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Morphological investigation of canine epigastric organs and adjacent structures via computed tomography, ultrasound and anatomical prosection (2021)
Journal Article
Alsafy, M. A., Hanafy, B. G., Rutland, C. S., Karkoura, A. A., Enany, E., & El-gendy, S. A. (2022). Morphological investigation of canine epigastric organs and adjacent structures via computed tomography, ultrasound and anatomical prosection. Morphologie, 106(355), 271-286. https://doi.org/10.1016/j.morpho.2021.08.001

The canine epigastric organs, their locations and visualization of these components are essential for veterinary practice and anatomical research. Despite their importance, conflicts and discrepancies in the published material, to date, still exist,... Read More about Morphological investigation of canine epigastric organs and adjacent structures via computed tomography, ultrasound and anatomical prosection.

Immunohistochemical Characterisation of GLUT1, MMP3 and NRF2 in Osteosarcoma (2021)
Journal Article
Rutland, C. S., Cockcroft, J. M., Lothion-Roy, J., Harris, A. E., Jeyapalan, J. N., Simpson, S., …Mongan, N. P. (2021). Immunohistochemical Characterisation of GLUT1, MMP3 and NRF2 in Osteosarcoma. Frontiers in Veterinary Science, 8, Article 704598. https://doi.org/10.3389/fvets.2021.704598

Osteosarcoma (OSA) is an aggressive bone malignancy. Unlike many other malignancies, OSA outcomes have not improved in recent decades. One challenge to the development of better diagnostic and therapeutic methods for OSA has been the lack of well cha... Read More about Immunohistochemical Characterisation of GLUT1, MMP3 and NRF2 in Osteosarcoma.

A Trifecta of New Insights into Ovine Footrot for Infection Drivers, Immune Response, and Host-Pathogen Interactions (2021)
Journal Article
Blanchard, A. M., Staley, C. E., Shaw, L., Wattegedera, S. R., Baumbach, C., Michler, J. K., …Tötemeyer, S. (2021). A Trifecta of New Insights into Ovine Footrot for Infection Drivers, Immune Response, and Host-Pathogen Interactions. Infection and Immunity, 89(10), Article e00270-21. https://doi.org/10.1128/iai.00270-21

Footrot is a polymicrobial infectious disease in sheep causing severe lameness, leading to one of the industry’s largest welfare problems. The complex etiology of footrot makes in situ or in vitro investigations difficult. Computational methods offer... Read More about A Trifecta of New Insights into Ovine Footrot for Infection Drivers, Immune Response, and Host-Pathogen Interactions.

Proangiogenic Effect of 2A-Peptide Based Multicistronic Recombinant Constructs Encoding VEGF and FGF2 Growth Factors (2021)
Journal Article
Gatina, D. Z., Garanina, E. E., Zhuravleva, M. N., Synbulatova, G. E., Mullakhmetova, A. F., Solovyeva, V. V., …Salafutdinov, I. I. (2021). Proangiogenic Effect of 2A-Peptide Based Multicistronic Recombinant Constructs Encoding VEGF and FGF2 Growth Factors. International Journal of Molecular Sciences, 22(11), Article 5922. https://doi.org/10.3390/ijms22115922

Coronary artery disease remains one of the primary healthcare problems due to the high cost of treatment, increased number of patients, poor clinical outcomes, and lack of effective therapy. Though pharmacological and surgical treatments positively a... Read More about Proangiogenic Effect of 2A-Peptide Based Multicistronic Recombinant Constructs Encoding VEGF and FGF2 Growth Factors.

Diagnosis, Prognosis, Management, Treatment, Research and Advances in Canine Dilated Cardiomyopathy (2021)
Book Chapter
Simpson, S., Kordtomeikel, K., Wong, S., Bennison, S., El-Gendy, S. A., Cobb, M., & Rutland, C. S. (2021). Diagnosis, Prognosis, Management, Treatment, Research and Advances in Canine Dilated Cardiomyopathy. In C. Rutland (Ed.), Canine Medicine : Recent Topics and Advanced Research (1-22). InTech. https://doi.org/10.5772/intechopen.97682

Dilated cardiomyopathy involves enlargement of the ventricular chamber and systolic dysfunction. The reduction in quality of life and increased levels of congestive heart failure, combined with the high diagnosis rate within the canine population, hi... Read More about Diagnosis, Prognosis, Management, Treatment, Research and Advances in Canine Dilated Cardiomyopathy.

