All Outputs (4605)

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels (2018)
Journal Article

Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). I... Read More about Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.

Species distribution modelling: contrasting presence-only models with plot abundance data (2018)
Journal Article

Species distribution models (SDMs) are widely used in ecology and conservation. Presence-only SDMs such as MaxEnt frequently use natural history collections (NHCs) as occurrence data, given their huge numbers and accessibility. NHCs are often spatial... Read More about Species distribution modelling: contrasting presence-only models with plot abundance data.

Development and validation of self-reported line drawings of the modified Beighton score for the assessment of generalised joint hypermobility (2018)
Journal Article

Background: The impracticalities and comparative expense of carrying out a clinical assessment is an obstacle in many large epidemiological studies. The purpose of this study was to develop and validate a series of electronic self-reported line drawi... Read More about Development and validation of self-reported line drawings of the modified Beighton score for the assessment of generalised joint hypermobility.

The impact of de-tiering in the UK's large value payment system (2018)
Journal Article

Large-value payment systems (LVPS) often have a tiered structure where only a limited number of banks have direct access to these systems and every other institution accesses the system through agency arrangements with the direct participants. As suc... Read More about The impact of de-tiering in the UK's large value payment system.

The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors (2018)
Journal Article

The dopamine D2 and D3 receptors (D2R and D3R) are important targets for antipsychotics and for the treatment of drug abuse. SB269652, a bitopic ligand that simultaneously binds both the orthosteric binding site (OBS) and a secondary binding pocket (... Read More about The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors.

Identifying rail asset maintenance processes: a human-centric and sensemaking approach (2018)
Journal Article

Efficient asset maintenance is key for delivering services such as transport. Current rail maintenance processes have been mostly reactive with a recent shift towards exploring proactive modes. The introduction of new ubiquitous technologies and adva... Read More about Identifying rail asset maintenance processes: a human-centric and sensemaking approach.

Progress towards a methodology for high throughput 3D reconstruction of soot nanoparticles via electron tomography (2018)
Journal Article

The aim of this work is to make progress towards the development of 3D reconstruction as a legitimate alternative to traditional 2D characterisation of soot. Time constraints are the greatest opposition to its implementation, as currently reconstruct... Read More about Progress towards a methodology for high throughput 3D reconstruction of soot nanoparticles via electron tomography.

An iterated local search algorithm for the team orienteering problem with variable profits (2018)
Journal Article

The orienteering problem (OP) is a routing problem that has numerous applications in various domains such as logistics and tourism. The objective is to determine a subset of vertices to visit for a vehicle so that the total collected score is maximiz... Read More about An iterated local search algorithm for the team orienteering problem with variable profits.

Voltage- and light-controlled spin properties of a two-dimensional hole gas in p-type GaAs/AlAs resonant tunneling diodes (2018)
Journal Article

We have investigated the spin properties of a two-dimensional hole gas (2DHG) formed at the contact layer of a p-type GaAs/AlAs resonant tunneling diode (RTD). We have measured the polarized-resolved photoluminescence of the RTD as a function of bias... Read More about Voltage- and light-controlled spin properties of a two-dimensional hole gas in p-type GaAs/AlAs resonant tunneling diodes.

Adaptive wild bootstrap tests for a unit root with non-stationary volatility (2018)
Journal Article

© 2017 The Authors. The Econometrics Journal published by John Wiley & Sons Ltd on behalf of Royal Economic Society. Recent research has emphasized that permanent changes in the innovation variance (caused by structural shifts or an integrated vola... Read More about Adaptive wild bootstrap tests for a unit root with non-stationary volatility.

Variation and constraints in hybrid genome formation (2018)
Journal Article

Hybridization is an important source of variation; it transfers adaptive genetic variation across species boundaries and generates new species. Yet, the limits to viable hybrid genome formation are poorly understood. Here we investigated to what exte... Read More about Variation and constraints in hybrid genome formation.

The peptide PnPP-19, a spider toxin derivative, activates ?-opioid receptors and modulates calcium channels (2018)
Journal Article

The synthetic peptide PnPP-19 comprehends 19 amino acid residues and it represents part of the primary structure of the toxin ?-CNTX-Pn1c (PnTx2-6), isolated from the venom of the spider Phoneutria nigriventer. Behavioural tests suggest that PnPP-19... Read More about The peptide PnPP-19, a spider toxin derivative, activates ?-opioid receptors and modulates calcium channels.

Label-free, high resolution, multi-modal light microscopy for discrimination of live stem cell differentiation status (2018)
Journal Article

A label-free microscopy method for assessing the differentiation status of stem cells is presented with potential application for characterization of therapeutic stem cell populations. The microscopy system is capable of characterizing live cells bas... Read More about Label-free, high resolution, multi-modal light microscopy for discrimination of live stem cell differentiation status.

Protection of regulatory autonomy and investor obligations: latest trends in investment treaty design (2018)
Journal Article

Learning position controls for hybrid step motors: from current-fed to full-order models (2018)
Journal Article

The experimental comparison of two different global learning position controls (namely, ‘adaptive learning’ and ‘repetitive learning’ controls) for hybrid step motors performing repetitive tasks has been recently presented in the literature. Related... Read More about Learning position controls for hybrid step motors: from current-fed to full-order models.

Excitation energies from Görling–Levy perturbation theory along the range-separated adiabatic connection (2018)
Journal Article

A Görling–Levy (GL)-based perturbation theory along the range-separated adiabatic connection is assessed for the calculation of electronic excitation energies. In comparison with the Rayleigh–Schrödinger (RS)-based perturbation theory this GL-based p... Read More about Excitation energies from Görling–Levy perturbation theory along the range-separated adiabatic connection.

Human management and landscape changes at Palaikastro (Eastern Crete) from the Late Neolithic to the Early Minoan period (2018)
Journal Article

On the east Mediterranean island of Crete, a hierarchical society centred on large palatial complexes emerges during the Bronze Age. The economic basis for this significant social change has long been debated, particularly concerning the role of oliv... Read More about Human management and landscape changes at Palaikastro (Eastern Crete) from the Late Neolithic to the Early Minoan period.

An electrochemical system for the study of trans-plasma membrane electron transport in whole eukaryotic cells (2018)
Journal Article

The development of new assays to study trans-plasma membrane electron transport (tPMET) in eukaryotic systems is paramount for a number reasons, which include the further understanding of the underlying biology which can then potentially be applied t... Read More about An electrochemical system for the study of trans-plasma membrane electron transport in whole eukaryotic cells.

Functional modelling in evolvable assembly systems (2018)
Conference Proceeding

The design and reconfiguration of adaptive production systems is a key driver in modern advanced manufacturing. We summarise the use of an ap-proach from the field of functional modelling to capture the function, behaviour, and structure of a system.... Read More about Functional modelling in evolvable assembly systems.

Doxycycline compared to prednisolone therapy for patients with bullous pemphigoid: cost-effectiveness analysis of the BLISTER trial (2018)
Journal Article

Background: Bullous pemphigoid (BP) is an autoimmune blistering skin disorder associated with significant morbidity and mortality. Doxycycline and prednisolone to treat bullous pemphigoid were compared within a randomised controlled trial (RCT).... Read More about Doxycycline compared to prednisolone therapy for patients with bullous pemphigoid: cost-effectiveness analysis of the BLISTER trial.