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High sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS (2021)
Journal Article
Hook, A. L., Hogwood, J., Gray, E., Mulloy, B., & Merry, C. L. (2021). High sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS. Communications Chemistry, 4, Article 67. https://doi.org/10.1038/s42004-021-00506-1

Glycosaminoglycans (GAGs) are important biopolymers that differ in the sequence of saccharide units and in post polymerization alterations at various positions, making these complex molecules challenging to analyse. Here we describe an approach that... Read More about High sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS.

Diagnostic Concordance of Phyllodes Tumour of the Breast (2021)
Journal Article
Rakha, E., Mihai, R., Abbas, A., Bennett, R., Campora, M., Morena, P., …Ellis, I. (2021). Diagnostic Concordance of Phyllodes Tumour of the Breast. Histopathology, 79(4), 607-618. https://doi.org/10.1111/his.14397

Background: Phyllodes tumours (PT) are rare and distinct breast tumours, which span a morphological continuum. Classification into benign, borderline and malignant categories reflects their biology and clinical behaviour and is essential to guide man... Read More about Diagnostic Concordance of Phyllodes Tumour of the Breast.

Treatment patterns and outcomes of unfit and elderly patients with Mantle cell lymphoma unfit for standard immunochemotherapy: A UK and Ireland analysis (2021)
Journal Article
Rampotas, A., Wilson, M. R., Lomas, O., Denny, N., Leary, H., Ferguson, G., …Eyre, T. A. (2021). Treatment patterns and outcomes of unfit and elderly patients with Mantle cell lymphoma unfit for standard immunochemotherapy: A UK and Ireland analysis. British Journal of Haematology, 194(2), 365-377. https://doi.org/10.1111/bjh.17513

Mantle cell lymphoma (MCL) presenting in elderly, unfit patients represents a clinical challenge. Front-line ‘attenuated’ or low-intensity immunochemotherapy is often employed, although outcomes are relatively unexplored. We report outcomes of attenu... Read More about Treatment patterns and outcomes of unfit and elderly patients with Mantle cell lymphoma unfit for standard immunochemotherapy: A UK and Ireland analysis.

METTL3 Regulates Angiogenesis by Modulating let-7e-5p and miRNA-18a-5p Expression in Endothelial Cells (2021)
Journal Article
Chamorro-Jorganes, A., Sweaad, W. K., Katare, R., Besnier, M., Anwar, M., Beazley-Long, N., …Emanueli, C. (2021). METTL3 Regulates Angiogenesis by Modulating let-7e-5p and miRNA-18a-5p Expression in Endothelial Cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 41(6), e325-e337. https://doi.org/10.1161/atvbaha.121.316180

Objective: Postnatal angiogenesis is critical in vascular homeostasis and repair. m6A RNA methylation is emerging as a new layer for fine-tuning gene expression. Although the contribution of the m6A-catalyzing enzyme, METTL3 (methyltransferase-like... Read More about METTL3 Regulates Angiogenesis by Modulating let-7e-5p and miRNA-18a-5p Expression in Endothelial Cells.

Infection-related morbidity and mortality among older patients with DLBCL treated with full- or attenuated-dose R-CHOP (2021)
Journal Article
Eyre, T. A., Wilson, W., Kirkwood, A. A., Wolf, J., Hildyard, C., Plaschkes, H., …Hatton, C. S. R. (2021). Infection-related morbidity and mortality among older patients with DLBCL treated with full- or attenuated-dose R-CHOP. Blood Advances, 5(8), 2229-2236. https://doi.org/10.1182/bloodadvances.2021004286

Infection-related morbidity and mortality are increased in older patients with diffuse large B-cell lymphoma (DLBCL) compared with population-matched controls. Key predictive factors for infection-related hospitalization during treatment with rituxim... Read More about Infection-related morbidity and mortality among older patients with DLBCL treated with full- or attenuated-dose R-CHOP.

