Polly Scutt
Baseline characteristics, analysis plan and report on feasibility for the Prevention Of Decline in Cognition After Stroke Trial (PODCAST)
Scutt, Polly; Blackburn, Dan; Krishnan, Kailash; Ballard, Clive; Burns, Alistair; Ford, Gary A.; Mant, Jonathan; Passmore, Peter; Pocock, Stuart; Reckless, John; Sprigg, Nikola; Stewart, Rob; Wardlaw, Joanna M.; Bath, Philip M.W.
Authors
Dan Blackburn
Kailash Krishnan
Clive Ballard
Alistair Burns
Gary A. Ford
Jonathan Mant
Peter Passmore
Stuart Pocock
John Reckless
NIKOLA SPRIGG nikola.sprigg@nottingham.ac.uk
Professor of Stroke Medicine
Rob Stewart
Joanna M. Wardlaw
Philip M.W. Bath
Abstract
Background
A common complication after stroke is development of cognitive impairment and dementia. However, effective strategies for reducing the risk of developing these problems remain undefined. Potential strategies include intensive lowering of blood pressure (BP) and/or lipids. This paper summarises the baseline characteristics, statistical analysis plan and feasibility of a randomised control trial of blood pressure and lipid lowering in patients post-stroke with the primary objective of reducing cognitive impairment and dementia.
Methods
The Prevention Of Decline in Cognition After Stroke Trial (PODCAST) was a multi-centre prospective randomised open-label blinded-endpoint controlled partial-factorial internal pilot trial running in secondary and primary care. Participants without dementia were enrolled 3–7 months post ischaemic stroke or spontaneous intracerebral haemorrhage, and randomised to intensive versus guideline BP lowering (target systolic BP
Citation
Scutt, P., Blackburn, D., Krishnan, K., Ballard, C., Burns, A., Ford, G. A., …Bath, P. M. (2015). Baseline characteristics, analysis plan and report on feasibility for the Prevention Of Decline in Cognition After Stroke Trial (PODCAST). Trials, 16(1), Article 509. https://doi.org/10.1186/s13063-015-1033-2
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 27, 2015 |
Publication Date | Nov 7, 2015 |
Deposit Date | Oct 3, 2016 |
Publicly Available Date | Oct 3, 2016 |
Journal | Trials |
Electronic ISSN | 1745-6215 |
Publisher | Springer Verlag |
Peer Reviewed | Peer Reviewed |
Volume | 16 |
Issue | 1 |
Article Number | 509 |
DOI | https://doi.org/10.1186/s13063-015-1033-2 |
Public URL | https://nottingham-repository.worktribe.com/output/767323 |
Publisher URL | http://trialsjournal.biomedcentral.com/articles/10.1186/s13063-015-1033-2 |
Files
Baseline characteristics analysis plan and report on feasibility for the Prevention Of Decline in Cognition After Stroke Trial (PODCAST).pdf
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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