A history of lameness and low body condition score is associated with reduced digital cushion volume, measured by magnetic resonance imaging, in dairy cattle (2021)
Journal Article
Wilson, J., Randall, L., Green, M., Rutland, C., Bradley, C., Ferguson, H., …Huxley, J. (2021). A history of lameness and low body condition score is associated with reduced digital cushion volume, measured by magnetic resonance imaging, in dairy cattle. Journal of Dairy Science, https://doi.org/10.3168/jds.2020-19843

Morphology, adipocyte size, and fatty acid analysis of dairy cattle digital cushions, and the effect of body condition score and age (2021)
Journal Article
Newsome, R. F., Mostyn, A., Wilson, J. P., Alibhai, A., Bollard, N., Randall, L., …Rutland, C. S. (2021). Morphology, adipocyte size, and fatty acid analysis of dairy cattle digital cushions, and the effect of body condition score and age. Journal of Dairy Science, 104(5), https://doi.org/10.3168/jds.2020-19388

The digital cushion is an essential part of maintaining a healthy foot, working to dissipate foot strike and body weight forces and lameness from claw horn disruption lesions. Despite the importance of the digital cushion, little is known about the b... Read More about Morphology, adipocyte size, and fatty acid analysis of dairy cattle digital cushions, and the effect of body condition score and age.

Skeleton Growth in Guinea Pigs and Humans (2021)
Journal Article
Skinner, Z., Clark, N., Rutland, S., Dawkins, A., & Rutland, C. S. (2021). Skeleton Growth in Guinea Pigs and Humans. Frontiers for Young Minds, 9,

Every animal has a skeleton made up of many different bones. Bones are vital. Without bones we would not be able to move, protect our internal organs, store important minerals, or even make some cell types! When we are young, in addition to growing,... Read More about Skeleton Growth in Guinea Pigs and Humans.

Current Trends in Cancer Immunotherapy (2020)
Journal Article
Filin, I. Y., Solovyeva, V. V., Kitaeva, K. V., Rutland, C. S., & Rizvanov, A. A. (2020). Current Trends in Cancer Immunotherapy. Biomedicines, 8(12), 1-36. https://doi.org/10.3390/biomedicines8120621

The search for an effective drug to treat oncological diseases, which have become the main scourge of mankind, has generated a lot of methods for studying this affliction. It has also become a serious challenge for scientists and clinicians who have... Read More about Current Trends in Cancer Immunotherapy.

The Importance of Anatomy (2020)
Journal Article
Stanford, K., Rutland, S., Sturrock, C. J., & Rutland, C. S. (2020). The Importance of Anatomy. Frontiers for Young Minds, 8, Article 546763. https://doi.org/10.3389/frym.2020.546763

Anatomy is the knowledge about the structure of the bodies of animals and people. This includes information about blood vessels, organs, the skeleton, and nerves. But have you ever wondered where the anatomical information in science books and websit... Read More about The Importance of Anatomy.

Methods for studying endocytotic pathways of herpesvirus encoded g protein-coupled receptors (2020)
Journal Article
Mavri, M., Spiess, K., Rosenkilde, M. M., Rutland, C. S., Vrecl, M., & Kubale, V. (2020). Methods for studying endocytotic pathways of herpesvirus encoded g protein-coupled receptors. Molecules, 25(23), Article 5710. https://doi.org/10.3390/molecules25235710

Endocytosis is a fundamental process involved in trafficking of various extracellular and transmembrane molecules from the cell surface to its interior. This enables cells to communicate and respond to external environments, maintain cellular homeost... Read More about Methods for studying endocytotic pathways of herpesvirus encoded g protein-coupled receptors.

