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All Outputs (36)

Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation (2023)
Working Paper
Abhishek, A., Grainge, M. J., Card, T., Williams, H. C., Taal, M. W., Aithal, G. P., …Riley, R. D. Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation

Background Sulfasalazine induced cytopenia, nephrotoxicity, and hepatotoxicity is uncommon during long-term treatment. Some guidelines recommend three monthly monitoring blood-tests indefinitely while others recommend stopping monitoring after one ye... Read More about Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation.

Exposure to Climate Change Information on Affect and Pro‐Environmental Behavioural Intentions: A Randomised Controlled Trial (2023)
Working Paper
Greaves, S., Harvey, C., & Kotera, Y. (2023). Exposure to Climate Change Information on Affect and Pro‐Environmental Behavioural Intentions: A Randomised Controlled Trial

The study aimed to investigate the effect of climate change exposure on affect and pro-environmental behavioural intentions in a randomised controlled trial. An online survey was completed by 100 adult participants and included measures of affect and... Read More about Exposure to Climate Change Information on Affect and Pro‐Environmental Behavioural Intentions: A Randomised Controlled Trial.

A time-resolved Förster resonance energy transfer assay to investigate inhibitor binding to ABCG2 (2023)
Working Paper
Mitchell-White, J. I., Briggs, D. A., Mistry, S. J., Mbiwan, H. A., Kellam, B., Holliday, N. D., …Kerr, I. D. A time-resolved Förster resonance energy transfer assay to investigate inhibitor binding to ABCG2

The human ATP-binding cassette (ABC) transporter, ABCG2 is responsible for multidrug resistance in some tumours. Detailed knowledge of its activity is crucial for understanding drug transport and resistance in cancer, and has implications for wider p... Read More about A time-resolved Förster resonance energy transfer assay to investigate inhibitor binding to ABCG2.

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases (2023)
Working Paper
Huang, J., Shek, N., Choy, A., Lang, C., Miller, B., Tal-Singer, R., …Brown, M. Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Aging is a major driving force for many diseases but the relationship between age, aging processes and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related... Read More about Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.

Beyond the Bedside: Protocol for a scoping review exploring the experiences of non-practicing healthcare professionals within health professions education (2023)
Working Paper
Church, H. R., Brown, M. E., Govender, L., & Clark, D. Beyond the Bedside: Protocol for a scoping review exploring the experiences of non-practicing healthcare professionals within health professions education

Background: The number of healthcare professionals leaving clinical practice and transitioning to alternative careers in health professions education is increasing. Among these non-practicing healthcare professionals, concerns have been reported rega... Read More about Beyond the Bedside: Protocol for a scoping review exploring the experiences of non-practicing healthcare professionals within health professions education.

A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data (2023)
Working Paper
Zuffa, S., Schmid, R., Bauermeister, A., Gomes, P. W. P., Caraballo-Rodriguez, A. M., Abiead, Y. E., …Dorrestein, P. C. A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data

MicrobeMASST, a taxonomically-informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can search known... Read More about A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data.

Examining the Use of Autonomous Systems for Home Health Support using a Smart Mirror (2023)
Working Paper
Dowthwaite, L., Reyez Cruz, G., Pena, A. R., Pepper, C., Jäger, N., Barnard, P., …Benford, S. Examining the Use of Autonomous Systems for Home Health Support using a Smart Mirror

The home is becoming a key location for healthcare delivery, including the use of technology driven by autonomous systems (AS) to monitor and support healthcare plans. Using the example of a smart mirror, this paper describes the outcomes of focus gr... Read More about Examining the Use of Autonomous Systems for Home Health Support using a Smart Mirror.

PDI-functionalised glass beads: efficient, metal-free heterogeneous photocatalysts suitable for flow photochemistry (2023)
Working Paper
Ali, H., Ahmed, I., Robertson, K., & Lanterna, A. PDI-functionalised glass beads: efficient, metal-free heterogeneous photocatalysts suitable for flow photochemistry

Perylene diimides (PDI) have an extraordinary ability to activate both energy and electron transfer process upon light excitation, however, their extremely low solubility has hindered their wide use as photocatalysts. Here, we show a series of suppor... Read More about PDI-functionalised glass beads: efficient, metal-free heterogeneous photocatalysts suitable for flow photochemistry.

UK Flockdown: Exploring the knowledge, attitudes and practices of backyard poultry keepers surrounding Highly Pathogenic Avian Influenza (HPAI) (2023)
Working Paper
McClaughlin, E., Elliott, S., Jewitt, S., Smallman-Raynor, M., Dunham, S., Parnell, T., …Tarlinton, R. UK Flockdown: Exploring the knowledge, attitudes and practices of backyard poultry keepers surrounding Highly Pathogenic Avian Influenza (HPAI)

The scale of the current outbreak of highly pathogenic avian influenza (HPAI) due to the A/H5N1 virus in the United Kingdom is unprecedented. In addition to its economic impact on the commercial poultry sector, the disease has devastated wild bird co... Read More about UK Flockdown: Exploring the knowledge, attitudes and practices of backyard poultry keepers surrounding Highly Pathogenic Avian Influenza (HPAI).

Generative AI: Implications and Applications for Education (2023)
Working Paper
Olga, A., Saini, A., Zapata, G., Searsmith, D., Cope, B., Kalantzis, M., …Polyxeni Kastania, N. Generative AI: Implications and Applications for Education

The launch of ChatGPT in November 2022 precipitated a panic among some educators while prompting qualified enthusiasm from others. Under the umbrella term Generative AI, ChatGPT is an example of a range of technologies for the delivery of computer-ge... Read More about Generative AI: Implications and Applications for Education.

