All Outputs (594)

Profiling strugglers in a graduate-entry medicine course at Nottingham: a retrospective case study (2012)
Journal Article

Background 10-15% of students struggle at some point in their medicine course. Risk factors include weaker academic qualifications, male gender, mental illness, UK ethnic minority status, and poor study skills. Recent research on an undergraduate... Read More about Profiling strugglers in a graduate-entry medicine course at Nottingham: a retrospective case study.

The cosmology of the Fab-Four (2012)
Journal Article

We have recently proposed a novel self tuning mechanism to alleviate the famous cosmological constant problem, based on the general scalar tensor theory proposed by Horndeski. The self-tuning model ends up consisting of four geometric terms in the ac... Read More about The cosmology of the Fab-Four.

Click chemistry in carbon nanoreactors (2012)
Journal Article

Copper-nanoparticle catalytic centres anchored at the 5 graphitic step-edges within hollow carbon nanoreactors exhibit superior activity and stability in cycloaddition reactions as compared to catalytic centres outside the nanoreactors. Nanoscale con... Read More about Click chemistry in carbon nanoreactors.

Glucose: an energy currency and structural precursor in articular cartilage and bone with emerging roles as an extracellular signaling molecule and metabolic regulator (2012)
Journal Article

In the skeletal system glucose serves as an essential source of energy for the development, growth, and maintenance of bone and articular cartilage. It is particularly needed for skeletal morphogenesis during embryonic growth and fetal development. G... Read More about Glucose: an energy currency and structural precursor in articular cartilage and bone with emerging roles as an extracellular signaling molecule and metabolic regulator.

An innovative psychometric solar-powered water desalination system (2012)
Journal Article

Important advances have been made in solar water desalination technology but their wide application is restricted by relatively high capital and running costs. Until recently, solar concentrator collectors had usually been employed to distill water i... Read More about An innovative psychometric solar-powered water desalination system.

A comparative study of adhesion of melanoma and breast cancer cells to blood and lymphatic endothelium (2012)
Journal Article

Background: Lymphovascular invasion (LVI) is an important step in the metastatic cascade; tumor cell migration and adhesion to blood and lymphatic vessels is followed by invasion through the vessel wall and subsequent systemic spread. Although prim... Read More about A comparative study of adhesion of melanoma and breast cancer cells to blood and lymphatic endothelium.

Identification of a nonselective cation channel in isolated lens fiber cells that is activated by cell shrinkage (2012)
Journal Article

The initiation of lens cataract has long been associated with the development of a membrane "leak" in lens fiber cells that depolarizes the lens intracellular potential and elevates intracellular Na+ and Ca2+ concentrations. It has been proposed that... Read More about Identification of a nonselective cation channel in isolated lens fiber cells that is activated by cell shrinkage.

The “Sharp” blade against HIF-mediated metastasis (2012)
Journal Article

Hypoxia-inducible factors (HIFs) control cellular adaptation to oxygen deprivation. Cancer cells engage HIFs to sustain their growth in adverse conditions, thus promoting a cellular reprograming that includes metabolism, proliferation, survival and m... Read More about The “Sharp” blade against HIF-mediated metastasis.

The placental renin-angiotensin system and oxidative stress in pre-eclampsia (2012)
Journal Article

There is an inverse correlation between human birthweight and umbilical venous angiotensin II (AngII) concentrations. Oxidative stress and increased pro-renin receptor (PRR) both enhance the cleavage of angiotensin I from angiotensinogen (AGT). Pre-e... Read More about The placental renin-angiotensin system and oxidative stress in pre-eclampsia.

Enhancing thermal properties of asphalt materials for heat storage and transfer applications (2012)
Journal Article

The paper considers extending the role of asphalt concrete pavements to become solar heat collectors and storage systems. The majority of the construction cost is already procured for such pavements and only marginal additional costs are likely to be... Read More about Enhancing thermal properties of asphalt materials for heat storage and transfer applications.

The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular salmonella typhimurium (2012)
Journal Article

Several species of pathogenic bacteria replicate within an intracellular vacuolar niche. Bacteria that escape into the cytosol are captured by the autophagic pathway and targeted for lysosomal degradation, representing a defense against bacterial exp... Read More about The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular salmonella typhimurium.

Religion and legal spaces: in Gods we Trust; in the Church we Trust, but need to verify (2012)
Journal Article

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons (2012)
Journal Article

Induction of labour versus expectant management for nulliparous women over 35 years of age: a multi-centre prospective, randomised controlled trial (2012)
Journal Article

Background: British women are increasingly delaying childbirth. The proportion giving birth over the age of 35 rose from 12% in 1996 to 20% in 2006. Women over this age are at a higher risk of perinatal death, and antepartum stillbirth accounts for 6... Read More about Induction of labour versus expectant management for nulliparous women over 35 years of age: a multi-centre prospective, randomised controlled trial.

Examining the role of oral contraceptive users as an experimental and/or control group in athletic performance studies (2012)
Journal Article

Background This study was conducted to examine the effect of oral contraceptives on endogenous reproductive hormone levels in order to assess the suitability of oral contraceptive users as experimental and/or control groups in human performance st... Read More about Examining the role of oral contraceptive users as an experimental and/or control group in athletic performance studies.

Second hand smoke exposure and the risk of invasive meningococcal disease in children: systematic review and meta-analysis (2012)
Journal Article

Background Invasive meningococcal disease remains an important cause of serious morbidity and mortality in children and young people. There is a growing body of literature to suggest that exposure to passive smoke may play a role in the developmen... Read More about Second hand smoke exposure and the risk of invasive meningococcal disease in children: systematic review and meta-analysis.

Physical activity and exercise in the treatment of depression (2012)
Journal Article

Compartmentalizing the embryo: Lipids and septate junction mediated barrier function (2012)
Journal Article

Lipid phosphate phosphatases (LPPs) are a class of enzymes that can dephosphorylate a number of lysophopholipids in vitro. Analysis of knockouts of LPP family members has demonstrated striking but diverse developmental roles for these enzymes. LPP3 i... Read More about Compartmentalizing the embryo: Lipids and septate junction mediated barrier function.

Labor market effects of unemployment insurance design (2012)
Journal Article

With the emergence of the Great Recession unemployment insurance (UI) is once again at the heart of the policy debate. In this paper, we focus on the recent theoretical and empirical evidence on the labor market effects of UI design. We provide an ov... Read More about Labor market effects of unemployment insurance design.

Mapping the way forward: education for sustainability in architecture and urban design (2012)
Journal Article

Given the growing relevance of the sustainability agenda to the professions of the built environment, one way to ensure that its mandates are effectively integrated in architecture and urban design is to revisit the role that education, particularly... Read More about Mapping the way forward: education for sustainability in architecture and urban design.