All Outputs (3811)

Discovery of novel quinoline–chalcone derivatives as potent antitumor agents with microtubule polymerization inhibitory activity (2018)
Journal Article

© 2018 American Chemical Society. A series of novel quinoline-chalcone derivatives were designed, synthesized, and evaluated for their antiproliferative activity. Among them, compound 24d exhibited the most potent activity with IC 50 values ranging... Read More about Discovery of novel quinoline–chalcone derivatives as potent antitumor agents with microtubule polymerization inhibitory activity.

Probabilistic-based assessment of existing steel-concrete composite bridges : application to Sousa River Bridge (2018)
Journal Article

This paper presents a framework to assess the safety of existing structures, combining deterministic model identification and reliability assessment techniques, considering both load-test and complementary laboratory test results. Firstly, the propos... Read More about Probabilistic-based assessment of existing steel-concrete composite bridges : application to Sousa River Bridge.

“I’m a medic”: a web-based, social capital approach to health careers (2018)
Journal Article

Widening access to medicine in U.K. requires outreach that engages schools in remote areas, schools with below average attainment, and schools serving disadvantaged communities in order to develop a more representative profession and meet serious wor... Read More about “I’m a medic”: a web-based, social capital approach to health careers.

Cyclic and Post-cycling Anchor Response in Geocell-Reinforced Sand (2018)
Journal Article

Plate anchors are commonly used to resist static, cyclic and monotonic after cyclic-loading uplift loads. Under cyclic loading, progressive sudden failure may occur, characterized by accumulated displacement – even under loads significantly less than... Read More about Cyclic and Post-cycling Anchor Response in Geocell-Reinforced Sand.

Thinking outside of the box II: disrupting the cognitive map (2018)
Journal Article

A number of influential spatial learning theories posit that organisms encode a viewpoint independent (i.e. allocentric) representation of the global boundary shape of their environment in order to support spatial reorientation and place learning. In... Read More about Thinking outside of the box II: disrupting the cognitive map.

The relationship between patients’ illness beliefs and recovery after stroke (2018)
Journal Article

The Common Sense Model (CSM) is a useful framework for understanding mood and treatment adherence amongst survivors in the acute phase of stroke. CSM stroke studies have thus far focused on the single outcomes, mood and medication adherence, neglecti... Read More about The relationship between patients’ illness beliefs and recovery after stroke.

Determination of geochronology and sedimentation rates of shallow lakes in the middle Yangtze reaches using 210 Pb, 137 Cs and spheroidal carbonaceous particles (2018)
Journal Article

Accurate chronologies for recent sediments of shallow lakes in the Yangtze floodplain are critical to calibrate proxy records for reconstructing environmental changes during the past century. This study presents the results of detailed 210Pb analysis... Read More about Determination of geochronology and sedimentation rates of shallow lakes in the middle Yangtze reaches using 210 Pb, 137 Cs and spheroidal carbonaceous particles.

Cooperation between protein kinase A (PKA) and high osmolarity glycerol reponse (HOG) pathways is affecting cell wall carbohydrate mobilization in Aspergillus fumigatus (2018)
Journal Article

Aspergillus fumigatus mitogen-activated protein kinases (MAPKs) are involved in maintaining the normal morphology of the cell wall and providing resistance against cell wall-damaging agents. Upon cell wall stress, cell wall-related sugars need to be... Read More about Cooperation between protein kinase A (PKA) and high osmolarity glycerol reponse (HOG) pathways is affecting cell wall carbohydrate mobilization in Aspergillus fumigatus.

The pupil dilation response during speech perception in dark and light: the involvement of the parasympathetic nervous system in listening effort (2018)
Journal Article

Recently, the measurement of the pupil dilation response has been applied in many studies to assess listening effort. Meanwhile, the mechanisms underlying this response are still largely unknown. We present the results of a method that separates the... Read More about The pupil dilation response during speech perception in dark and light: the involvement of the parasympathetic nervous system in listening effort.

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study (2018)
Journal Article

Background Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel genetic variants associated with moderate-to-severe asthma, see whether previously identified genetic variants for all types of asthma contribut... Read More about Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.

