Skip to main content

Research Repository

Advanced Search

Gene Therapy as a Modern Method of Treating Naturally Occurring Tendinitis and Desmitis in Horses

Zakirova, Elena; Milomir, Kovac; Zhuravleva, Margarita; Rutland, Catrin; Rizvanov, Albert

Authors

Elena Zakirova

Kovac Milomir

Margarita Zhuravleva

Albert Rizvanov



Contributors

Albert Rizvanov
Editor

Abstract

Tendon and ligament injuries have always been complex to treat, with recovery often taking many months, if successful at all. This chapter looks at recent work undertaken using regenerative medicine, specifically gene therapy and the advances that have been made in equine therapy. It looks at the process from plasmid construction, in vitro testing through to trialing the equine-specific plasmid construct in horses with superficial digital flexor tendon (tendinitis) and suspensory ligament branch injuries. It also looks at the rationale for utilizing vascular endothelial growth factor (VEGF164) and a basic fibroblast growth factor (FGF2) for these trials and the cellular effects and potential mechanisms of actions.

Citation

Zakirova, E., Milomir, K., Zhuravleva, M., Rutland, C., & Rizvanov, A. (2020). Gene Therapy as a Modern Method of Treating Naturally Occurring Tendinitis and Desmitis in Horses. In C. Rutland, & A. Rizvanov (Eds.), Equine science. InTech. https://doi.org/10.5772/intechopen.92352

Acceptance Date Jun 19, 2020
Online Publication Date Jun 19, 2020
Publication Date 2020
Deposit Date Jun 22, 2020
Publicly Available Date Jun 22, 2020
Publisher InTech
Book Title Equine science
ISBN 978183962316-
DOI https://doi.org/10.5772/intechopen.92352
Keywords Horse, gene therapy, tissue regeneration, superficial digital flexor tendon, tendon injuries, suspensory ligament
Public URL https://nottingham-repository.worktribe.com/output/4701305
Publisher URL https://www.intechopen.com/online-first/gene-therapy-as-a-modern-method-of-treating-naturally-occurring-tendinitis-and-desmitis-in-horses

Files





You might also like



Downloadable Citations