the performance of hyperspectral imaging by principal component analysis in the prediction of healing of diabetic foot ulcers. Journal of Imaging, 4(12), Article 144. https://doi.org/10.3390/jimaging4120144

Diabetic foot ulcers are a major complication of diabetes and present a considerable burden for both patients and health care providers. As healing often takes many months, a method of determining which ulcers would be most likely to heal would be of... Read More about Investigation of the performance of hyperspectral imaging by principal component analysis in the prediction of healing of diabetic foot ulcers.

Blood pressure estimation from photoplethysmogram and electrocardiogram signals using machine learning (2018)
Conference Proceeding
Yang, S., Zaki, W., Morgan, S., Cho, S., Correia, R., Wen, L., & Zhang, Y. (2018). Blood pressure estimation from photoplethysmogram and electrocardiogram signals using machine learning. In IET Doctoral Forum on Biomedical Engineering, Healthcare, Robotics and Artificial Intelligence 2018 (BRAIN 2018). https://doi.org/10.1049/cp.2018.1721

Blood pressure measurement is a significant part of preventive healthcare and has been widely used in clinical risk and disease management. However, conventional measurement does not provide continuous monitoring and sometimes is inconvenient with a... Read More about Blood pressure estimation from photoplethysmogram and electrocardiogram signals using machine learning.

Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score (2018)
Journal Article
Sinha, R., Correia, R., Gardner, D., Grau-Roma, L., de Brot, S., Hardman, J., …Norris, A. (2018). Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score. Laryngoscope Investigative Otolaryngology, 3(4), 257-262. https://doi.org/10.1002/lio2.168

Objectives: Postintubation laryngotracheal injury is common. Assessment of histopathological changes currently requires animal models. We set about developing a viable, resource effective animal model to study these effects and to develop a detailed... Read More about Mucosal injury following short term tracheal intubation: a novel animal model and composite injury score.

Biomedical application of optical fibre sensors (2018)
Journal Article
Correia, R., James, S., Lee, S., Morgan, S., & Korposh, S. (2018). Biomedical application of optical fibre sensors. Journal of Optics, 20(7), Article 073003. https://doi.org/10.1088/2040-8986/aac68d

Optical fibre sensors(OFS), as a result of their unique properties such as small size, no interference with electromagnetic radiation, high sensitivity and the ability to design multiplexed or distributed sensing systems, have found applications rang... Read More about Biomedical application of optical fibre sensors.

Highly sensitive label-free antibody detection using a long period fibre grating sensor (2018)
Journal Article
Liu, L., Marques, L., Correia, R., Morgan, S. P., Lee, S., Tighe, P. J., …Korposh, S. (2018). Highly sensitive label-free antibody detection using a long period fibre grating sensor. Sensors and Actuators B: Chemical, 271, 24-32. https://doi.org/10.1016/j.snb.2018.05.109

An optical fibre long period grating (LPG) biosensor is appealing in the detection of biomolecules because of the high sensitivity, label-free and real-time measurement. The miniaturized size, ability of remote sensing and immunity to electromagnetic... Read More about Highly sensitive label-free antibody detection using a long period fibre grating sensor.

Ultrasound-mediation of self-illuminating reporters improves imaging resolution in optically scattering media (2018)
Journal Article
Ahmad, J., Jayet, B., Hill, P. J., Mather, M. L., Dehghani, H., & Morgan, S. P. (in press). Ultrasound-mediation of self-illuminating reporters improves imaging resolution in optically scattering media. Biomedical Optics Express, 9(4), https://doi.org/10.1364/BOE.9.001664

In vivo imaging of self-illuminating bio-and chemiluminescent reporters is used to observe the physiology of small animals. However, strong light scattering by biological tissues results in poor spatial resolution of the optical imaging, which also d... Read More about Ultrasound-mediation of self-illuminating reporters improves imaging resolution in optically scattering media.

Incorporation of an ultrasound and model guided permissible region improves quantitative source recovery in bioluminescence tomography (2018)
Journal Article
Jayet, B., Morgan, S. P., & Dehgani, H. (in press). Incorporation of an ultrasound and model guided permissible region improves quantitative source recovery in bioluminescence tomography. Biomedical Optics Express, 9(3), https://doi.org/10.1364/BOE.9.001360

Bioluminescence imaging has shown great potential for studying and monitoring disease progression in small animal pre-clinical imaging. However, absolute bioluminescence source recovery through tomographic multi-wavelength measurements is often hinde... Read More about Incorporation of an ultrasound and model guided permissible region improves quantitative source recovery in bioluminescence tomography.

