All Outputs (408)

The benefits of quantifying climate model uncertainty in climate change impacts assessment: An example with heat-related mortality change estimates (2011)
Journal Article

The majority of climate change impacts assessments account for climate change uncertainty by adopting the scenario-based approach. This typically involves assessing the impacts for a small number of emissions scenarios but neglecting the role of clim... Read More about The benefits of quantifying climate model uncertainty in climate change impacts assessment: An example with heat-related mortality change estimates.

The genetics of pre-eclampsia and other hypertensive disorders of pregnancy (2011)
Journal Article

Hypertension is the most frequent medical complication occurring during pregnancy. In this chapter, we aim to address the genetic contribution to these disorders, with specific focus on preeclampsia. The pathogenic mechanisms underlying pre-eclampsia... Read More about The genetics of pre-eclampsia and other hypertensive disorders of pregnancy.

A "non-parametric" version of the naive Bayes classifier (2011)
Journal Article

Many algorithms have been proposed for the machine learning task of classication. One of the simplest methods, the naive Bayes classifyer, has often been found to give good performance despite the fact that its underlying assumptions (of independence... Read More about A "non-parametric" version of the naive Bayes classifier.

Dynamics of DNA replication in yeast (2011)
Journal Article

We present a mathematical model for the spatial dynamics of DNA replication. Using this model we determine the probability distribution for the time at which each chromosomal position is replicated. From this we show, contrary to previous reports, th... Read More about Dynamics of DNA replication in yeast.

Nonlinear summation really can be used to perform AND operations: reply to May and Zhaoping (2011)
Journal Article

Impulsivity and symptoms of nicotine dependence in a young adult population (2011)
Journal Article

Introduction: Impulsivity is widely regarded as a risk factor for drug dependence. However, its relationship with the symptomatology of nicotine dependence is poorly understood. Methods: To examine the nature of these relationships, we recru... Read More about Impulsivity and symptoms of nicotine dependence in a young adult population.

The importance of antioxidant micronutrients and vitamins in pregnancy (2011)
Journal Article

Pregnancy places increased demands on the mother to provide not only adequate nutrition to support her own health but also to enable the growth and development of the conceptus. A key role of a number of micronutrients and vitamins is their function... Read More about The importance of antioxidant micronutrients and vitamins in pregnancy.

Selenium in reproduction (2011)
Journal Article

Selenium is an essential trace element of importance to human biology and health. Increasing evidence suggests that this mineral plays an important role in normal growth and reproduction in animals and humans, and selenium supplementation is now reco... Read More about Selenium in reproduction.

“Frank Lloyd Oop”: microserfs, modern migration, and the architecture of the nineties (2011)
Journal Article

If the early development of the computing industry in America was marked by a preoccupation with hardware, as companies like UNIVAC, DEC, and IBM filled the nation’s corporate and government offices with mainframes, then a similar pre­occupation has... Read More about “Frank Lloyd Oop”: microserfs, modern migration, and the architecture of the nineties.

Abrasive wear behaviour of conventional and large-particle tungsten carbide-based cermet coatings as a function of abrasive size and type (2011)
Journal Article

Abrasive wear behaviour of materials can be assessed using a wide variety of testing methods, and the relative performance of materials will tend to depend upon the testing procedure employed. In this work, two cermet type coatings have been examined... Read More about Abrasive wear behaviour of conventional and large-particle tungsten carbide-based cermet coatings as a function of abrasive size and type.

Validation of a microsimulation of the port of Dover (2011)
Journal Article

Modelling and simulating the traffic of heavily used but secure environments such as seaports and airports is of increasing importance. Errors made when simulating these environments can have long standing economic, social and environmental implicati... Read More about Validation of a microsimulation of the port of Dover.

SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFN? (2011)
Journal Article

The biologic effects of IFNγ are mediated by the transcription factor STAT1. The activity of STAT1 is inhibited by small ubiquitin-like modifier (SUMO) conjugation. This occurs both directly through decreasing STAT1 tyrosine phosphorylation and indir... Read More about SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFN?.

The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles (2011)
Journal Article

The transcription factor p63 plays pivotal roles in epidermal barrier formation and in embryonic development. The protein structures of TAp63 and ΔNp63α isoforms include a C-terminal steril alpha-motif (SAM) involved in protein–protein interaction. I... Read More about The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles.

Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris (2011)
Journal Article

We have investigated the relationship between the stability and secreted yield of a series of mutational variants of human lysozyme (HuL) in Pichia pastoris. We show that genes directly involved in the unfolded protein response (UPR), ER-associated d... Read More about Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris.

Personality is of central concern to understand health: towards a theoretical model for health psychology (2011)
Journal Article

This paper sets out the case that personality traits are central to health psychology. To achieve this, three aims need to be addressed. First, it is necessary to show that personality influences a broad range of health outcomes and mechanisms. Secon... Read More about Personality is of central concern to understand health: towards a theoretical model for health psychology.

Efficacy, predictability, and safety of wavefront-guided refractive laser treatment: Metaanalysis (2011)
Journal Article

Symposium edition: Public sector reform in Central Asia (2011)
Journal Article

Modelling electricity consumption in office buildings: an agent based approach (2011)
Journal Article

In this paper, we develop an agent-based model which integrates four important elements, i.e. organisational energy management policies/regulations, energy management technologies, electric appliances and equipment, and human behaviour, to simulate t... Read More about Modelling electricity consumption in office buildings: an agent based approach.

Real-time fermions for baryogenesis simulations (2011)
Journal Article

We study how to numerically simulate quantum fermions out of thermal equilibrium, in the context of electroweak baryogenesis. We find that by combining the lattice implementation of Aarts and Smit [1] with the "low cost" fermions of Borsanyi and Hind... Read More about Real-time fermions for baryogenesis simulations.

CHOTs optical transducers (2011)
Journal Article

Laser ultrasonics conventionally use direct absorption in the sample to generate ultrasound and monitor the sample to detect the ultrasound. However, in some circumstances there are significant advantages to using an optical transducer - a device to... Read More about CHOTs optical transducers.