All Outputs (165)

ESCAPS study protocol: a feasibility randomised controlled trial of ‘Early electrical stimulation to the wrist extensors and wrist flexors to prevent the post-stroke complications of pain and contractures in the paretic arm’ (2016)
Journal Article
Fletcher-Smith, J. C., Walker, D., Sprigg, N., James, M., Walker, M. F., Allatt, K., …Pandyan, A. D. (2016). ESCAPS study protocol: a feasibility randomised controlled trial of ‘Early electrical stimulation to the wrist extensors and wrist flexors to prevent the post-stroke complications of pain and contractures in the paretic arm’. BMJ Open, 6(1), Article e010079. https://doi.org/10.1136/bmjopen-2015-010079

Introduction Approximately 70% of patients with stroke experience impaired arm function, which is persistent and disabling for an estimated 40%. Loss of function reduces independence in daily activities and impacts on quality of life. Muscles in thos... Read More about ESCAPS study protocol: a feasibility randomised controlled trial of ‘Early electrical stimulation to the wrist extensors and wrist flexors to prevent the post-stroke complications of pain and contractures in the paretic arm’.

Effect of treatment delay, stroke type, and thrombolysis on the effect of glyceryl trinitrate, a nitric oxide donor, on outcome after acute stroke: a systematic review and meta-analysis of individual patient from randomised trials (2016)
Journal Article
Bath, P. M., Woodhouse, L. J., Krishnan, K., Anderson, C., Berge, E., Ford, G. A., …Wardlaw, J. M. (2016). Effect of treatment delay, stroke type, and thrombolysis on the effect of glyceryl trinitrate, a nitric oxide donor, on outcome after acute stroke: a systematic review and meta-analysis of individual patient from randomised trials. Stroke Research and Treatment, 2016, https://doi.org/10.1155/2016/9706720

Background. Nitric oxide (NO) donors are a candidate treatment for acute stroke and two trials have suggested that they might improve outcome if administered within 4–6 hours of stroke onset. We assessed the safety and efficacy of NO donors using ind... Read More about Effect of treatment delay, stroke type, and thrombolysis on the effect of glyceryl trinitrate, a nitric oxide donor, on outcome after acute stroke: a systematic review and meta-analysis of individual patient from randomised trials.

Glyceryl Trinitrate for Acute Intracerebral Hemorrhage: Results From the Efficacy of Nitric Oxide in Stroke (ENOS) Trial, a Subgroup Analysis (2015)
Journal Article
Krishnan, K., Scutt, P., Woodhouse, L. J., Adami, A., Becker, J. L., Berge, E., …Bath, P. M. (in press). Glyceryl Trinitrate for Acute Intracerebral Hemorrhage: Results From the Efficacy of Nitric Oxide in Stroke (ENOS) Trial, a Subgroup Analysis. Stroke, 47(1), 44-52. https://doi.org/10.1161/strokeaha.115.010368

Background and purpose: The Efficacy of Nitric oxide in Stroke (ENOS) trial found that transdermal glyceryl trinitrate (GTN, a nitric oxide donor) lowered blood pressure but did not improve functional outcome in patients with acute stroke. However, G... Read More about Glyceryl Trinitrate for Acute Intracerebral Hemorrhage: Results From the Efficacy of Nitric Oxide in Stroke (ENOS) Trial, a Subgroup Analysis.

Baseline characteristics, analysis plan and report on feasibility for the Prevention Of Decline in Cognition After Stroke Trial (PODCAST) (2015)
Journal Article
Scutt, P., Blackburn, D., Krishnan, K., Ballard, C., Burns, A., Ford, G. A., …Bath, P. M. (2015). Baseline characteristics, analysis plan and report on feasibility for the Prevention Of Decline in Cognition After Stroke Trial (PODCAST). Trials, 16(1), Article 509. https://doi.org/10.1186/s13063-015-1033-2

Background A common complication after stroke is development of cognitive impairment and dementia. However, effective strategies for reducing the risk of developing these problems remain undefined. Potential strategies include intensive lowering o... Read More about Baseline characteristics, analysis plan and report on feasibility for the Prevention Of Decline in Cognition After Stroke Trial (PODCAST).

