Efficacy of progesterone supplementation during early pregnancy in cows: a meta-analysis

Yan, Leyan; Robinson, Robert S.; Shi, Zhendan; Mann, George E.

Abstract

Progesterone is a critical hormone during early pregnancy in the cow. As a result, a number of studies have investigated the effects of progesterone supplementation on pregnancy rates. In this study, a meta-analysis using a univariate binary random effects model was carried out on 84 specific treatments reported in 53 publications involving control (n = 9905) and progesterone-treated (n = 9135) cows. Although the results of individual studies showed wide variations (?40% to +50% point changes), progesterone treatment resulted in an overall increase in pregnancy rate odds ratio (OR = 1.12; P < 0.01). Improvements in pregnancy rate were only observed in cows treated at natural estrus (OR = 1.41, P < 0.01) and not following synchronization of estrus or ovulation. Although treatment between Days 3 to 7 postinsemination was beneficial (OR = 1.15; P < 0.01), treatment earlier or later than this was not. Progesterone supplementation was beneficial in cows of lower fertility (

Citation

Yan, L., Robinson, R. S., Shi, Z., & Mann, G. E. (2016). Efficacy of progesterone supplementation during early pregnancy in cows: a meta-analysis. Theriogenology, 85(8), Article 1390-1398.e1. https://doi.org/10.1016/j.theriogenology.2015.12.027

• Journal Article Type: Article
• Acceptance Date: Dec 23, 2015
• Online Publication Date: Dec 31, 2015
• Publication Date: May 31, 2016
• Deposit Date: Nov 18, 2016
• Publicly Available Date: Nov 18, 2016
• Journal: Theriogenology
• Print ISSN: 0093-691X
• Electronic ISSN: 1879-3231
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 85
• Issue: 8
• Article Number: 1390-1398.e1
• DOI: https://doi.org/10.1016/j.theriogenology.2015.12.027
• Keywords: Progesterone supplementation; Cow; Pregnancy; Meta-analysis
• Public URL: https://nottingham-repository.worktribe.com/output/787905
• Publisher URL: http://dx.doi.org/10.1016/j.theriogenology.2015.12.027