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U-shape functionalized optical fibre sensors for measurement of anaesthetic propofol

Hernandez, Francisco U.; Wang, T.; Lee, Seung Woo; Norris, A.; Liu, Liang Liang; Hayes-Gill, B. R.; Morgan, S. P.; Korposh, S.

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T. Wang

Seung Woo Lee

A. Norris

Liang Liang Liu

Professor of Electronic Systems and Medical Devices

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Professor of Photonics Instrumentation


Propofol is used widely for intravenous anaesthesia during surgery and sedation in critical care. There is no method currently to assay the concentration of propofol in plasma in real time. The ability to do so would significantly improve patient safety. A novel approach to propofol assay consisting of Beta-Cyclodextrin (β−CD) assisted propofol-imprinting onto TiO2 films deposited on U-shaped optical fibres was used for the measurement of propofol in aqueous solutions. The sensing mechanism is based on the measurement of the refractive index change induced by the removing and binding of the propofol from and to the β−CD/propofol complex embedded onto TiO2 films, respectively. Complexation between host (β−CD) and guest (propofol) was confirmed by nuclear magnetic resonance (NMR) spectroscopy, UV-Vis spectroscopy, and by Attenuated Total Reflectance- Fourier-transform infrared spectroscopy (FTIR). The developed sensors presented Langmuir adsorption in the mM range and the lowest concentration detected was 0.69 μM= 0.12 μg/ml. The approach can be replicated for other compounds in other biomedical applications such as vitamins, hormones, or drugs.


Hernandez, F. U., Wang, T., Lee, S. W., Norris, A., Liu, L. L., Hayes-Gill, B. R., …Korposh, S. (2022). U-shape functionalized optical fibre sensors for measurement of anaesthetic propofol. Sensors and Actuators B: Chemical, 372, Article 132653.

Journal Article Type Article
Acceptance Date Sep 9, 2022
Online Publication Date Sep 13, 2022
Publication Date Dec 1, 2022
Deposit Date Oct 13, 2022
Publicly Available Date Oct 13, 2022
Journal Sensors and Actuators B: Chemical
Print ISSN 0925-4005
Publisher Elsevier BV
Peer Reviewed Peer Reviewed
Volume 372
Article Number 132653
Keywords Materials Chemistry; Electrical and Electronic Engineering; Metals and Alloys; Surfaces, Coatings and Films; Condensed Matter Physics; Instrumentation; Electronic, Optical and Magnetic Materials
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