Stroke severity, early recovery and outcome are each related with clinical classification of stroke: data from the 'Tinzaparin in Acute Ischaemic Stroke Trial (TAIST)

Sprigg, Nikola; Gray, Laura J.; Bath, Philip M.W.; Lindenstrom, Ewa; Boysen, Gudrun; De Deyn, Peter Paul; Friis, Pal; Leys, Didier; Marttila, Reijo; Olsson, Jan-Edwin; O'Neill, Desmond; Ringelstein, Bernd

Stroke severity, early recovery and outcome are each related with clinical classification of stroke: data from the 'Tinzaparin in Acute Ischaemic Stroke Trial (TAIST)

Sprigg, Nikola; Gray, Laura J.; Bath, Philip M.W.; Lindenstrom, Ewa; Boysen, Gudrun; De Deyn, Peter Paul; Friis, Pal; Leys, Didier; Marttila, Reijo; Olsson, Jan-Edwin; O'Neill, Desmond; Ringelstein, Bernd

Authors

NIKOLA SPRIGG nikola.sprigg@nottingham.ac.uk
Professor of Stroke Medicine

Laura J. Gray

Philip M.W. Bath

Ewa Lindenstrom

Gudrun Boysen

Peter Paul De Deyn

Pal Friis

Didier Leys

Reijo Marttila

Jan-Edwin Olsson

Desmond O'Neill

Bernd Ringelstein

Abstract

Introduction: Baseline severity and clinical stroke syndrome (Oxford Community Stroke Project, OCSP) classification are predictors of outcome in stroke. We used data from the ‘Tinzaparin in Acute Ischaemic Stroke Trial’ (TAIST) to assess the relationship between stroke severity, early recovery, outcome and OCSP syndrome. Methods: TAIST was a randomised controlled trial assessing the safety and efficacy of tinzaparin versus aspirin in 1,484 patients with acute ischaemic stroke. Severity was measured as the Scandinavian Neurological Stroke Scale (SNSS) at baseline and days 4, 7 and 10, and baseline OCSP clinical classification recorded: total anterior circulation infarct (TACI), partial anterior circulation infarct (PACI), lacunar infarct (LACI) and posterior circulation infarction (POCI). Recovery was calculated as change in SNSS from baseline at day 4 and 10. The relationship between stroke syndrome
and SNSS at days 4 and 10, and outcome (modified Rankin scale at 90 days) were assessed.
Results: Stroke severity was significantly different between TACI (most severe) and LACI (mildest) at all four time points (p

Journal Article Type	Article
Publication Date	Mar 15, 2007
Deposit Date	Nov 21, 2007
Publicly Available Date	Nov 21, 2007
Journal	Journal of the Neurological Sciences
Print ISSN	0022-510X
Electronic ISSN	0022-510X
Publisher	Elsevier
Peer Reviewed	Peer Reviewed
Volume	254
Issue	1-2
Keywords	tinzaparin, acute ischaemic Stroke
Public URL	https://nottingham-repository.worktribe.com/output/704028
Publisher URL	http://www.elsevier.com/wps/find/journaldescription.cws_home/506078/description#description