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Curcumin modulates nuclear factor kB (NF-KB)-mediated inflammation in human tenocytes in vitro: Role of the PHOSPHATIDYLINOSITOL 3-KINASE/Akt PATHWAY (2011)
Journal Article
Buhrmann, C., Mobasheri, A., Busch, F., Aldinger, C., Stahlmann, R., Montaseri, A., & Shakibaei, M. (2011). Curcumin modulates nuclear factor kB (NF-KB)-mediated inflammation in human tenocytes in vitro: Role of the PHOSPHATIDYLINOSITOL 3-KINASE/Akt PATHWAY. Journal of Biological Chemistry, 286(32), https://doi.org/10.1074/jbc.M111.256180

Inflammatory processes play essential roles in the pathogenesis of tendinitis and tendinopathy. These events are accompanied by catabolic processes initiated by pro-inflammatory cytokines such as interleukin-1? (IL-1?) and tumor necrosis factor-? (TN... Read More about Curcumin modulates nuclear factor kB (NF-KB)-mediated inflammation in human tenocytes in vitro: Role of the PHOSPHATIDYLINOSITOL 3-KINASE/Akt PATHWAY.

Effects of orally administered Bdellovibrio bacteriovorus on the well-being and Salmonella colonization of young chicks (2011)
Journal Article
Atterbury, R. J., Hobley, L., Till, R., Lambert, C., Capeness, M. J., Lerner, T. R., …Sockett, R. E. (2011). Effects of orally administered Bdellovibrio bacteriovorus on the well-being and Salmonella colonization of young chicks. Applied and Environmental Microbiology, 77(16), https://doi.org/10.1128/AEM.00426-11

Bdellovibrio bacteriovorus is a bacterium which preys upon and kills Gram-negative bacteria, including the zoonotic pathogens Escherichia coli and Salmonella. Bdellovibrio has potential as a biocontrol agent, but no reports of it being tested in livi... Read More about Effects of orally administered Bdellovibrio bacteriovorus on the well-being and Salmonella colonization of young chicks.

High throughput proteomic analysis of the secretome in an explant model of articular cartilage inflammation (2011)
Journal Article
Clutterbuck, A. L., Smith, J. R., Allaway, D., Harris, P., Liddell, S., & Mobasheri, A. (2011). High throughput proteomic analysis of the secretome in an explant model of articular cartilage inflammation. Journal of Proteomics, 74(5), https://doi.org/10.1016/j.jprot.2011.02.017

This study employed a targeted high-throughput proteomic approach to identify the major proteins present in the secretome of articular cartilage. Explants from equine metacarpophalangeal joints were incubated alone or with interleukin-1beta (IL-1?, 1... Read More about High throughput proteomic analysis of the secretome in an explant model of articular cartilage inflammation.

PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1 (2011)
Journal Article
Foxler, D. E., James, V., Shelton, S. J., de A. Vallim, T. Q., Shaw, P. E., & Sharp, T. V. (2011). PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1. FEBS Letters, 585(7), 1089-1096. https://doi.org/10.1016/j.febslet.2011.03.013

LIMD1 is a tumour suppressor gene (TSG) down regulated in ?80% of lung cancers with loss also demonstrated in breast and head and neck squamous cell carcinomas. LIMD1 is also a candidate TSG in childhood acute lymphoblastic leukaemia. Mechanistically... Read More about PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1.

A comparison of broad-spectrum and narrow-spectrum dry cow therapy used alone and in combination with a teat sealant (2011)
Journal Article
Bradley, A. J., Breen, J., Payne, B., & Green, M. J. (2011). A comparison of broad-spectrum and narrow-spectrum dry cow therapy used alone and in combination with a teat sealant. Journal of Dairy Science, 94(2), https://doi.org/10.3168/jds.2010-3192

The dry period is a critical time in the lactation cycle, offering the optimum time for cure of existing intramammary infection (IMI), while also encompassing the periods of highest susceptibility to new intramammary infection. Until recent years, in... Read More about A comparison of broad-spectrum and narrow-spectrum dry cow therapy used alone and in combination with a teat sealant.

Veterinary students' usage and perception of video teaching resources (2011)
Journal Article
Roshier, A. L., Foster, N., & Jones, M. A. (2011). Veterinary students' usage and perception of video teaching resources. BMC Medical Education, 11(Januar), Article 13. https://doi.org/10.1186/1472-6920-11-1

Background: The purpose of our study was to use a student-centred approach to develop an online video learning resource (called 'Moo Tube') at the School of Veterinary Medicine and Science, University of Nottingham, UK and also to provide guidance fo... Read More about Veterinary students' usage and perception of video teaching resources.

Association between somatic cell count and serial locomotion score assessments in UK dairy cows (2011)
Journal Article
Archer, S. C., Madouasse, A., Green, M. J., & Huxley, J. (2011). Association between somatic cell count and serial locomotion score assessments in UK dairy cows. Journal of Dairy Science, 94(9), https://doi.org/10.3168/jds.2011-4276

This research investigated the effect of lameness, measured by locomotion score (LS) on the somatic cell count (SCC) of UK dairy cows. The data set consisted of 11,141 records of SCC and LS collected monthly on 12 occasions from 1,397 cows kept on 7... Read More about Association between somatic cell count and serial locomotion score assessments in UK dairy cows.

