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Tranexamic Acid for Spontaneous Intracerebral Hemorrhage: A Randomized Controlled Pilot Trial (ISRCTN50867461)

Sprigg, Nikola; Renton, Cheryl J.; Dineen, Robert A.; Kwong, Yune; Bath, Philip M.W.

Authors

NIKOLA SPRIGG nikola.sprigg@nottingham.ac.uk
Professor of Stroke Medicine

Cheryl J. Renton

Yune Kwong

PHILIP BATH philip.bath@nottingham.ac.uk
Stroke Association Professor of Stroke Medicine



Abstract

Background: Spontaneous intracerebral hemorrhage (ICH) can be devastating, particularly if hematoma expansion (HE) occurs. Tranexamic acid (TA), an antifibrinolytic drug, significantly reduced mortality in bleeding patients after trauma in the large CRASH-2 trial. The CRASH-2 ICH substudy found that TA nonsignificantly reduced mortality and dependency in traumatic ICH. The aim of this study was to assess the feasibility of performing a randomized controlled trial of tranexamic acid in spontaneous ICH, ahead of a definitive study.
Methods: We performed a single-center, prospective, randomized (2:1), double-blind, placebo-controlled blinded endpoint trial of TA (intravenous 1 g bolus, 1 g infusion/8 h) in acute (

Citation

Sprigg, N., Renton, C. J., Dineen, R. A., Kwong, Y., & Bath, P. M. (2014). Tranexamic Acid for Spontaneous Intracerebral Hemorrhage: A Randomized Controlled Pilot Trial (ISRCTN50867461). Journal of Stroke and Cerebrovascular Diseases, 23(6), 1312-1318. https://doi.org/10.1016...rebrovasdis.2013.11.007

Journal Article Type Article
Acceptance Date Nov 15, 2013
Online Publication Date Mar 31, 2014
Publication Date 2014-07
Deposit Date Oct 19, 2016
Publicly Available Date Oct 19, 2016
Journal Journal of Stroke and Cerebrovascular Diseases
Print ISSN 1052-3057
Electronic ISSN 1532-8511
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 23
Issue 6
Pages 1312-1318
DOI https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.11.007
Keywords acute stroke, intracerebral hemorrhage, tranexamic acid, randomized controlled trials
Public URL http://eprints.nottingham.ac.uk/id/eprint/37685
Publisher URL http://www.sciencedirect.com/science/article/pii/S1052305713004734
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

Files

Sprigg J Stroke Cerebrovasc Dis 2014 23 1312 Tranexamic acid for spontaneous intr hemorr.pdf (415 Kb)
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Publisher Licence URL
http://creativecommons.org/licenses/by-nc-nd/4.0/

Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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