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Hydrodynamic modelling of protein conformation in solution: ELLIPS and HYDRO

Garc�a de la Torre, Jos�; Harding, Stephen E.


Jos� Garc�a de la Torre

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Professor of Applied Biochemistry


The last three decades has seen some important advances in our ability to represent the conformation of proteins in solution on the basis of hydrodynamic measurements. Advances in theoretical modeling capabilities have been matched by commensurate advances in the precision of hydrodynamic measurements. We consider the advances in whole-body (simple ellipsoid-based) modeling—still useful for providing an overall idea of molecular shape, particularly for those systems where only a limited amount of data is available—and outline the ELLIPS suite of algorithms which facilitates the use of this approach. We then focus on bead modeling strategies, particularly the surface or shell–bead approaches and the HYDRO suite of algorithms. We demonstrate how these are providing great insights into complex issues such as the conformation of immunoglobulins and other multi-domain complexes.


García de la Torre, J., & Harding, S. E. (2013). Hydrodynamic modelling of protein conformation in solution: ELLIPS and HYDRO. Biophysical Reviews, 5(2), 195-206.

Journal Article Type Article
Acceptance Date Jan 22, 2013
Online Publication Date Feb 20, 2013
Publication Date Jun 1, 2013
Deposit Date Jan 31, 2019
Publicly Available Date Jan 31, 2019
Journal Biophysical Reviews
Print ISSN 1867-2450
Electronic ISSN 1867-2469
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 5
Issue 2
Pages 195-206
Keywords Biophysics; Molecular Biology; Structural Biology
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