All Outputs (2433)

A potential role for cannabinoid receptors in the therapeutic action of fenofibrate (2014)
Journal Article

Cannabinoids are reported to have actions through peroxisome proliferator-activated receptors (PPARs), which led us to investigate PPAR agonists for activity at the cannabinoid receptors. Radio-ligand binding and functional assays were conducted usin... Read More about A potential role for cannabinoid receptors in the therapeutic action of fenofibrate.

Statistical analysis plan for the ‘Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke’ (TARDIS) trial (2014)
Journal Article

Rationale: Antiplatelet agents such as aspirin, clopidogrel and dipyridamole are effective in reducing the risk of recurrence after a stroke. Importantly, the risk of recurrence is highest immediately after the index event while antiplatelets cause b... Read More about Statistical analysis plan for the ‘Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke’ (TARDIS) trial.

Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging (2014)
Journal Article

© 2014 The Author. The original concept of the ischaemic penumbra suggested imaging of regional cerebral blood flow and metabolism would be required to identify tissue that may benefit from intervention. Amide proton transfer magnetic resonance imagi... Read More about Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging.

Elasto-plastic finite element analysis of titanium metal matrix composite shafts under torsional loading (2014)
Journal Article

Elasto-plastic finite element analyses of titanium metal matrix composite shafts subjected to torsional loading are presented based on a unit cell approach. The analyses cover different volume fractions and different values of the coefficient of fric... Read More about Elasto-plastic finite element analysis of titanium metal matrix composite shafts under torsional loading.

Combining two-directional synthesis and tandem reactions. Part 21: Exploitation of a dimeric macrocycle for chain terminus differentiation and synthesis of an sp3-rich library (2014)
Journal Article

The application of a tandem condensation/cyclisation/[3+2]-cycloaddition/elimination reaction gives an sp3-rich tricyclic pyrazoline scaffold with two ethyl esters in a single step from a simple linear starting material. The successive hydrolysis and... Read More about Combining two-directional synthesis and tandem reactions. Part 21: Exploitation of a dimeric macrocycle for chain terminus differentiation and synthesis of an sp3-rich library.

Selective element fission approach for fast FEM simulation of incremental sheet forming based on dual-mesh system (2014)
Journal Article

Incremental sheet forming (ISF) is a highly versatile and flexible process for producing low batches of sheet metal parts. Although finite element (FE) method is a key approach in the study of material deformation in metal forming processes, the appl... Read More about Selective element fission approach for fast FEM simulation of incremental sheet forming based on dual-mesh system.

Influence of waxes on adhesion properties of bituminous binders (2014)
Journal Article

The benefits at the base of WMA technologies are well established in the literature. They include the reduction in the energy consumption during the production of mixtures, the reduction in the emissions to the atmosphere in the production plant and... Read More about Influence of waxes on adhesion properties of bituminous binders.

Simulating Thermochromic and Heat Mirror Glazing Systems in Hot and Cold Climates (2014)
Journal Article

This paper investigates the potential energy requirements for heating and cooling when using a thermochromic glazing system on a highly glazed tall office building and comparisons are made with the respective performance of two heat mirror units and... Read More about Simulating Thermochromic and Heat Mirror Glazing Systems in Hot and Cold Climates.

Relative recency influences object-in-context memory (2014)
Journal Article

In two experiments rats received training on an object-in-context (OIC) task, in which they received preexposure to object A in context x, followed by exposure to object B in context y. In a subsequent test both A and B are presented in either contex... Read More about Relative recency influences object-in-context memory.

What have studies of non-industrialized countries told us about the cause of allergic disease? (2014)
Journal Article

The increase in allergic diseases that was observed in countries that had experienced rapid economic growth since the mid-20th century initiated a search for environmental exposures that may explain these phenomena that continues to the present day.... Read More about What have studies of non-industrialized countries told us about the cause of allergic disease?.