Effect of hyperacute administration (within 6 hours) of transdermal glyceryl trinitrate, a nitric oxide donor, on outcome after stroke (2015)
Journal Article
Woodhouse, L. J., Scutt, P., Krishnan, K., Berge, E., Gommans, J., Ntaios, G., …Bath, P. M. (2015). Effect of hyperacute administration (within 6 hours) of transdermal glyceryl trinitrate, a nitric oxide donor, on outcome after stroke. Stroke, 46(11), https://doi.org/10.1161/STROKEAHA.115.009647

Background and Purpose — Nitric oxide donors are candidate treatments for acute stroke, potentially through hemodynamic, reperfusion, and neuroprotectant effects, especially if given early. Although the large Efficacy of Nitric Oxide in Stroke (ENOS)... Read More about Effect of hyperacute administration (within 6 hours) of transdermal glyceryl trinitrate, a nitric oxide donor, on outcome after stroke.

Performance characteristics of methods for quantifying spontaneous intracerebral haemorrhage: data from the Efficacy of Nitric Oxide in Stroke (ENOS) trial (2015)
Journal Article
Krishnan, K., Mukhtar, S. F., Dineen, R., Lingard, J., Houlton, A., Walker, E., …Wardlaw, J. M. (2015). Performance characteristics of methods for quantifying spontaneous intracerebral haemorrhage: data from the Efficacy of Nitric Oxide in Stroke (ENOS) trial. Journal of Neurology, Neurosurgery and Psychiatry, 86(11), 1258-1266. https://doi.org/10.1136/jnnp-2014-309845

Background: Poor prognosis after intracerebral haemorrhage (ICH) is related to haemorrhage characteristics. Along with developing therapeutic interventions, we sought to understand the performance of haemorrhage descriptors in large clinical trials.... Read More about Performance characteristics of methods for quantifying spontaneous intracerebral haemorrhage: data from the Efficacy of Nitric Oxide in Stroke (ENOS) trial.

Statistical analysis plan for the ‘Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke’ (TARDIS) trial (2014)
Journal Article
Bath, P. M., Robson, K., Woodhouse, L. J., Sprigg, N., Dineen, R. A., & Pocock, S. J. (2015). Statistical analysis plan for the ‘Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke’ (TARDIS) trial. International Journal of Stroke, 10(3), https://doi.org/10.1111/ijs.12445

Rationale: Antiplatelet agents such as aspirin, clopidogrel and dipyridamole are effective in reducing the risk of recurrence after a stroke. Importantly, the risk of recurrence is highest immediately after the index event while antiplatelets cause b... Read More about Statistical analysis plan for the ‘Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke’ (TARDIS) trial.

Who should have a pre–discharge home assessment visit after a stroke? A qualitative study of occupational therapists' views (2014)
Journal Article
Whitehead, P. J., Fellows, K. R., Sprigg, N., Walker, M. F., & Drummond, A. E. (2014). Who should have a pre–discharge home assessment visit after a stroke? A qualitative study of occupational therapists' views. British Journal of Occupational Therapy, 77(8), https://doi.org/10.4276/030802214X14071472109752

Introduction: The number of patients who have a pre-discharge home assessment visit following a stroke has been reported to vary nationally. The purpose of this research was to explore the factors influencing occupational therapists' decisions to co... Read More about Who should have a pre–discharge home assessment visit after a stroke? A qualitative study of occupational therapists' views.

Relationship between Poststroke Cognition, Baseline Factors, and Functional Outcome: Data from “Efficacy of Nitric Oxide in Stroke” Trial (2014)
Journal Article
Ankolekar, S., Renton, C., Sare, G., Ellender, S., Sprigg, N., Wardlaw, J. M., & Bath, P. M. (2014). Relationship between Poststroke Cognition, Baseline Factors, and Functional Outcome: Data from “Efficacy of Nitric Oxide in Stroke” Trial. Journal of Stroke and Cerebrovascular Diseases, 23(7), 1821-1829. https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.04.022

Tranexamic Acid for Spontaneous Intracerebral Hemorrhage: A Randomized Controlled Pilot Trial (ISRCTN50867461) (2014)
Journal Article
Sprigg, N., Renton, C. J., Dineen, R. A., Kwong, Y., & Bath, P. M. (2014). Tranexamic Acid for Spontaneous Intracerebral Hemorrhage: A Randomized Controlled Pilot Trial (ISRCTN50867461). Journal of Stroke and Cerebrovascular Diseases, 23(6), 1312-1318. https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.11.007

Background: Spontaneous intracerebral hemorrhage (ICH) can be devastating, particularly if hematoma expansion (HE) occurs. Tranexamic acid (TA), an antifibrinolytic drug, significantly reduced mortality in bleeding patients after trauma in the large... Read More about Tranexamic Acid for Spontaneous Intracerebral Hemorrhage: A Randomized Controlled Pilot Trial (ISRCTN50867461).

Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions (2014)
Journal Article
Gibson, C. L., Srivastava, K., Sprigg, N., Bath, P. M., & Bayrakutan, U. (in press). Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions. Journal of Neurochemistry, 129(5), https://doi.org/10.1111/jnc.12681

Ischaemic strokes evoke blood–brain barrier (BBB) disruption and oedema formation through a series of mechanisms involving Rho-kinase activation. Using an animal model of human focal cerebral ischaemia, this study assessed and confirmed the therapeut... Read More about Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions.

Statistical analysis plan for the ‘Efficacy of Nitric Oxide in Stroke’ (ENOS) trial (2014)
Journal Article
Bath, P. M., Houlton, A., Woodhouse, L. J., Sprigg, N., Wardlaw, J. M., & Pocock, S. J. (in press). Statistical analysis plan for the ‘Efficacy of Nitric Oxide in Stroke’ (ENOS) trial. International Journal of Stroke, 9(3), https://doi.org/10.1111/ijs.12235

High blood pressure is common during the acute phase of stroke and is associated with a poor outcome. However, the management of high blood pressure remains unclear. The ‘Efficacy of Nitric Oxide in Stroke’ trial tested whether transdermal glyceryl t... Read More about Statistical analysis plan for the ‘Efficacy of Nitric Oxide in Stroke’ (ENOS) trial.

Occupational therapy predischarge home visits for patients with a stroke (HOVIS): results of a feasibility randomized controlled trial (2013)
Journal Article
Drummond, A., Whitehead, P., Fellows, K., Sprigg, N., Sampson, C. J., Edwards, C., & Lincoln, N. (2013). Occupational therapy predischarge home visits for patients with a stroke (HOVIS): results of a feasibility randomized controlled trial. Clinical Rehabilitation, 27(5),

Objective: To assess the feasibility of conducting a randomized controlled trial of occupational therapy predischarge home visits for people after stroke. Design: Randomized controlled trial and cohort study. We randomized eligible patients for whom... Read More about Occupational therapy predischarge home visits for patients with a stroke (HOVIS): results of a feasibility randomized controlled trial.

Occupational therapy pre-discharge HOme VIsits for patients with a Stroke (HOVIS): results of a randomised controlled trial (2012)
Journal Article
Drummond, A., Whitehead, P., Fellows, K., Sprigg, N., Sampson, C. J., Edwards, C., & Lincoln, N. (2012). Occupational therapy pre-discharge HOme VIsits for patients with a Stroke (HOVIS): results of a randomised controlled trial. Clinical Rehabilitation, https://doi.org/10.1177/0269215512462145

Objective To conduct a randomised controlled trial (RCT) of occupational therapy predischarge home visits for people after stroke in order to assess the feasibility of a definitive trial. Design Two studies; a randomised controlled trial and a coh... Read More about Occupational therapy pre-discharge HOme VIsits for patients with a Stroke (HOVIS): results of a randomised controlled trial.

Speeding stroke recovery? A systematic review of amphetamine after stroke (2009)
Journal Article
Sprigg, N., & Bath, P. M. (2009). Speeding stroke recovery? A systematic review of amphetamine after stroke. Journal of the Neurological Sciences, 285(1-2), 3-9. https://doi.org/10.1016/j.jns.2009.04.040

Introduction: The use of drugs to enhance recovery (“rehabilitation pharmacology”) has been assessed. Amphetamine can improve outcome in experimental models of stroke, and several small clinical trials have assessed its use in stroke. Methods: Elec... Read More about Speeding stroke recovery? A systematic review of amphetamine after stroke.

