Compartmentalizing the embryo: Lipids and septate junction mediated barrier function

Ile, Kristina E.; Renault, Andrew D.

Abstract

Lipid phosphate phosphatases (LPPs) are a class of enzymes that can dephosphorylate a number of lysophopholipids in vitro. Analysis of knockouts of LPP family members has demonstrated striking but diverse developmental roles for these enzymes. LPP3 is required for mouse vascular development while the Drosophila LPPs Wunen (Wun) and Wunen2 (Wun2) are required during embryogenesis for germ cell migration and survival. In a recent publication we examined if these fly LPPs have further developmental roles and found that Wun is required for proper tracheal formation. In particular we highlight a role for Wun in septate junction mediated barrier function in the tracheal system. In this paper we discuss further the possible mechanisms by which LPPs may influence barrier activity. © 2013 Landes Bioscience.

Citation

Ile, K. E., & Renault, A. D. (2013). Compartmentalizing the embryo: Lipids and septate junction mediated barrier function. Fly, 7(1), 18-22. https://doi.org/10.4161/fly.22938

• Journal Article Type: Article
• Acceptance Date: Nov 16, 2012
• Online Publication Date: Dec 6, 2012
• Publication Date: Jan 1, 2013
• Deposit Date: Aug 3, 2022
• Publicly Available Date: Aug 5, 2022
• Journal: Fly
• Print ISSN: 1933-6934
• Electronic ISSN: 1933-6942
• Publisher: Taylor and Francis
• Peer Reviewed: Peer Reviewed
• Volume: 7
• Issue: 1
• Pages: 18-22
• DOI: https://doi.org/10.4161/fly.22938
• Public URL: https://nottingham-repository.worktribe.com/output/3176265
• Publisher URL: https://www.tandfonline.com/doi/full/10.4161/fly.22938