Highly sensitive volatile organic compounds vapour measurements using a long period grating optical fibre sensor coated with metal organic framework ZIF-8 (2018)
Journal Article
Hromadka, J., Tokay, B., Correia, R., Morgan, S. P., & Korposh, S. (2018). Highly sensitive volatile organic compounds vapour measurements using a long period grating optical fibre sensor coated with metal organic framework ZIF-8. Sensors and Actuators B: Chemical, 260, https://doi.org/10.1016/j.snb.2018.01.015

An optical fibre long period grating (LPG) based volatile organic compound (VOC) sensor coated with ZIF-8, a material from the zeolite imidazolate framework (ZIF) family, functional coating is presented. ZIF-8 film was deposited onto the surface of t... Read More about Highly sensitive volatile organic compounds vapour measurements using a long period grating optical fibre sensor coated with metal organic framework ZIF-8.

Carbon dioxide measurements using long period grating optical fibre sensor coated with metal organic framework HKUST-1 (2017)
Journal Article
Hromadka, J., Tokay, B., Correia, R., Morgan, S. P., & Korposh, S. (2018). Carbon dioxide measurements using long period grating optical fibre sensor coated with metal organic framework HKUST-1. Sensors and Actuators B: Chemical, 255(3), https://doi.org/10.1016/j.snb.2017.09.041

An optical fibre long period grating (LPG) based carbon dioxide (CO2) sensor coated with HKUST-1, a material from the metal organic framework family, functional coating is presented. In-situ crystallization and layer by layer (LbL) techniques of HKUS... Read More about Carbon dioxide measurements using long period grating optical fibre sensor coated with metal organic framework HKUST-1.

Polymeric optical fibre sensor coated by SiO2 nanoparticles for humidity sensing in the skin microenvironment (2017)
Journal Article
Gomez, D., Morgan, S. P., Hayes-Gill, B. R., Correia, R., & Korposh, S. (2018). Polymeric optical fibre sensor coated by SiO2 nanoparticles for humidity sensing in the skin microenvironment. Sensors and Actuators B: Chemical, 254, 887-895. https://doi.org/10.1016/j.snb.2017.07.191

The sensitivity of a low-cost polymeric optical fibre humidity sensor based on transmittance changes due to evanescent wave absorption is reported using test measurements in an environmental chamber and of the skin. The layer-by-layer method was used... Read More about Polymeric optical fibre sensor coated by SiO2 nanoparticles for humidity sensing in the skin microenvironment.

Nanoscale ultrasound-switchable FRET based liposomes for near-infrared fluorescence imaging in optically turbid media (2017)
Journal Article
Zhang, Q., Morgan, S. P., & Mather, M. L. (2017). Nanoscale ultrasound-switchable FRET based liposomes for near-infrared fluorescence imaging in optically turbid media. Small, 13(33), Article 1602895. https://doi.org/10.1002/smll.201602895

A new approach to fluorescence imaging in optically turbid media centered on the use of nanoscale ultrasound-switchable FRET based liposome contrast agents is reported. Liposomes containing lipophilic carbocyanine dyes as FRET pairs with emission wav... Read More about Nanoscale ultrasound-switchable FRET based liposomes for near-infrared fluorescence imaging in optically turbid media.

Ultrasound modulation of bioluminescence generated inside a turbid medium (2017)
Conference Proceeding
Ahmad, J., Jayet, B., Hill, P. J., Mather, M. L., Dehghani, H., & Morgan, S. P. (2017). Ultrasound modulation of bioluminescence generated inside a turbid medium. In A. A. Oraevsky, & L. V. Wang (Eds.), Proceedings SPIE 10064: Photons Plus Ultrasound: Imaging and Sensing 2017. https://doi.org/10.1117/12.2251349

In vivo bioluminescence imaging (BLI) has poor spatial resolution owing to strong light scattering by tissue, which also affects quantitative accuracy. This paper proposes a hybrid acousto-optic imaging platform that images bioluminescence modulated... Read More about Ultrasound modulation of bioluminescence generated inside a turbid medium.