A systematic review of strategies used to increase recruitment of people with cancer or organ failure into clinical trials: implications for palliative care research (2014)
Journal Article

Context. The challenges of palliative care clinical trial recruitment are well documented. Objectives. The aim of the study was to review tested strategies to improve recruitment to trials of people with a range of conditions who may access palliati... Read More about A systematic review of strategies used to increase recruitment of people with cancer or organ failure into clinical trials: implications for palliative care research.

Two-dimensional state sum models and spin structures (2014)
Journal Article

The state sum models in two dimensions introduced by Fukuma, Hosono and Kawai are generalised by allowing algebraic data from a non-symmetric Frobenius algebra. Without any further data, this leads to a state sum model on the sphere. When the data is... Read More about Two-dimensional state sum models and spin structures.

Football: spectacularly insignificant or unspectacularly significant? (2014)
Journal Article

Football supporters are often projected as being obsessed, emotionally saturated and intensely involved with their club. This may be true for some, but much of the time, the consumption of football is mundanely incorporated with other routine behavio... Read More about Football: spectacularly insignificant or unspectacularly significant?.

Improvement over time in outcomes for patients undergoing endoscopic therapy for Barrett's oesophagus-related neoplasia: 6-year experience from the first 500 patients treated in the UK patient registry (2014)
Journal Article

Background Barrett's oesophagus (BE) is a pre-malignant condition leading to oesophageal adenocarcinoma (OAC). Treatment of neoplasia at an early stage is desirable. Combined endoscopic mucosal resection (EMR) followed by radiofrequency ablation (RFA... Read More about Improvement over time in outcomes for patients undergoing endoscopic therapy for Barrett's oesophagus-related neoplasia: 6-year experience from the first 500 patients treated in the UK patient registry.

'Partial' competition of heterobivalent ligand binding may be mistaken for allosteric interactions: a comparison of different target interaction models (2014)
Journal Article

© 2014 The British Pharmacological Society. Background and Purpose Non-competitive drugs that confer allosteric modulation of orthosteric ligand binding are of increasing interest as therapeutic agents. Sought-after advantages include a ceiling level... Read More about 'Partial' competition of heterobivalent ligand binding may be mistaken for allosteric interactions: a comparison of different target interaction models.

Adventitious rooting declines with the vegetative to reproductive switch and involves a changed auxin homeostasis (2014)
Journal Article

Adventitious rooting, whereby roots form from non-root tissues, is critical to the forestry and horticultural industries that depend on propagating plants from cuttings. A major problem is that age of the tissue affects the ability of the cutting to... Read More about Adventitious rooting declines with the vegetative to reproductive switch and involves a changed auxin homeostasis.

Chicken and duck myotubes are highly susceptible and permissive to influenza virus infection (2014)
Journal Article

Skeletal muscle, at 30 to 40% of body mass, is the most abundant soft tissue in the body. Besides its primary function in movement and posture, skeletal muscle is a significant innate immune organ with the capacity to produce cytokines and chemokines... Read More about Chicken and duck myotubes are highly susceptible and permissive to influenza virus infection.

Eligibility for and prescription of urate-lowering treatment in patients with incident gout in England (2014)
Journal Article

Gout is caused by urate crystal deposition secondary to persistent hyperuricemia. Current guidelines recommend urate-lowering treatment to prevent crystal deposition and encourage crystal dissolution for patients with more severe gout or concomitant... Read More about Eligibility for and prescription of urate-lowering treatment in patients with incident gout in England.

Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer (2014)
Journal Article

Background The calpains are intracellular cysteine proteases that function in a variety of important cellular functions, including signalling, motility, apoptosis and survival. In breast cancer high calpain-1 and calpain-2 expression has been asso... Read More about Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer.

Simple psoas cross-sectional area measurement is a quick and easy method to assess sarcopenia and predicts major surgical complications (2014)
Journal Article

Aim Radiologically assessed muscle mass has been suggested as a surrogate marker of functional status and frailty and may predict patients at risk of postoperative complications. We hypothesize that sarcopenia negatively impacts on postoperative r... Read More about Simple psoas cross-sectional area measurement is a quick and easy method to assess sarcopenia and predicts major surgical complications.