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Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women

Kluzek, Stefan; Bay-Jensen, Anne-Christine; Judge, Andrew; Karsdal, Morten A.; Shorthose, Matthew; Spector, Tim; Hart, Deborah; Newton, Julia L.; Arden, Nigel K.

Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women Thumbnail


Authors

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STEFAN KLUZEK Stefan.Kluzek@nottingham.ac.uk
Clinical Associate Professor

Anne-Christine Bay-Jensen

Andrew Judge

Morten A. Karsdal

Matthew Shorthose

Tim Spector

Deborah Hart

Julia L. Newton

Nigel K. Arden



Abstract

Context and objective: We evaluated the predictive value of serum cartilage oligomeric matrix protein (sCOMP) levels over 20 years on the development of radiographic (RKOA) and painful knee osteoarthritis (KOA) in a longitudinal cohort of middle-aged women.

Materials and methods: Five hundred and ninety-three women with no baseline KOA underwent 5-year knee radiographs over 20-years and were asked about knee pain a month before each assessment. A repeated measures logistic regression model was used where the outcomes were recorded at 5, 10, 15 and 20-years follow-up.

Results: The highest quartile of sCOMP was associated with increased risk of RKOA with overall OR of 1.97 (95% CI: 1.33–2.91) over 20 years when compared with the lowest sCOMP quartile. The association with painful KOA was similar and also independent, but only when the fourth and third sCOMP quartiles were compared.

Discussion and conclusion: This study demonstrates that sCOMP levels are predictive of subsequent structural changes and incidence of painful KOA, independently of age and BMI.

Citation

Kluzek, S., Bay-Jensen, A., Judge, A., Karsdal, M. A., Shorthose, M., Spector, T., …Arden, N. K. (2015). Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women. Biomarkers, 20(8), 557-564. https://doi.org/10.3109/1354750x.2015.1105498

Journal Article Type Article
Acceptance Date Jul 7, 2015
Online Publication Date Feb 5, 2016
Publication Date 2015
Deposit Date May 20, 2020
Publicly Available Date Mar 28, 2024
Journal Biomarkers
Print ISSN 1354-750X
Publisher Taylor & Francis Open
Peer Reviewed Peer Reviewed
Volume 20
Issue 8
Pages 557-564
DOI https://doi.org/10.3109/1354750x.2015.1105498
Public URL https://nottingham-repository.worktribe.com/output/4471222
Publisher URL https://www.tandfonline.com/doi/full/10.3109/1354750X.2015.1105498

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