Maximising graduate status in pre-registration nursing programmes: Utilising problem based learning (2010)
Journal Article
McGarry, J., Aubeeluck, A., James, V., & Hinsliff-Smith, K. (2011). Maximising graduate status in pre-registration nursing programmes: Utilising problem based learning. Nurse Education in Practice, 11(6), 342-344. doi:10.1016/j.nepr.2010.11.018

This paper debates the use of problem based learning in accelerated pre-registration nursing programmes that are specifically designed for candidates with ‘graduate status’. We discuss the benefits of using problem based learning (PBL) within a gradu... Read More about Maximising graduate status in pre-registration nursing programmes: Utilising problem based learning.

Lameness in UK dairy cows: a review of the current status (2010)
Journal Article
Archer, S. C., Bell, N., & Huxley, J. (2010). Lameness in UK dairy cows: a review of the current status. In Practice, 32(10), https://doi.org/10.1136/inp.c6672

Lameness in dairy cattle has been reported as a concern for welfare and economic reasons for over 20 years. This concern has been expressed from across the industry and has prompted the launch of a number of initiatives to address the problem. This a... Read More about Lameness in UK dairy cows: a review of the current status.

Sortase anchored proteins of Streptococcus uberis play major roles in the pathogenesis of bovine mastitis in dairy cattle (2010)
Journal Article
Leigh, J. A., Egan, S. A., Ward, P. N., Field, T. R., & Coffey, T. J. (2010). Sortase anchored proteins of Streptococcus uberis play major roles in the pathogenesis of bovine mastitis in dairy cattle. Veterinary Research, 41(5), Article 63. https://doi.org/10.1051/vetres/2010036

Streptococcus uberis, strain 0140J, contains a single copy sortase A (srtA), encoding a transamidase capable of covalently anchoring specific proteins to peptidoglycan. Unlike the wild-type, an isogenic mutant carrying an inactivating ISS1 insertion... Read More about Sortase anchored proteins of Streptococcus uberis play major roles in the pathogenesis of bovine mastitis in dairy cattle.

Association between milk yield and serial locomotion score assessments in UK dairy cows (2010)
Journal Article
Archer, S. C., Green, M. J., & Huxley, J. (2010). Association between milk yield and serial locomotion score assessments in UK dairy cows. Journal of Dairy Science, 93(9), https://doi.org/10.3168/jds.2010-3062

This study investigated the effect of lameness, measured by serial locomotion scoring over a 12-mo period, on the milk yield of UK dairy cows. The data set consisted of 11,735 records of test-day yield and locomotion scores collected monthly from 1,4... Read More about Association between milk yield and serial locomotion score assessments in UK dairy cows.

Effect of delivery method on the efficacy of Salmonella vaccination in chickens (2010)
Journal Article
Atterbury, R. J., Morris, V., Harrison, D., Tucker, V., Allen, V., Davies, R., & Carrique-Mas, J. (2010). Effect of delivery method on the efficacy of Salmonella vaccination in chickens. Veterinary Record, 167(5), https://doi.org/10.1136/vr.b4884

To investigate whether the efficacy of live vaccines is influenced by the mode of vaccine delivery, a widely-used UK live commercial Salmonella Enteritidis vaccine was delivered to pullet chicks either by spray, in drinking water, or in combination w... Read More about Effect of delivery method on the efficacy of Salmonella vaccination in chickens.

LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing (2010)
Journal Article
James, V., Zhang, Y., Foxler, D. E., de Moor, C. H., Kong, Y. W., Webb, T. M., …Sharp, T. V. (2010). LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proceedings of the National Academy of Sciences, 107(28), 12499-12504. https://doi.org/10.1073/pnas.0914987107

In recent years there have been major advances with respect to the identification of the protein components and mechanisms of microRNA (miRNA) mediated silencing. However, the complete and precise repertoire of components and mechanism(s) of action r... Read More about LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.

Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability (2010)
Journal Article
Carter, S. D., Dent, K. C., Atkins, E., Foster, T. L., Verow, M., Gorny, P., …Barr, J. N. (2010). Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability. FEBS Letters, 584(13), 2786-2790. https://doi.org/10.1016/j.febslet.2010.05.006

Human respiratory syncytial virus (HRSV) is the leading cause of lower respiratory tract disease in infants. The HRSV small hydrophobic (SH) protein plays an important role in HRSV pathogenesis, although its mode of action is unclear. Analysis of the... Read More about Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability.

Identification of sortase A (SrtA) substrates in Streptococcus uberis: evidence for an additional hexapeptide (LPXXXD) sorting motif (2009)
Journal Article
Egan, S. A., Kurian, D., Ward, P. N., Hunt, L., & Leigh, J. A. (2009). Identification of sortase A (SrtA) substrates in Streptococcus uberis: evidence for an additional hexapeptide (LPXXXD) sorting motif. Journal of Proteome Research, 9(2), https://doi.org/10.1021/pr901025w

Sortase (a transamidase) has been shown to be responsible for the covalent attachment of proteins to the bacterial cell wall. Anchoring is effected on secreted proteins containing a specific cell wall motif toward their C-terminus; that for sortase A... Read More about Identification of sortase A (SrtA) substrates in Streptococcus uberis: evidence for an additional hexapeptide (LPXXXD) sorting motif.

Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis (2009)
Journal Article
Rutland, C., Warner, L., Thorpe, A., Alibhai, A., Robinson, T., Shaw, B., …Loughna, S. (2009). Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis. Journal of Anatomy, 214(6), 905-915. https://doi.org/10.1111/j.1469-7580.2009.01079.x

Atrial septal defects are a common congenital heart defect in humans. Although mutations in different genes are now frequently being described, little is known about the processes and mechanisms behind the early stages of atrial septal development. B... Read More about Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis.