Professor KWOK_LEUNG CHEUNG KWOK_LEUNG.CHEUNG@NOTTINGHAM.AC.UK
Deputy Head of Education & Director of The Bmbs Medicine Programmes
Age-related biology of early-stage operable breast cancer and its impact on clinical outcome
Cheung, Kwok Leung; Ellis, Ian O.; Morgan, David A.L.; Rakha, Emad A.; Green, Andrew R.; Syed, Binafsha M.
Authors
Professor IAN ELLIS IAN.ELLIS@NOTTINGHAM.AC.UK
Professor of Cancer Pathology
David A.L. Morgan
EMAD RAKHA Emad.Rakha@nottingham.ac.uk
Professor of Breast Cancer Pathology
ANDREW GREEN ANDREW.GREEN@NOTTINGHAM.AC.UK
Associate Professor
Binafsha M. Syed
Abstract
As age advances, breast cancer (BC) tends to change its biological characteristics. This study aimed to explore the natural progression of such changes. The study included 2383 women with clinically T0-2N0-1M0 BC, managed by primary surgery and optimal adjuvant therapy in a dedicated BC facility. Tissue micro-arrays were constructed from their surgical specimens and indirect immunohistochemistry was used for analysis of a large panel (n = 16) of relevant biomarkers. There were significant changes in the pattern of expression of biomarkers related to luminal (oestrogen receptor (ER), progesterone receptors (PgR), human epidermal growth factor receptor (HER2), E-cadherin, MUC1, bcl2 CK7/8, CK18 and bcl2) and basal (CK5/6, CK14, p53 and Ki67) phenotypes, lymph node stage, histological grade and pathological size when decade-wise comparison was made (p < 0.05). The ages of 40 years and 70 years appeared to be the milestones marking a change of the pattern. There were significantly higher metastasis free and breast cancer specific survival rates among older women with ER positive tumours while there was no significant difference in the ER negative group according to age. Biological characteristics of BC show a pattern of change with advancing age, where 40 years and 70 years appear as important milestones. The pattern suggests 70 years as the less aggressive phase and 40–70 years being the transitional phase.
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 15, 2021 |
Online Publication Date | Mar 19, 2021 |
Publication Date | Mar 2, 2021 |
Deposit Date | Apr 13, 2021 |
Publicly Available Date | Apr 13, 2021 |
Journal | Cancers |
Electronic ISSN | 2072-6694 |
Publisher | MDPI |
Peer Reviewed | Peer Reviewed |
Volume | 13 |
Issue | 6 |
Article Number | 1417 |
DOI | https://doi.org/10.3390/cancers13061417 |
Keywords | Cancer Research; Oncology |
Public URL | https://nottingham-repository.worktribe.com/output/5403067 |
Publisher URL | https://www.mdpi.com/2072-6694/13/6/1417 |
Files
Age-Related Biology of Early-Stage Operable Breast Cancer
(9 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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