The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study (2023)
Working Paper
Swiderski, M., Vinogradova, Y., Knaggs, R., Harman, K., Harwood, R., Prasad, V., …Gran, S. (0000). The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study

Introduction Bullous pemphigoid (BP) is a serious skin disease that results in large painful blisters developing over the body and occurs most commonly in older people (over 70 years). Despite several comorbidities such as stroke and a threefold inc... Read More about The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study.

Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID) (2023)
Working Paper
Elneima, O., McAuley, H. J. C., Leavy, O. C., Chalmers, J. D., Horsley, A., Ho, L., …on behalf of the PHOSP-COVID Collaborative Group. Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID)

PHOSP-COVID is a national UK multi-centre cohort study of patients who were hospitalised for COVID-19 and subsequently discharged. PHOSP-COVID was established to investigate the medium- and long-term sequelae of severe COVID-19 requiring hospitali... Read More about Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID).

Assessing the residual benefit of soil-applied zinc on grain zinc nutritional quality of maize grown under contrasting soil types in Malawi. (2023)
Working Paper
Botoman, L., Chimungu, J. G., Bailey, E. H., Munthali, M. W., Ander, E. L., Mossa, A., …Nalivata, P. C. Assessing the residual benefit of soil-applied zinc on grain zinc nutritional quality of maize grown under contrasting soil types in Malawi

A proper understanding of the residual value of zinc (Zn) is necessary for sustainable biofortification of food crops. This study aimed to establish the extent to which application of Zn at the national rate, plus two experimentally elevated rates, i... Read More about Assessing the residual benefit of soil-applied zinc on grain zinc nutritional quality of maize grown under contrasting soil types in Malawi..

Ukraine and the Netherlands v. Russia, Merits Amicus Curiae Brief Submitted on behalf of the Human Rights Law Centre of the University of Nottingham (2023)
Working Paper
Milanovic, M., & Shah, S. Ukraine and the Netherlands v. Russia, Merits Amicus Curiae Brief Submitted on behalf of the Human Rights Law Centre of the University of Nottingham

This is an amicus curiae brief at the merits stage in the case of Ukraine and the Netherlands v. Russia (nos 8019/16, 43800/14, 28525/20 and 11055/22) before the European Court of Human Rights, filed on behalf of the Human Rights Law Centre at the Un... Read More about Ukraine and the Netherlands v. Russia, Merits Amicus Curiae Brief Submitted on behalf of the Human Rights Law Centre of the University of Nottingham.

Genotypic Response of Finger Millet to Zinc and Iron Agronomic Biofortification, Location and Slope Position Towards Yield (2023)
Working Paper
Senbetu, D. T., Gashu, D., Joy, E. M., Lark, M. R., Bailey, E. H., Wilson, L., …Broadley, M. R. Genotypic Response of Finger Millet to Zinc and Iron Agronomic Biofortification, Location and Slope Position Towards Yield

The present study aimed to investigate influence of genotypic differences to zinc and iron agronomic biofortification responses among yield of finger millet. A field experiment was conducted over two seasons in farmers’ fields in Ethiopia (2019, 2020... Read More about Genotypic Response of Finger Millet to Zinc and Iron Agronomic Biofortification, Location and Slope Position Towards Yield.

‘We went from understanding, to disappointment, resentment and often grief all in the space of 6 months’ A qualitative study of the stories of family carers of care home residents during COVID-19 pandemic in 2020 (2023)
Working Paper
Hinsliff-Smith, K., Griffiths, S., Padley, W., De Vries, K., & Brown, J. (0000). ‘We went from understanding, to disappointment, resentment and often grief all in the space of 6 months’ A qualitative study of the stories of family carers of care home residents during COVID-19 pandemic in 2020

When the WHO announced a global pandemic in response to COVID-19, individual countries reacted in a similar way with care homes closing their doors to visits, including visits from family members. The UK was no different, initially they closed to pro... Read More about ‘We went from understanding, to disappointment, resentment and often grief all in the space of 6 months’ A qualitative study of the stories of family carers of care home residents during COVID-19 pandemic in 2020.

SteatoSITE: an Integrated Gene-to-Outcome Data Commons for Precision Medicine Research in NAFLD (2023)
Working Paper
Fallowfield, J., Kendall, T., Jimenez-Ramos, M., Turner, F., Ramachandran, P., Minnier, J., …Guha, I. SteatoSITE: an Integrated Gene-to-Outcome Data Commons for Precision Medicine Research in NAFLD

Nonalcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease worldwide and a growing healthcare burden. The pathobiology of NAFLD is complex, disease progression is variable and unpredictable, and there are no qualified pr... Read More about SteatoSITE: an Integrated Gene-to-Outcome Data Commons for Precision Medicine Research in NAFLD.

Competitive plasticity to reduce the energetic costs of learning (2023)
Working Paper
van Rossum, M. C. Competitive plasticity to reduce the energetic costs of learning

The brain is not only constrained by energy needed to fuel computation, but it is also constrained by energy needed to form memories. Experiments have shown that learning simple conditioning tasks already carries a significant metabolic cost. Yet, le... Read More about Competitive plasticity to reduce the energetic costs of learning.