Ultrasound induced fluorescence of nanoscale liposome contrast agents (2016)
Journal Article
Zhang, Q., Morgan, S. P., O’Shea, P., & Mather, M. L. (2016). Ultrasound induced fluorescence of nanoscale liposome contrast agents. PLoS ONE, 11(7), 1-15. https://doi.org/10.1371/journal.pone.0159742

A new imaging contrast agent is reported that provides an increased fluorescent signal upon application of ultrasound (US). Liposomes containing lipids labelled with pyrene were optically excited and the excimer fluorescence emission intensity was de... Read More about Ultrasound induced fluorescence of nanoscale liposome contrast agents.

Highly sensitive contact pressure measurements using FBG patch in endotracheal tube cuff (2016)
Journal Article
Correia, R., Blackman, O. R., Hernandez, F. U., Korposh, S., Morgan, S. P., Hayes-Gill, B. R., …Norris, A. (2016). Highly sensitive contact pressure measurements using FBG patch in endotracheal tube cuff. Proceedings of SPIE, 9916, Article 99161F. https://doi.org/10.1117/12.2236859

A method for measuring the contact pressure between an endotracheal tube cuff and the trachea was designed and developed by using a fibre Bragg grating (FBG) based optical fibre sensor. The FBG sensor is encased in an epoxy based UV-cured cuboid patc... Read More about Highly sensitive contact pressure measurements using FBG patch in endotracheal tube cuff.

Simultaneous temperature and humidity measurements in a mechanical ventilator using an optical fibre sensor (2016)
Journal Article
Hernandez, F., Correia, R., Morgan, S., Hayes-Gill, B., Evans, D., Sinha, R., …Korposh, S. (2016). Simultaneous temperature and humidity measurements in a mechanical ventilator using an optical fibre sensor. Proceedings of SPIE, 9916, Article 99160C. https://doi.org/10.1117/12.2236850

An optical fibre sensor for simultaneous temperature and humidity measurements consisting of one fibre Bragg grating (FBG) to measure temperature and a mesoporous film of bilayers of Poly(allylamine hydrochloride)(PAH) and silica (SiO2) nanoparticles... Read More about Simultaneous temperature and humidity measurements in a mechanical ventilator using an optical fibre sensor.

Comparison of laser Doppler and laser speckle contrast imaging using a concurrent processing system (2016)
Journal Article
Sun, S., Hayes-Gill, B. R., He, D., Zhu, Y., Huynh, N. T., & Morgan, S. P. (2016). Comparison of laser Doppler and laser speckle contrast imaging using a concurrent processing system. Optics and Lasers in Engineering, 83, https://doi.org/10.1016/j.optlaseng.2016.02.021

Full field laser Doppler imaging (LDI) and single exposure laser speckle contrast imaging (LSCI) are directly compared using a novel instrument which can concurrently image blood flow using both LDI and LSCI signal processing. Incorporating a commerc... Read More about Comparison of laser Doppler and laser speckle contrast imaging using a concurrent processing system.

Characterization and use of a fiber optic sensor based on PAH/SiO2 film for humidity sensing in ventilator care equipment (2016)
Journal Article
Hernandez, F. U., Morgan, S. P., Hayes-Gill, B. R., Harvey, D., Kinnear, W., Norris, A., …Korposh, S. (2016). Characterization and use of a fiber optic sensor based on PAH/SiO2 film for humidity sensing in ventilator care equipment. IEEE Transactions on Biomedical Engineering, 63(9), 1985-1992. https://doi.org/10.1109/TBME.2016.2521662

Objective: To develop a compact probe that can be used to monitor humidity in ventilator care equipment. A mesoporous film of alternate layers of Poly(allylamine hydrochloride) (PAH) and silica (SiO2) nanoparticles (bilayers), deposited onto an optic... Read More about Characterization and use of a fiber optic sensor based on PAH/SiO2 film for humidity sensing in ventilator care equipment.

