Increasing global mortality from idiopathic pulmonary fibrosis in the twenty-first century

Hutchinson, John P.; McKeever, Tricia M.; Fogarty, Andrew W.; Navaratnam, Vidya; Hubbard, Richard B.

Abstract

Rationale: Recent evidence from the United Kingdom suggests that the number of deaths from idiopathic pulmonary fibrosis is increasing, although comparable international data are limited.

Objectives: We aimed to collate death certification data from multiple countries to determine global trends in mortality from idiopathic pulmonary fibrosis.

Methods: Data were obtained from the national statistics agencies of countries with relevant mortality records. Age-standardised mortality rates were calculated, and Poisson regression modelling was used to calculate rate ratios. Meta-analysis was used to calculate an overall estimate of mortality change over time.

Measurements and Main Results: Ten countries provided mortality data on pulmonary fibrosis over a period from 1999 to 2012. Age-standardised mortality ranged between 4 and 10 per 100,000 population for the most recent years of data, being lowest in Sweden (4.68 per 100,000), Spain (5.38 per 100,000) and New Zealand (5.55 per 100,000), and highest in the UK (9.84 per 100,000 in England and Wales, 10.71 per 100,000 in Scotland) and Japan (10.26 per 100,000). Positive associations with male sex and increasing age were consistently observed across all countries. There was an overall 2-3% annual increase in mortality depending on codes used for classification – for broad codes, overall rate ratio 1.03 (95% confidence intervals 1.02-1.04, p

Citation

Hutchinson, J. P., McKeever, T. M., Fogarty, A. W., Navaratnam, V., & Hubbard, R. B. (2014). Increasing global mortality from idiopathic pulmonary fibrosis in the twenty-first century. Annals of the American Thoracic Society, 11(8), https://doi.org/10.1513/AnnalsATS.201404-145OC

• Journal Article Type: Article
• Publication Date: Oct 1, 2014
• Deposit Date: Feb 12, 2016
• Publicly Available Date: Feb 12, 2016
• Journal: Annals of the American Thoracic Society
• Print ISSN: 2329-6933
• Electronic ISSN: 2325-6621
• Publisher: American Thoracic Society
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 8
• DOI: https://doi.org/10.1513/AnnalsATS.201404-145OC
• Keywords: idiopathic pulmonary fibrosis, epidemiology, mortality rates
• Public URL: https://nottingham-repository.worktribe.com/output/994284
• Publisher URL: http://www.atsjournals.org/doi/abs/10.1513/AnnalsATS.201404-145OC#.Vr3cq2fcvcs
• Additional Information: Originally Published in: John P. Hutchinson, Tricia M. McKeever, Andrew W. Fogarty, Vidya Navaratnam, and Richard B. Hubbard "Increasing Global Mortality from Idiopathic Pulmonary Fibrosis in the Twenty-First Century", Annals of the American Thoracic Society, Vol. 11, No. 8 (2014), pp. 1176-1185. DOI: 10.1513/AnnalsATS.201404-145OC ; Copyright © 2015 by the American Thoracic Society ; The final publication is available at http://www.atsjournals.org/doi/abs/10.1513/AnnalsATS.201404-145OC#.Vr3cq2fcvcs.