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All Outputs (9)

What characteristics of primary care and patients are associated with early death in patients with lung cancer in the UK? (2014)
Journal Article
O'Dowd, E. L., McKeever, T. M., Baldwin, D. R., Anwar, S., Powell, H. A., Gibson, J. E., …Hubbard, R. B. (2015). What characteristics of primary care and patients are associated with early death in patients with lung cancer in the UK?. Thorax, 70(2), https://doi.org/10.1136/thoraxjnl-2014-205692

Background: The UK has poor lung cancer survival rates and high early mortality, compared to other countries. We aimed to identify factors associated with early death, and features of primary care that might contribute to late diagnosis. Methods: Al... Read More about What characteristics of primary care and patients are associated with early death in patients with lung cancer in the UK?.

Increasing global mortality from idiopathic pulmonary fibrosis in the twenty-first century (2014)
Journal Article
Hutchinson, J. P., McKeever, T. M., Fogarty, A. W., Navaratnam, V., & Hubbard, R. B. (2014). Increasing global mortality from idiopathic pulmonary fibrosis in the twenty-first century. Annals of the American Thoracic Society, 11(8), https://doi.org/10.1513/AnnalsATS.201404-145OC

Rationale: Recent evidence from the United Kingdom suggests that the number of deaths from idiopathic pulmonary fibrosis is increasing, although comparable international data are limited. Objectives: We aimed to collate death certification data f... Read More about Increasing global mortality from idiopathic pulmonary fibrosis in the twenty-first century.

The impact of the ‘hub and spoke’ model of care for lung cancer and equitable access to surgery (2014)
Journal Article
Khakwani, A., Rich, A. L., Powell, H. A., Tata, L. J., Stanley, R. A., Baldwin, D. R., …Hubbard, R. B. (2014). The impact of the ‘hub and spoke’ model of care for lung cancer and equitable access to surgery. Thorax, 70(2), https://doi.org/10.1136/thoraxjnl-2014-205841

Objectives: To determine the influence of where a patient is first seen (either surgical or non-surgical centre) and patient features on having surgery for non-small cell lung cancer (NSCLC). Design: Cross-sectional study from individual patients... Read More about The impact of the ‘hub and spoke’ model of care for lung cancer and equitable access to surgery.

First trimester exposure to anxiolytic and hypnotic drugs and the risks of major congenital anomalies: a United Kingdom population-based cohort study (2014)
Journal Article
Ban, L., West, J., Gibson, J. E., Fiaschi, L., Sokal, R., Doyle, P., …Tata, L. J. (2014). First trimester exposure to anxiolytic and hypnotic drugs and the risks of major congenital anomalies: a United Kingdom population-based cohort study. PLoS ONE, 9(6), Article e100996. https://doi.org/10.1371/journal.pone.0100996

BACKGROUND: Despite their widespread use the effects of taking benzodiazepines and non-benzodiazepine hypnotics during pregnancy on the risk of major congenital anomaly (MCA) are uncertain. The objectives were to estimate absolute and relative risks... Read More about First trimester exposure to anxiolytic and hypnotic drugs and the risks of major congenital anomalies: a United Kingdom population-based cohort study.

Maternal depression, antidepressant prescriptions, and congenital anomaly risk in offspring: a population-based cohort study (2014)
Journal Article
Ban, L., Gibson, J. E., West, J., Fiaschi, L., Sokal, R., Smeeth, L., …Tata, L. J. (in press). Maternal depression, antidepressant prescriptions, and congenital anomaly risk in offspring: a population-based cohort study. BJOG: An International Journal of Obstetrics and Gynaecology, 121(12), https://doi.org/10.1111/1471-0528.12682

OBJECTIVE: To estimate risks of major congenital anomaly (MCA) among children of mothers prescribed antidepressants during early pregnancy or diagnosed with depression but without antidepressant prescriptions. DESIGN: Population-based cohort study.... Read More about Maternal depression, antidepressant prescriptions, and congenital anomaly risk in offspring: a population-based cohort study.

Small-Cell Lung Cancer in England: Trends in Survival and Chemotherapy Using the National Lung Cancer Audit (2014)
Journal Article
Khakwani, A., Rich, A. L., Tata, L. J., Powell, H. A., Stanley, R. A., Baldwin, D. R., & Hubbard, R. B. (2014). Small-Cell Lung Cancer in England: Trends in Survival and Chemotherapy Using the National Lung Cancer Audit. PLoS ONE, 9(2), Article e89426. https://doi.org/10.1371/journal.pone.0089426

Background The purpose of this study was to identify trends in survival and chemotherapy use for individuals with small-cell lung cancer (SCLC) in England using the National Lung Cancer Audit (NLCA). Methods We used data from the NLCA database... Read More about Small-Cell Lung Cancer in England: Trends in Survival and Chemotherapy Using the National Lung Cancer Audit.

Signalling Paediatric Side Effects using an Ensemble of Simple Study Designs (2014)
Journal Article
Reps, J., M. Garibaldi, J., Aickelin, U., Soria, D., E. Gibson, J., & B. Hubbard, R. (2014). Signalling Paediatric Side Effects using an Ensemble of Simple Study Designs. Drug Safety, 37(3), 163-170. https://doi.org/10.1007/s40264-014-0137-z

Background: Children are frequently prescribed medication `o-label', meaning there has not been sucient testing of the medication to determine its safety or eectiveness. The main reason this safety knowledge is lacking is due to ethical restrictions... Read More about Signalling Paediatric Side Effects using an Ensemble of Simple Study Designs.

Treatment decisions and survival for people with small-cell lung cancer (2014)
Journal Article
Powell, H., Tata, L., Baldwin, D., Potter, V., Stanley, R., Khakwani, A., & Hubbard, R. (in press). Treatment decisions and survival for people with small-cell lung cancer. British Journal of Cancer, 110(4), https://doi.org/10.1038/bjc.2013.812

Background: Chemotherapy improves survival for many patients with SCLC, and hence it is important to understand variations in practice and outcomes for this treatment strategy. Methods: We used the National Lung Cancer Audit and Hospital Episodes... Read More about Treatment decisions and survival for people with small-cell lung cancer.