A systematic review of delays in seeking medical attention after transient ischaemic attack (2009)
Journal Article
Sprigg, N., Machili, C., Otter, M., Wilson, A., & Robinson, T. (2009). A systematic review of delays in seeking medical attention after transient ischaemic attack. Journal of Neurology, Neurosurgery and Psychiatry, 80(8), https://doi.org/10.1136/jnnp.2008.167924

Background: Prompt assessment and investigation of transient ischaemic attack (TIA) followed by early initiation of secondary prevention is effective in reducing recurrent stroke. Nevertheless, many patients are slow to seek medical advice after... Read More about A systematic review of delays in seeking medical attention after transient ischaemic attack.

A randomised controlled trial of triple antiplatelet therapy (Aspirin, Clopidogrel and Dipyridamole) in the secondary prevention of stroke: safety, tolerability and feasibility (2008)
Journal Article
Sprigg, N., Gray, L. J., England, T. J., Wilmot, M. R., Zhao, L., Sare, G. M., & Bath, P. M. (2008). A randomised controlled trial of triple antiplatelet therapy (Aspirin, Clopidogrel and Dipyridamole) in the secondary prevention of stroke: safety, tolerability and feasibility. PLoS ONE, 3(8),

Background: Aspirin, dipyridamole and clopidogrel are effective in secondary vascular prevention. Combination therapy with three antiplatelet agents might maximise the benefit of antiplatelet treatment in the secondary prevention of ischaemic stroke.... Read More about A randomised controlled trial of triple antiplatelet therapy (Aspirin, Clopidogrel and Dipyridamole) in the secondary prevention of stroke: safety, tolerability and feasibility.

Sex differences in quality of life in stroke survivors. Data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST) (2007)
Journal Article
Gray, L. J., Sprigg, N., Bath, P. M., Boysen, G., De Deyn, P. P., Leys, D., …Ringelstein, B. (2007). Sex differences in quality of life in stroke survivors. Data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST). Stroke, 38, https://doi.org/10.1161/STROKEAHA.107.488304

Introduction: Female sex is predictive of poor functional outcome in stroke, even after correction for prognostic factors. Poor quality of life (QoL) is observed in stroke survivors, with lower scores seen in the most disabled patients. We used data... Read More about Sex differences in quality of life in stroke survivors. Data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST).

Stroke severity, early recovery and outcome are each related with clinical classification of stroke: data from the 'Tinzaparin in Acute Ischaemic Stroke Trial (TAIST) (2007)
Journal Article
Sprigg, N., Gray, L. J., Bath, P. M., Lindenstrom, E., Boysen, G., De Deyn, P. P., …Ringelstein, B. (2007). Stroke severity, early recovery and outcome are each related with clinical classification of stroke: data from the 'Tinzaparin in Acute Ischaemic Stroke Trial (TAIST). Journal of the Neurological Sciences, 254(1-2),

Introduction: Baseline severity and clinical stroke syndrome (Oxford Community Stroke Project, OCSP) classification are predictors of outcome in stroke. We used data from the ‘Tinzaparin in Acute Ischaemic Stroke Trial’ (TAIST) to assess the relation... Read More about Stroke severity, early recovery and outcome are each related with clinical classification of stroke: data from the 'Tinzaparin in Acute Ischaemic Stroke Trial (TAIST).

Amphetamine increases blood pressure and heart rate but has no effect on motor recovery or cerebral haemodynamics in ischaemic stroke: a randomized controlled trial (ISRCTN 36285333) (2007)
Journal Article
Sprigg, N., Willmot, M., Gray, L. J., Sunderland, A., Pomeroy, V., Walker, M., & Bath, P. M. (2007). Amphetamine increases blood pressure and heart rate but has no effect on motor recovery or cerebral haemodynamics in ischaemic stroke: a randomized controlled trial (ISRCTN 36285333). Journal of Human Hypertension, 21(8),

Amphetamine enhances recovery after experimental ischaemia and has shown promise in small clinical trials when combined with motor or sensory stimulation. Amphetamine, a sympathomimetic, might have haemodynamic effects in stroke patients, although li... Read More about Amphetamine increases blood pressure and heart rate but has no effect on motor recovery or cerebral haemodynamics in ischaemic stroke: a randomized controlled trial (ISRCTN 36285333).