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Increasing global mortality from idiopathic pulmonary fibrosis in the twenty-first century

Hutchinson, John P.; McKeever, Tricia M.; Fogarty, Andrew W.; Navaratnam, Vidya; Hubbard, Richard B.

Authors

John P. Hutchinson john.hutchinson@nottingham.ac.uk

TRICIA MCKEEVER tricia.mckeever@nottingham.ac.uk
Professor of Epidemiology and Medical Statistics

ANDREW FOGARTY andrew.fogarty@nottingham.ac.uk
Clinical Associate Professor & Reader in Clinical Epidemiology

Vidya Navaratnam vidya.navaratnam@nottingham.ac.uk

RICHARD HUBBARD richard.hubbard@nottingham.ac.uk
Blf/Gsk Professor of Epidemiological Resp Research



Abstract

Rationale: Recent evidence from the United Kingdom suggests that the number of deaths from idiopathic pulmonary fibrosis is increasing, although comparable international data are limited.

Objectives: We aimed to collate death certification data from multiple countries to determine global trends in mortality from idiopathic pulmonary fibrosis.

Methods: Data were obtained from the national statistics agencies of countries with relevant mortality records. Age-standardised mortality rates were calculated, and Poisson regression modelling was used to calculate rate ratios. Meta-analysis was used to calculate an overall estimate of mortality change over time.

Measurements and Main Results: Ten countries provided mortality data on pulmonary fibrosis over a period from 1999 to 2012. Age-standardised mortality ranged between 4 and 10 per 100,000 population for the most recent years of data, being lowest in Sweden (4.68 per 100,000), Spain (5.38 per 100,000) and New Zealand (5.55 per 100,000), and highest in the UK (9.84 per 100,000 in England and Wales, 10.71 per 100,000 in Scotland) and Japan (10.26 per 100,000). Positive associations with male sex and increasing age were consistently observed across all countries. There was an overall 2-3% annual increase in mortality depending on codes used for classification – for broad codes, overall rate ratio 1.03 (95% confidence intervals 1.02-1.04, p

Citation

Hutchinson, J. P., McKeever, T. M., Fogarty, A. W., Navaratnam, V., & Hubbard, R. B. (2014). Increasing global mortality from idiopathic pulmonary fibrosis in the twenty-first century. Annals of the American Thoracic Society, 11(8), doi:10.1513/AnnalsATS.201404-145OC

Journal Article Type Article
Publication Date Oct 1, 2014
Deposit Date Feb 12, 2016
Publicly Available Date Feb 12, 2016
Journal Annals of the American Thoracic Society
Print ISSN 2329-6933
Electronic ISSN 2325-6621
Publisher American Thoracic Society
Peer Reviewed Peer Reviewed
Volume 11
Issue 8
DOI https://doi.org/10.1513/AnnalsATS.201404-145OC
Keywords idiopathic pulmonary fibrosis, epidemiology, mortality rates
Public URL http://eprints.nottingham.ac.uk/id/eprint/31644
Publisher URL http://www.atsjournals.org/doi/abs/10.1513/AnnalsATS.201404-145OC#.Vr3cq2fcvcs
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information Originally Published in: John P. Hutchinson, Tricia M. McKeever, Andrew W. Fogarty, Vidya Navaratnam, and Richard B. Hubbard "Increasing Global Mortality from Idiopathic Pulmonary Fibrosis in the Twenty-First Century", Annals of the American Thoracic Society, Vol. 11, No. 8 (2014), pp. 1176-1185. DOI: 10.1513/AnnalsATS.201404-145OC
Copyright © 2015 by the American Thoracic Society
The final publication is available at http://www.atsjournals....404-145OC#.Vr3cq2fcvcs.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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