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Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women (2015)
Journal Article

Context and objective: We evaluated the predictive value of serum cartilage oligomeric matrix protein (sCOMP) levels over 20 years on the development of radiographic (RKOA) and painful knee osteoarthritis (KOA) in a longitudinal cohort of middle-aged... Read More about Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women.

Manipulation of Conditions during Wort Collection in Production-Scale Fermentations to Regulate Volatile Ester Synthesis as an Aid to Product Matching for Multisite Brewing (2015)
Journal Article

© 2015 American Society of Brewing Chemists, Inc. Volatile esters are amongst the most important yeast-derived flavoractive compounds produced during brewery fermentation. Dissolved oxygen concentration has long been recognized as an effector for the... Read More about Manipulation of Conditions during Wort Collection in Production-Scale Fermentations to Regulate Volatile Ester Synthesis as an Aid to Product Matching for Multisite Brewing.

Experimental analysis of ethanol dual-fuel combustion in a heavy-duty diesel engine: An optimisation at low load (2015)
Journal Article

Conventional diesel combustion produces harmful exhaust emissions which adversely affect the air quality if not controlled by in-cylinder measures and exhaust aftertreatment systems. Dual-fuel combustion can potentially reduce the formation of nitrog... Read More about Experimental analysis of ethanol dual-fuel combustion in a heavy-duty diesel engine: An optimisation at low load.

ELF5 drives lung metastasis in luminal breast cancer through recruitment of Gr1+ CD11b+ myeloid-derived suppressor cells (2015)
Journal Article

During pregnancy, the ETS transcription factor ELF5 establishes the milk-secreting alveolar cell lineage by driving a cell fate decision of the mammary luminal progenitor cell. In breast cancer, ELF5 is a key transcriptional determinant of tumor subt... Read More about ELF5 drives lung metastasis in luminal breast cancer through recruitment of Gr1+ CD11b+ myeloid-derived suppressor cells.

Pharmacological analysis and structure determination of 7-methylcyanopindolol–bound b1-adrenergic receptor (2015)
Journal Article

Comparisons between structures of the b1-adrenergic receptor (AR) bound to either agonists, partial agonists, or weak partial agonists led to the proposal that rotamer changes of Ser5.46, coupled to a contraction of the binding pocket, are sufficient... Read More about Pharmacological analysis and structure determination of 7-methylcyanopindolol–bound b1-adrenergic receptor.

Development, testing and reporting of mobile apps for psycho-social interventions: lessons from the pharmaceuticals (2015)
Journal Article

The mobile Health offers great potential for delivery of Psycho-social Interventions. So far, the researchers have focused mainly on efficacy, and to some extent feasibility of Psycho-social Interventions. Poor reporting of development and initial te... Read More about Development, testing and reporting of mobile apps for psycho-social interventions: lessons from the pharmaceuticals.

4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor (2015)
Journal Article

Positive allosteric modulators (PAMs) of the M1 muscarinic acetylcholine receptor (M1 mAChR) are a promising strategy for the treatment of the cognitive deficits associated with diseases including Alzheimer’s and schizophrenia. Herein, we report the... Read More about 4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor.

H-ATLAS/GAMA: quantifying the morphological evolution of the galaxy population using cosmic calorimetry (2015)
Journal Article

Using results from the Herschel Astrophysical Terrahertz Large-Area Survey (H-ATLAS) and the Galaxy and Mass Assembly (GAMA) project, we show that, for galaxy masses above ≃ 108 M⊙, 51 per cent of the stellar mass-density in the local Universe is in... Read More about H-ATLAS/GAMA: quantifying the morphological evolution of the galaxy population using cosmic calorimetry.