All Outputs (1157)

The history of African village chickens: an archaeological and molecular perspective (2013)
Journal Article

The history of the introduction and dispersal of village chickens across the African continent is a subject of intense debate and speculation among scholars. Here, we synthesize and summarise the current scientific genetic and nongenetic knowledge in... Read More about The history of African village chickens: an archaeological and molecular perspective.

A new era for studies on cross-Strait relations: introduction (2013)
Journal Article

After more than half a century’s separation, interaction between China and Taiwan has increased and has progressively changed from a politico-economic interaction to a more civic interaction. Scholars working on cross-Strait relations have recently b... Read More about A new era for studies on cross-Strait relations: introduction.

"No time for a solicitor": implications for delays on the take-up of legal advice (2013)
Journal Article

A study of police custody records highlighted variations between police stations both in the take-up of legal advice and also in the average length of time people were held in custody. To further explore unobserved factors which might impact on such... Read More about "No time for a solicitor": implications for delays on the take-up of legal advice.

Charcoal matter with memory: images of movement, time and duration in the animated films of William Kentridge (2013)
Journal Article

Computational fluid dynamics modelling of an entire synchronous generator for improved thermal management (2013)
Journal Article

This study is the first in a series dedicated to investigating the airflow and thermal management of electrical machines. Owing to the temperature dependent resistive losses in the machine's windings, any improvement in cooling provides a direct redu... Read More about Computational fluid dynamics modelling of an entire synchronous generator for improved thermal management.

The balance of care approach to health and social care planning: Lessons from a systematic literature review (2013)
Journal Article

The strategic allocation of resources is one the most difficult tasks facing health and social care decision makers, with multiple organisations delivering complex services to heterogeneous populations. The enduring appeal of the balance of care appr... Read More about The balance of care approach to health and social care planning: Lessons from a systematic literature review.

Tobacco display and brand communication at the point of sale: implications for adolescent smoking behaviour (2013)
Journal Article

Background: In England, point-of-sale (PoS) displays in larger shops were prohibited in April 2012, with an exemption for smaller retailers until 2015. The aim of this study was to examine the association between tobacco displays and brand communicat... Read More about Tobacco display and brand communication at the point of sale: implications for adolescent smoking behaviour.

Formation of the embryonic organizer is restricted by the competitive influences of Fgf signaling and the SoxB1 transcription factors (2013)
Journal Article

The organizer is one of the earliest structures to be established during vertebrate development and is crucial to subsequent patterning of the embryo. We have previously shown that the SoxB1 transcription factor, Sox3, plays a central role as a trans... Read More about Formation of the embryonic organizer is restricted by the competitive influences of Fgf signaling and the SoxB1 transcription factors.

PRAME Is a Golgi-Targeted Protein That Associates with the Elongin BC Complex and Is Upregulated by Interferon-Gamma and Bacterial PAMPs (2013)
Journal Article

Preferentially expressed antigen in melanoma (PRAME) has been described as a cancer-testis antigen and is associated with leukaemias and solid tumours. Here we show that PRAME gene transcription in leukaemic cell lines is rapidly induced by exposure... Read More about PRAME Is a Golgi-Targeted Protein That Associates with the Elongin BC Complex and Is Upregulated by Interferon-Gamma and Bacterial PAMPs.

Licensing under convex costs (2013)
Journal Article

We show that both the outside and inside innovators license a new product (or drastic process innovation) to all potential licensees in the presence of convex costs, which occur under decreasing returns to scale technologies. An implication of our an... Read More about Licensing under convex costs.

The UK clinical aptitude test and clinical course performance at Nottingham: a prospective cohort study (2013)
Journal Article

Background The UK Clinical Aptitude Test (UKCAT) was introduced in 2006 as an additional tool for the selection of medical students. It tests mental ability in four distinct domains (Verbal Reasoning, Quantitative Reasoning, Abstract Reasoning, and... Read More about The UK clinical aptitude test and clinical course performance at Nottingham: a prospective cohort study.

Invasive lobular carcinoma arising in accessory breast tissue (2013)
Journal Article

Background: Lobular carcinoma in accessory breast tissue is a rare occurrence. We present such a case in a 61-year-old woman. Case presentation: A skin nodule in the axillary skin on excision biopsy revealed invasive lobular carcinoma. Conclus... Read More about Invasive lobular carcinoma arising in accessory breast tissue.

Ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibition is synthetically lethal in XRCC1 deficient ovarian cancer cells (2013)
Journal Article

Introduction Ataxia telangiectasia mutated and Rad3 Related (ATR) protein kinase is a key sensor of single-stranded DNA associated with stalled replication forks and repair intermediates generated during DNA repair. XRCC1 is a critical enzyme in sin... Read More about Ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibition is synthetically lethal in XRCC1 deficient ovarian cancer cells.

Storage and release of spermatozoa from the pre-uterine tube reservoir (2013)
Journal Article

In mammals, after coitus a small number of spermatozoa enter the uterine tube and following attachment to uterine tube epithelium are arrested in a non-capacitated state until peri-ovulatory signalling induces their detachment. Whilst awaiting releas... Read More about Storage and release of spermatozoa from the pre-uterine tube reservoir.

On the rapid demise of Lyman-alpha emitters at z>7 due to the increasing incidence of optically thick absorption systems (2013)
Journal Article

A variety of independent observational studies have now reported a significant decline in the fraction of Lyman-break galaxies which exhibit Ly-a emission over the redshift interval z=6-7. In combination with the strong damping wing extending redward... Read More about On the rapid demise of Lyman-alpha emitters at z>7 due to the increasing incidence of optically thick absorption systems.

mRNA Expression Levels in Failing Human Hearts Predict Cellular Electrophysiological Remodeling: A Population-Based Simulation Study (2013)
Journal Article

Differences in mRNA expression levels have been observed in failing versus non-failing human hearts for several membrane channel proteins and accessory subunits. These differences may play a causal role in electrophysiological changes observed in hum... Read More about mRNA Expression Levels in Failing Human Hearts Predict Cellular Electrophysiological Remodeling: A Population-Based Simulation Study.

Hydrodynamic modelling of protein conformation in solution: ELLIPS and HYDRO (2013)
Journal Article

The last three decades has seen some important advances in our ability to represent the conformation of proteins in solution on the basis of hydrodynamic measurements. Advances in theoretical modeling capabilities have been matched by commensurate ad... Read More about Hydrodynamic modelling of protein conformation in solution: ELLIPS and HYDRO.

Allosteric approaches to GPCR drug discovery (2013)
Journal Article

The use of coercive measures in forensic psychiatric care: legal, ethical and practical challenges (2013)
Journal Article

The use of coercive measures, namely restraint, seclusion and involuntary medication, remain controversial methods of practice within forensic psychiatry. Ethical and moral debates surrounding the use of coercive measures are compounded by the need t... Read More about The use of coercive measures in forensic psychiatric care: legal, ethical and practical challenges.

The impacts of climate change on river flow regimes at the global scale (2013)
Journal Article

This paper presents an assessment of the impacts of climate change on a series of indicators of hydrological regimes across the global domain, using a global hydrological model run with climate scenarios constructed using pattern-scaling from 21 CMIP... Read More about The impacts of climate change on river flow regimes at the global scale.