FLYWCH1, a Multi-Functional Zinc Finger Protein Contributes to the DNA Repair Pathway (2021)
Journal Article
Almozyan, S., Coulton, J., Babaei-Jadidi, R., & Nateri, A. S. (2021). FLYWCH1, a Multi-Functional Zinc Finger Protein Contributes to the DNA Repair Pathway. Cells, 10(4), Article 889. https://doi.org/10.3390/cells10040889

Over recent years, several Cys2-His2 (C2H2) domain-containing proteins have emerged as critical players in repairing DNA-double strand breaks. Human FLYWCH1 is a newly characterised nuclear transcription factor with (C2H2)-type zinc-finger DNA-bindin... Read More about FLYWCH1, a Multi-Functional Zinc Finger Protein Contributes to the DNA Repair Pathway.

RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancer (2021)
Journal Article
Sanz-Moreno, A., Palomeras, S., Pedersen, K., Morancho, B., Pascual, T., Galván, P., …Gonzalez-Suarez, E. (2021). RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancer. Breast Cancer Research, 23(1), Article 42. https://doi.org/10.1186/s13058-021-01390-2

Background Around 15–20% of primary breast cancers are characterized by HER2 protein overexpression and/or HER2 gene amplification. Despite the successful development of anti-HER2 drugs, intrinsic and acquired resistance represents a major hurdle. T... Read More about RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancer.

Prognostic significance of heat shock protein 90AA1 (HSP90?) in invasive breast cancer (2021)
Journal Article
Alsaeed, S. A., Toss, M., Alsaleem, M., Aleskandarany, M., Joseph, C., Kurozumi, S., …Rakha, E. (2022). Prognostic significance of heat shock protein 90AA1 (HSP90α) in invasive breast cancer. Journal of Clinical Pathology, 75(4), 263-269. https://doi.org/10.1136/jclinpath-2020-207106

Aims: The mechanisms that drive breast cancer (BC) progression and poor outcome are not fully understood. The human heat shock protein 90 alpha family class A member 1 (HSP90?) encoded by the HSP90 'A1 gene has a vital role in cellular responses to s... Read More about Prognostic significance of heat shock protein 90AA1 (HSP90?) in invasive breast cancer.

Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast Cancer Cells (2021)
Journal Article
Lu, X., Redon, C. E., Tang, W., Parvathaneni, S., Bokhari, B., Debnath, S., …Sharma, S. (2021). Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast Cancer Cells. Molecular and Cellular Biology, 41(4), e00515-20. https://doi.org/10.1128/mcb.00515-20

Susceptibility to breast cancer is significantly increased in individuals with germ line mutations in RECQ1 (also known as RECQL or RECQL1), a gene encoding a DNA helicase essential for genome maintenance. We previously reported that RECQ1 expression... Read More about Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast Cancer Cells.

Bioinspired artificial exosomes based on lipid nanoparticles carrying let-7b-5p promote angiogenesis in vitro and in vivo (2021)
Journal Article
Aday, S., Hazan-Halevy, I., Chamorro-Jorganes, A., Anwar, M., Goldsmith, M., Beazley-Long, N., …Emanueli, C. (2021). Bioinspired artificial exosomes based on lipid nanoparticles carrying let-7b-5p promote angiogenesis in vitro and in vivo. Molecular Therapy, 29(7), 2239-2252. https://doi.org/10.1016/j.ymthe.2021.03.015

MicroRNAs (miRNAs) regulate gene expression by post-transcriptional inhibition of target genes. Proangiogenic small extracellular vesicles (sEVs; popularly identified with the name “exosomes”) with a composite cargo of miRNAs are secreted by cultured... Read More about Bioinspired artificial exosomes based on lipid nanoparticles carrying let-7b-5p promote angiogenesis in vitro and in vivo.

The use of fluorescence correlation spectroscopy to monitor cell surface ?2?adrenoceptors at low expression levels in human embryonic stem cell?derived cardiomyocytes and fibroblasts (2021)
Journal Article
Goulding, J., Kondrashov, A., Mistry, S. J., Melarangi, T., Vo, N. T. N., Hoang, D. M., …Hill, S. J. (2021). The use of fluorescence correlation spectroscopy to monitor cell surface β2‐adrenoceptors at low expression levels in human embryonic stem cell‐derived cardiomyocytes and fibroblasts. FASEB Journal, 35(4), Article e21398. https://doi.org/10.1096/fj.202002268r

The importance of cell phenotype in determining the molecular mechanisms underlying ?2- adrenoceptor (?2AR) function has been noted previously when comparing responses in primary cells and recombinant model cell lines. Here, we have generated haploty... Read More about The use of fluorescence correlation spectroscopy to monitor cell surface ?2?adrenoceptors at low expression levels in human embryonic stem cell?derived cardiomyocytes and fibroblasts.

