Tranexamic Acid for Spontaneous Intracerebral Hemorrhage: A Randomized Controlled Pilot Trial (ISRCTN50867461)

Sprigg, Nikola; Renton, Cheryl J.; Dineen, Robert A.; Kwong, Yune; Bath, Philip M.W.

Abstract

Background: Spontaneous intracerebral hemorrhage (ICH) can be devastating, particularly if hematoma expansion (HE) occurs. Tranexamic acid (TA), an antifibrinolytic drug, significantly reduced mortality in bleeding patients after trauma in the large CRASH-2 trial. The CRASH-2 ICH substudy found that TA nonsignificantly reduced mortality and dependency in traumatic ICH. The aim of this study was to assess the feasibility of performing a randomized controlled trial of tranexamic acid in spontaneous ICH, ahead of a definitive study.
Methods: We performed a single-center, prospective, randomized (2:1), double-blind, placebo-controlled blinded endpoint trial of TA (intravenous 1 g bolus, 1 g infusion/8 h) in acute (

Citation

Sprigg, N., Renton, C. J., Dineen, R. A., Kwong, Y., & Bath, P. M. (2014). Tranexamic Acid for Spontaneous Intracerebral Hemorrhage: A Randomized Controlled Pilot Trial (ISRCTN50867461). Journal of Stroke and Cerebrovascular Diseases, 23(6), 1312-1318. https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.11.007

• Journal Article Type: Article
• Acceptance Date: Nov 15, 2013
• Online Publication Date: Mar 31, 2014
• Publication Date: 2014-07
• Deposit Date: Oct 19, 2016
• Publicly Available Date: Oct 19, 2016
• Journal: Journal of Stroke and Cerebrovascular Diseases
• Print ISSN: 1052-3057
• Electronic ISSN: 1532-8511
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 23
• Issue: 6
• Pages: 1312-1318
• DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.11.007
• Keywords: acute stroke, intracerebral hemorrhage, tranexamic acid, randomized controlled trials
• Public URL: https://nottingham-repository.worktribe.com/output/724087
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S1052305713004734