Multi-exposure laser speckle contrast imaging using a high frame rate CMOS sensor with a field programmable gate array (2015)
Journal Article
Sun, S., Hayes-Gill, B. R., He, D., Zhu, Y., & Morgan, S. P. (2015). Multi-exposure laser speckle contrast imaging using a high frame rate CMOS sensor with a field programmable gate array. Optics Letters, 40(20), https://doi.org/10.1364/OL.40.004587

A system has been developed in which multi-exposure Laser Speckle Contrast Imaging (LSCI) is implemented using a high frame rate CMOS imaging sensor chip. Processing is performed using a Field Programmable Gate Array (FPGA). The system allows differe... Read More about Multi-exposure laser speckle contrast imaging using a high frame rate CMOS sensor with a field programmable gate array.

Highly sensitive optical fibre long period grating biosensor anchored with silica core gold shell nanoparticles (2015)
Journal Article
Marques, L. M., Hernandez, F. U., James, S. W., Morgan, S. P., Clark, M., Tatam, R. P., & Korposh, S. (2016). Highly sensitive optical fibre long period grating biosensor anchored with silica core gold shell nanoparticles. Biosensors and Bioelectronics, 75, https://doi.org/10.1016/j.bios.2015.08.046

An optical fibre long period grating (LPG), modified with a coating of silica core gold shell (SiO2:Au) nanoparticles (NPs) deposited using the layer-by-layer method, was employed for the development of a biosensor. The SiO2:Au NPs were electrostatic... Read More about Highly sensitive optical fibre long period grating biosensor anchored with silica core gold shell nanoparticles.

Government policy and healthcare management: proposal of a shared decision-making model (2015)
Journal Article
Petrillo, A., Felice, F. D., Vanzanella, C., Crispino, F., Martin, J. L., Craven, M. P., …Pecchia, L. (2015). Government policy and healthcare management: proposal of a shared decision-making model. International Journal of Management and Decision Making, 14(3), https://doi.org/10.1504/IJMDM.2015.070757

As a consequence of the current economic crisis many changes have been introduced to health systems on national levels to reduce expenditure and to introduce more cost-effective methods. Then recent developments in medical technology have led to a sh... Read More about Government policy and healthcare management: proposal of a shared decision-making model.

A single-chip CMOS pulse oximeter with on-chip lock-in detection (2015)
Journal Article
He, D., Morgan, S. P., Trachanis, D., van Hese, J., Drogoudis, D., Fummi, F., …Hayes-Gill, B. R. (2015). A single-chip CMOS pulse oximeter with on-chip lock-in detection. Sensors, 15(7), 17076-17088. https://doi.org/10.3390/s150717076

Pulse oximetry is a noninvasive and continuous method for monitoring the blood oxygen saturation level. This paper presents the design and testing of a single-chip pulse oximeter fabricated in a 0.35 µm CMOS process. The chip includes photodiode, tra... Read More about A single-chip CMOS pulse oximeter with on-chip lock-in detection.

Numerical investigation of the mechanisms of ultrasound-modulated bioluminescence tomography (2015)
Journal Article
Zhang, Q., Mather, M., & Morgan, S. P. (2015). Numerical investigation of the mechanisms of ultrasound-modulated bioluminescence tomography. IEEE Transactions on Biomedical Engineering, 62(9), https://doi.org/10.1109/TBME.2015.2405415

Objective: A hybrid imaging technique, Ultrasound Modulated Luminescence Tomography, that uses ultrasound to modulate diffusely propagating light has been shown to improve the spatial resolution of optical images. This paper is to investigate the und... Read More about Numerical investigation of the mechanisms of ultrasound-modulated bioluminescence tomography.

Post-processing of polymer foam tissue scaffolds with high power ultrasound: A route to increased pore interconnectivity, pore size and fluid transport (2013)
Journal Article
Watson, N. J., Johal, R. K., Glover, Z., Reinwald, Y., White, L. J., Ghaemmaghami, A. M., …Parker, N. G. (2013). Post-processing of polymer foam tissue scaffolds with high power ultrasound: A route to increased pore interconnectivity, pore size and fluid transport. Materials Science and Engineering: C, 33(8), 4825-4832. https://doi.org/10.1016/j.msec.2013.07.046

The aimof this work is to demonstrate that the structural and fluidic properties of polymer foamtissue scaffolds, post-fabrication but prior to the introduction of cells, can be engineered via exposure to high power ultrasound. Our analysis is suppor... Read More about Post-processing of polymer foam tissue scaffolds with high power ultrasound: A route to increased pore interconnectivity, pore size and fluid transport.