Extracellular Vesicles: New Perspectives of Regenerative and Reproductive Veterinary Medicine (2020)
Journal Article
Zakirova, E. Y., Aimaletdinov, A. M., Malanyeva, A. G., Rutland, C. S., & Rizvanov, A. A. (2020). Extracellular Vesicles: New Perspectives of Regenerative and Reproductive Veterinary Medicine. Frontiers in Veterinary Science, 7, Article 594044. https://doi.org/10.3389/fvets.2020.594044

Extracellular vesicles are released by all cell types including stem cells. Stem cell-released extracellular vesicles have therapeutic effects similar to those of their parent cells and have regenerative effects in tissues. They also have an immunomo... Read More about Extracellular Vesicles: New Perspectives of Regenerative and Reproductive Veterinary Medicine.

Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D2 Dopamine Receptor (D2-R) Isoforms (2020)
Journal Article
Blagotinšek Cokan, K., Mavri, M., Rutland, C. S., Glišić, S., Senćanski, M., Vrecl, M., & Kubale, V. (2020). Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D2 Dopamine Receptor (D2-R) Isoforms. Biomolecules, 10(10), Article 1355. https://doi.org/10.3390/biom10101355

The type 2 dopamine receptor D2 (D2-R), member of the G protein-coupled receptor (GPCR) superfamily, exists in two isoforms, short (D2S-R) and long (D2L-R). They differ by an additional 29 amino acids (AA) in the third cytoplasmic loop (ICL3) of the... Read More about Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D2 Dopamine Receptor (D2-R) Isoforms.

Promising Applications of Tumor Spheroids and Organoids for Personalized Medicine (2020)
Journal Article
Gilazieva, Z., Ponomarev, A., Rutland, C., Rizvanov, A., & Solovyeva, V. (2020). Promising Applications of Tumor Spheroids and Organoids for Personalized Medicine. Cancers, 12(10), Article 2727. https://doi.org/10.3390/cancers12102727

One of the promising directions in personalized medicine is the use of three-dimensional (3D) tumor models such as spheroids and organoids. Spheroids and organoids are three-dimensional cultures of tumor cells that can be obtained from patient tissue... Read More about Promising Applications of Tumor Spheroids and Organoids for Personalized Medicine.

Molecular characterisation of canine osteosarcoma in high risk breeds (2020)
Journal Article
Simpson, S., Dunning, M., de Brot, S., Alibhai, A., Bailey, C., Woodcock, C. L., …Rutland, C. S. (2020). Molecular characterisation of canine osteosarcoma in high risk breeds. Cancers, 12(9), Article 2405. https://doi.org/10.3390/cancers12092405

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Dogs develop osteosarcoma (OSA) and the disease process closely resembles that of human OSA. OSA has a poor prognosis in both species and disease-free intervals and cure rates have not improve... Read More about Molecular characterisation of canine osteosarcoma in high risk breeds.

Can Toothache Cause Heartbreak? (2020)
Journal Article
Clark, N., Skinner, Z., & Rutland, C. S. (2020). Can Toothache Cause Heartbreak?. Frontiers for Young Minds, 8, https://doi.org/10.3389/frym.2020.00087

Poor mouth care and heart disease are two major health concerns worldwide. Both conditions occur in humans and in many mammals, including our pets. “Periodontal” is the word used to refer to structures surrounding the teeth, including the gums and bo... Read More about Can Toothache Cause Heartbreak?.

Gene Therapy as a Modern Method of Treating Naturally Occurring Tendinitis and Desmitis in Horses (2020)
Book Chapter
Zakirova, E., Milomir, K., Zhuravleva, M., Rutland, C., & Rizvanov, A. (2020). Gene Therapy as a Modern Method of Treating Naturally Occurring Tendinitis and Desmitis in Horses. In C. Rutland, & A. Rizvanov (Eds.), Equine science. InTech. https://doi.org/10.5772/intechopen.92352

Tendon and ligament injuries have always been complex to treat, with recovery often taking many months, if successful at all. This chapter looks at recent work undertaken using regenerative medicine, specifically gene therapy and the advances that ha... Read More about Gene Therapy as a Modern Method of Treating Naturally Occurring Tendinitis and Desmitis in Horses.