Collaborative Virtual Environment to Facilitate Game Design Evaluation with Children with ASC (2018)
Journal Article

© 2018 Taylor & Francis Group, LLC. Involvement of children with autism spectrum conditions (ASC) in the design of new educational technology is becoming more prevalent. Despite potential barriers due to communication and ideation difficulties for... Read More about Collaborative Virtual Environment to Facilitate Game Design Evaluation with Children with ASC.

Varying magnesium concentration elicits changes in inflammatory response in human umbilical vein endothelial cells (HUVECs) (2018)
Journal Article

The aims of this study were to determine whether low concentrations of magnesium in vitro exacerbated the human umbilical vein endothelial cell (HUVEC) response to inflammatory challenge, and whether expression of the nuclear factor kappa-light-chain... Read More about Varying magnesium concentration elicits changes in inflammatory response in human umbilical vein endothelial cells (HUVECs).

The Ambiguities of Belief and Belonging: Catholicism and the Church of the East in the Sixteenth Century (2018)
Journal Article

This article considers the emergence of the Chaldaean (East Syrian Catholic) Church in the 1550s, a topic of considerable relevance for scholars of eastern Christianity and of Counter-Reformation Catholicism alike. The Chaldaeans seem to present a pa... Read More about The Ambiguities of Belief and Belonging: Catholicism and the Church of the East in the Sixteenth Century.

The pharmacy care plan service: Evaluation and estimate of cost-effectiveness (2018)
Journal Article

Background: The UK Community Pharmacy Future group developed the Pharmacy Care Plan (PCP) service with a focus on patient activation, goal setting and therapy management. Objective: To estimate the effectiveness and cost-effectiveness of the PCP... Read More about The pharmacy care plan service: Evaluation and estimate of cost-effectiveness.

The use of decellularised animal tissue to study disseminating cancer cells (2018)
Journal Article

Since the establishment of cell culture, common practice has been to grow adherent cells in 2D monolayers. Although cells behave completely differently when grown under these artificial conditions, the ease of 2D culturing has meant that this practic... Read More about The use of decellularised animal tissue to study disseminating cancer cells.

Quantitative RT-PCR assays for identification and typing of the Equine encephalosis virus (2018)
Journal Article

© 2018, Sociedade Brasileira de Microbiologia. Equine encephalosis (EE) is an acute, arthropod-borne, noncontagious, febrile disease of equids. The clinical signs of EE are similar to milder forms of African horse sickness (AHS) and the two diseases... Read More about Quantitative RT-PCR assays for identification and typing of the Equine encephalosis virus.

Synthesis, molecular properties prediction and biological evaluation of indole-vinyl sulfone derivatives as novel tubulin polymerization inhibitors targeting the colchicine binding site (2018)
Journal Article

Twenty-two novel indole-vinyl sulfone derivatives were designed, synthesized and evaluated as tubulin polymerization inhibitors. The physicochemical and drug-likeness properties of all target compounds were predicted by Osiris calculations. All compo... Read More about Synthesis, molecular properties prediction and biological evaluation of indole-vinyl sulfone derivatives as novel tubulin polymerization inhibitors targeting the colchicine binding site.

AutoSpec: fast automated spectral extraction software for IFU data cubes (2018)
Journal Article

With the ever-growing popularity of integral field unit (IFU) spectroscopy, countless observations are being performed over multiple object systems such as blank fields and galaxy clusters. With this, an increasing amount of time is being spent extra... Read More about AutoSpec: fast automated spectral extraction software for IFU data cubes.

Dynamical criticality in open systems: nonperturbative physics, microscopic origin, and direct observation (2018)
Journal Article

Driven diffusive systems may undergo phase transitions to sustain atypical values of the current. This leads in some cases to symmetry-broken space-time trajectories which enhance the probability of such fluctuations. Here, we shed light on both the... Read More about Dynamical criticality in open systems: nonperturbative physics, microscopic origin, and direct observation.

“The good guys are doing it anyway”: the accommodation of environmental concern among English and Welsh farmers (2018)
Journal Article

Farmers today are increasingly facing pressure from policy and market forces to improve their environmental performance. Yet – despite widespread recognition of the negative externalities of agriculture on a national and global scale – many farmers w... Read More about “The good guys are doing it anyway”: the accommodation of environmental concern among English and Welsh farmers.