Genomic instability profiles at the single cell level in mouse colorectal cancers of defined genotypes (2021)
Journal Article
Dionellis, V. S., Norkin, M., Karamichali, A., Rossetti, G. G., Huelsken, J., Ordonez-Moran, P., & Halazonetis, T. D. (2021). Genomic instability profiles at the single cell level in mouse colorectal cancers of defined genotypes. Cancers, 13(6), Article 1267. https://doi.org/10.3390/cancers13061267

The genomes of many human CRCs have been sequenced, revealing a large number of genetic alterations. However, the molecular mechanisms underlying the accumulation of these alterations are still being debated. In this study, we examined colorectal tum... Read More about Genomic instability profiles at the single cell level in mouse colorectal cancers of defined genotypes.

The impact of tumour biology on the management of primary breast cancer in older women—based on a research programme in Nottingham (2021)
Journal Article
Parks, R. M., Green, A. R., & Cheung, K. (2021). The impact of tumour biology on the management of primary breast cancer in older women—based on a research programme in Nottingham. Annals of Breast Surgery, 5, Article 5. https://doi.org/10.21037/abs-20-130

The incidence of breast cancer increases with age. Average life expectancies are increasing; the older population is expanding globally. This presents a huge challenge on an international scale in the coming years as more older people are living with... Read More about The impact of tumour biology on the management of primary breast cancer in older women—based on a research programme in Nottingham.

Age-related biology of early-stage operable breast cancer and its impact on clinical outcome (2021)
Journal Article
Cheung, K. L., Ellis, I. O., Morgan, D. A., Rakha, E. A., Green, A. R., & Syed, B. M. (2021). Age-related biology of early-stage operable breast cancer and its impact on clinical outcome. Cancers, 13(6), Article 1417. https://doi.org/10.3390/cancers13061417

As age advances, breast cancer (BC) tends to change its biological characteristics. This study aimed to explore the natural progression of such changes. The study included 2383 women with clinically T0-2N0-1M0 BC, managed by primary surgery and optim... Read More about Age-related biology of early-stage operable breast cancer and its impact on clinical outcome.

A new view of macula densa cell microanatomy (2021)
Journal Article
Gyarmati, G., Shroff, U. N., Riquier-Brison, A., Kriz, W., Kaissling, B., Neal, C. R., …Peti-Peterdi, J. (2021). A new view of macula densa cell microanatomy. AJP - Renal Physiology, 320(3), F492-F504. https://doi.org/10.1152/ajprenal.00546.2020

Although macula densa (MD) cells are chief regulatory cells in the nephron with unique microanatomical features, they have been difficult to study in full detail due to their inaccessibility and limitations in earlier microscopy techniques. The prese... Read More about A new view of macula densa cell microanatomy.

Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease (2021)
Journal Article
Hall, C., Gehmlich, K., Denning, C., & Pavlovic, D. (2021). Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease. Journal of the American Heart Association, 10(5), Article e019338. https://doi.org/10.1161/jaha.120.019338

Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix in the heart, providing support to the contracting myocardium and contributing to a myriad of physiological signaling processes. Despite the importance o... Read More about Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease.

The ICON Trauma Study: The Impact of the COVID-19 lockdown on Major Trauma workload in the UK (2021)
Journal Article
Adiamah, A., Thompson, A., Lewis-Lloyd, C., Dickson, E., Blackburn, L., Moody, N., …Brooks, A. (2021). The ICON Trauma Study: The Impact of the COVID-19 lockdown on Major Trauma workload in the UK. European Journal of Trauma and Emergency Surgery, 47, 637–645. https://doi.org/10.1007/s00068-020-01593-w

Background The global pandemic caused by SARS-CoV-2 has impacted population health and care delivery worldwide. As information emerges regarding the impact of “lockdown measures” and changes to clinical practice worldwide; there is no comparative in... Read More about The ICON Trauma Study: The Impact of the COVID-19 lockdown on Major Trauma workload in the UK.