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Drosophila heart cell movement to the midline occurs through both cell autonomous migration and dorsal closure

Haack, Timm; Schneider, Matthias; Schwendele, Bernd; Renault, Andrew D.

Authors

Timm Haack

Matthias Schneider

Bernd Schwendele

Andrew D. Renault



Abstract

The Drosophila heart is a linear organ formed by the movement of bilaterally specified progenitor cells to the midline and adherence of contralateral heart cells. This movement occurs through the attachment of heart cells to the overlying ectoderm which is undergoing dorsal closure. Therefore heart cells are thought to move to the midline passively. Through live imaging experiments and analysis of mutants that affect the speed of dorsal closure we show that heart cells in Drosophila are autonomously migratory and part of their movement to the midline is independent of the ectoderm. This means that heart formation in flies is more similar to that in vertebrates than previously thought. We also show that defects in dorsal closure can result in failure of the amnioserosa to properly degenerate, which can physically hinder joining of contralateral heart cells leading to a broken heart phenotype.

Citation

Haack, T., Schneider, M., Schwendele, B., & Renault, A. D. (2014). Drosophila heart cell movement to the midline occurs through both cell autonomous migration and dorsal closure. Developmental Biology, 396(2), https://doi.org/10.1016/j.ydbio.2014.08.033

Journal Article Type Article
Acceptance Date Aug 30, 2014
Online Publication Date Sep 16, 2014
Publication Date Dec 15, 2014
Deposit Date Jun 15, 2016
Publicly Available Date Jun 15, 2016
Journal Developmental Biology
Print ISSN 0012-1606
Electronic ISSN 0012-1606
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 396
Issue 2
DOI https://doi.org/10.1016/j.ydbio.2014.08.033
Keywords Dorsal vessel; Heart; Drosophila; wunen; Amnioserosa; Dorsal closure; Organogenesis
Public URL http://eprints.nottingham.ac.uk/id/eprint/34077
Publisher URL http://dx.doi.org/10.1016/j.ydbio.2014.08.033
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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