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Drosophila heart cell movement to the midline occurs through both cell autonomous migration and dorsal closure

Haack, Timm; Schneider, Matthias; Schwendele, Bernd; Renault, Andrew D.

Authors

Timm Haack

Matthias Schneider

Bernd Schwendele

Andrew D. Renault



Abstract

The Drosophila heart is a linear organ formed by the movement of bilaterally specified progenitor cells to the midline and adherence of contralateral heart cells. This movement occurs through the attachment of heart cells to the overlying ectoderm which is undergoing dorsal closure. Therefore heart cells are thought to move to the midline passively. Through live imaging experiments and analysis of mutants that affect the speed of dorsal closure we show that heart cells in Drosophila are autonomously migratory and part of their movement to the midline is independent of the ectoderm. This means that heart formation in flies is more similar to that in vertebrates than previously thought. We also show that defects in dorsal closure can result in failure of the amnioserosa to properly degenerate, which can physically hinder joining of contralateral heart cells leading to a broken heart phenotype.

Journal Article Type Article
Publication Date Dec 15, 2014
Journal Developmental Biology
Print ISSN 0012-1606
Electronic ISSN 0012-1606
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 396
Issue 2
APA6 Citation Haack, T., Schneider, M., Schwendele, B., & Renault, A. D. (2014). Drosophila heart cell movement to the midline occurs through both cell autonomous migration and dorsal closure. Developmental Biology, 396(2), https://doi.org/10.1016/j.ydbio.2014.08.033
DOI https://doi.org/10.1016/j.ydbio.2014.08.033
Keywords Dorsal vessel; Heart; Drosophila; wunen; Amnioserosa; Dorsal closure; Organogenesis
Publisher URL http://dx.doi.org/10.1016/j.ydbio.2014.08.033
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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