Laser Doppler blood flow imaging using a CMOS imaging sensor with on-chip signal processing (2013)
Journal Article
He, D., Nguyen, H. C., Hayes-Gill, B. R., Zhu, Y., Crowe, J. A., Gill, C., …Morgan, S. P. (2013). Laser Doppler blood flow imaging using a CMOS imaging sensor with on-chip signal processing. Sensors, 13(9), https://doi.org/10.3390/s130912632

The first fully integrated 2D CMOS imaging sensor with on-chip signal processing for applications in laser Doppler blood flow (LDBF) imaging has been designed and tested. To obtain a space efficient design over 64 × 64 pixels means that standard proc... Read More about Laser Doppler blood flow imaging using a CMOS imaging sensor with on-chip signal processing.

Pulsed ultrasound modulated optical tomography utilizing the harmonic response of lock-in detection (2013)
Journal Article
Ruan, H., Mather, M., & Morgan, S. P. (2013). Pulsed ultrasound modulated optical tomography utilizing the harmonic response of lock-in detection. Applied Optics, 52(19), https://doi.org/10.1364/AO.52.004755

Ultrasound modulated optical tomography (USMOT) can image the optical properties of a scattering medium at a spatial resolution approaching that of ultrasound (US). A lock-in parallel speckle detection technique is proposed to detect pulsed US modu... Read More about Pulsed ultrasound modulated optical tomography utilizing the harmonic response of lock-in detection.

Pulsed ultrasound modulated optical tomography with harmonic lock-in holography detection (2013)
Journal Article
Ruan, H., Mather, M., & Morgan, S. P. (2013). Pulsed ultrasound modulated optical tomography with harmonic lock-in holography detection. Journal of the Optical Society of America A, 30(7), https://doi.org/10.1364/JOSAA.30.001409

A method that uses digital heterodyne holography reconstruction to extract scattered light modulated by a singlecycle ultrasound (US) burst is demonstrated and analyzed. An US burst is used to shift the pulsed laser frequency by a series of discrete... Read More about Pulsed ultrasound modulated optical tomography with harmonic lock-in holography detection.

User needs elicitation via analytic hierarchy process (AHP): a case study on a Computed Tomography (CT) scanner (2013)
Journal Article
Pecchia, L., Martin, J. L., Ragozzino, A., Vanzanella, C., Scognamiglio, A., Mirarchi, L., & Morgan, S. P. (2013). User needs elicitation via analytic hierarchy process (AHP): a case study on a Computed Tomography (CT) scanner. BMC Medical Informatics and Decision Making, 13(2), https://doi.org/10.1186/1472-6947-13-2

Background: The rigorous elicitation of user needs is a crucial step for both medical device design and purchasing. However, user needs elicitation is often based on qualitative methods whose findings can be difficult to integrate into medical decisi... Read More about User needs elicitation via analytic hierarchy process (AHP): a case study on a Computed Tomography (CT) scanner.

Engaging with economic evaluation methods: insights from small and medium enterprises in the UK medical devices industry after training workshops (2012)
Journal Article
Craven, M. P., Allsop, M. J., Morgan, S. P., & Martin, J. L. (2012). Engaging with economic evaluation methods: insights from small and medium enterprises in the UK medical devices industry after training workshops. Health Research Policy and Systems, 10(29), https://doi.org/10.1186/1478-4505-10-29

Background With increased governmental interest in value assessment of technologies and where medical device manufacturers are finding it increasingly necessary to become more familiar with economic evaluation methods, the study sought to explore... Read More about Engaging with economic evaluation methods: insights from small and medium enterprises in the UK medical devices industry after training workshops.

Can health economics aid decision making in healthcare innovation in academia? (2012)
Journal Article
Lu, B., Martin, J. L., Craven, M. P., & Morgan, S. P. (2012). Can health economics aid decision making in healthcare innovation in academia?. International Journal of Technology Transfer and Commercialisation, 11(1/2), https://doi.org/10.1504/IJTTC.2012.043911

Health economics is extensively used by reimbursement agencies to make decisions on whether to adopt new medical technologies. It is also used by the healthcare industry as an aid to decision making during product development. This paper proposes tha... Read More about Can health economics aid decision making in healthcare innovation in academia?.

A user-centred approach to requirements elicitation in medical device development: a case study from an industry perspective (2012)
Journal Article
Martin, J. L., Clarke, D. J., Crowe, J. A., Morgan, S. P., & Murphy, E. (2012). A user-centred approach to requirements elicitation in medical device development: a case study from an industry perspective. Applied Ergonomics, 43(1), https://doi.org/10.1016/j.apergo.2011.05.002

The healthcare industry is dependent upon the provision of well designed medical devices. To achieve this it is recommended that user-centred design should begin early, and continue throughout device development. This is a challenge, particularly f... Read More about A user-centred approach to requirements elicitation in medical device development: a case study from an industry perspective.

CMOS sensors for imaging blood flow (2010)
Journal Article
Morgan, S., Hayes-Gill, B., & Crowe, J. (2010). CMOS sensors for imaging blood flow. Optics and Photonics News, 21(1), 32-37. https://doi.org/10.1364/OPN.21.1.000032

Smart CMOS sensors can extract parameters of interest from incoming signals at the sensor and therefore overcome the data bottleneck between sensor and processor. This enables full-field laser Doppler blood flow imaging to be obtained at a frame rate... Read More about CMOS sensors for imaging blood flow.

Deploying a spreadsheet tool for early economic value assessment of medical device innovations with healthcare decision makers (2009)
Journal Article
Craven, M. P., Morgan, S. P., Crowe, J. A., & Lu, B. (2009). Deploying a spreadsheet tool for early economic value assessment of medical device innovations with healthcare decision makers. International Journal of Healthcare Management, 2(3), https://doi.org/10.1179/175330309791011055

Early stage evaluation of medical device innovations is important for healthcare decision-makers as much as for manufacturers, meaning that a wider application of a basic cost-effectiveness analysis is becoming necessary outside the usual expert base... Read More about Deploying a spreadsheet tool for early economic value assessment of medical device innovations with healthcare decision makers.

The design and characterisation of an optical VLSI processor for real time centroid detection (2002)
Journal Article
Pui, B. H., Hayes-Gill, B., Clark, M., Somekh, M., See, C., Piéri, J. F., …Ng, A. (2002). The design and characterisation of an optical VLSI processor for real time centroid detection. Analog Integrated Circuits and Signal Processing, 32(1), 67-75. https://doi.org/10.1023/A%3A1016075825331

The integration of photo-detectors onto a standard CMOS integrated circuit is presented. This device provides the optical front end for a real time centroid detection system to be used as part of a larger system for implementing a Shack-Hartmann wave... Read More about The design and characterisation of an optical VLSI processor for real time centroid detection.

The Design of a Real Time VLSI Optical Centroid Processor (2002)
Conference Proceeding
Pui, B. H., Hayes-Gill, B., Clark, M., Somekh, M., See, C., Morgan, S., & Ng, A. (2002). The Design of a Real Time VLSI Optical Centroid Processor. In IEEE Sensors 2002 : first IEEE International Conference on Sensors. https://doi.org/10.1109/ICSENS.2002.1036977

A real time VLSI optical centroid processor has been developed as part of a larger Shack-Hartmann wavefront sensor system for applications in adaptive optics. The implementation of the optical centroid detection system was demonstrated successfully u... Read More about The Design of a Real Time VLSI Optical Centroid Processor.

The design and characterisation of an optical VLSI processor for real time centroid detection (2001)
Journal Article
Boon Hean Pui, , Hayes-Gill, B., Clark, M., Somekh, M., See, C., Piéri, J. F., …Ng, A. (2001). The design and characterisation of an optical VLSI processor for real time centroid detection. Proceedings of SPIE, 4408, 73-80. https://doi.org/10.1117/12.425338

The integration of photo-detectors onto a standard CMOS integrated circuit is presented. This device provides the optical front end for a real time centroid detection system to be used as part of a larger system for implementing a Shack-Hartmann wave... Read More about The design and characterisation of an optical VLSI processor for real time centroid detection.