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A pharmacy-based private chlamydia screening programme: Results from the first 2 years of screening and treatment (2011)
Journal Article
Anderson, C., & Thornley, T. (2011). A pharmacy-based private chlamydia screening programme: Results from the first 2 years of screening and treatment. International Journal of Clinical Pharmacy, 33(1), 88-91. https://doi.org/10.1007/s11096-010-9460-3

Objective A major UK Pharmacy chain private Chlamydia screening and treatment service began in October 2006. People pay for a screening kit, send off a urine sample, and are informed of their result directly. Treatment is accessed via the pharmacy ch... Read More about A pharmacy-based private chlamydia screening programme: Results from the first 2 years of screening and treatment.

End-stapled homo and hetero collagen triple helices: A click chemistry approach (2010)
Journal Article
Byrne, C., McEwan, P. A., Emsley, J., Fischer, P. M., & Chan, W. C. (2011). End-stapled homo and hetero collagen triple helices: A click chemistry approach. Chemical Communications, 47(9), 2589-2591. https://doi.org/10.1039/c0cc04795c

A CuAAC reaction was established for modular synthesis of end-stapled homo- and hetero-triple helical peptides, generating "clicked" macro-assemblies with enhanced thermal stability. © 2011 The Royal Society of Chemistry.

Protease sensing with nanoparticle based platforms (2010)
Journal Article
Welser, K., Adsley, R., Moore, B. M., Chan, W. C., & Aylott, J. W. (2011). Protease sensing with nanoparticle based platforms. Analyst, 136(1), 29-41. https://doi.org/10.1039/c0an00429d

Nanoparticulate systems in various unique configurations are highly effective at detecting protease activity both in vivo and in vitro. In this article, we have summarised the conventional modern methods for monitoring protease activity, and critical... Read More about Protease sensing with nanoparticle based platforms.

Regulation of neurotoxin production and sporulation by a putative agrBD signaling system in proteolytic Clostridium botulinum (2010)
Journal Article
Cooksley, C. M., Davis, I. J., Winzer, K., Chan, W. C., Peck, M. W., & Minton, N. P. (2010). Regulation of neurotoxin production and sporulation by a putative agrBD signaling system in proteolytic Clostridium botulinum. Applied and Environmental Microbiology, 76(13), 4448-4460. https://doi.org/10.1128/AEM.03038-09

A significant number of genome sequences of Clostridium botulinum and related species have now been determined. In silico analysis of these data revealed the presence of two distinct agr loci (agr-1 and agr-2) in all group I strains, each encoding pu... Read More about Regulation of neurotoxin production and sporulation by a putative agrBD signaling system in proteolytic Clostridium botulinum.

Garlic as an inhibitor of pseudomonas aeruginosa quorum sensing in cystic fibrosis - A pilot randomized controlled trial (2010)
Journal Article
Smyth, A. R., Cifelli, P. M., Ortori, C. A., Righetti, K., Lewis, S., Erskine, P., …Knox, A. (2010). Garlic as an inhibitor of pseudomonas aeruginosa quorum sensing in cystic fibrosis - A pilot randomized controlled trial. Pediatric Pulmonology, 45(4), 356-362. https://doi.org/10.1002/ppul.21193

Pseudomonas aeruginosa forms biofilms in the cystic fibrosis lung. Quorum sensing (QS) controls biofilm maturation, immune evasion, antibiotic tolerance and virulence factor production. Garlic shows QS inhibitory activity in vitro and in animal model... Read More about Garlic as an inhibitor of pseudomonas aeruginosa quorum sensing in cystic fibrosis - A pilot randomized controlled trial.

5-Carboxyfluorescein tagged N-phenylanthranilamide as a tracer reagent for fluorescence polarization: A robust method to screen MAPK pathway allosteric inhibitors (2010)
Journal Article
Rezvani, Z. N., Mayer, R. J., & Chan, W. C. (2010). 5-Carboxyfluorescein tagged N-phenylanthranilamide as a tracer reagent for fluorescence polarization: A robust method to screen MAPK pathway allosteric inhibitors. Chemical Communications, 46(12), 2043-2045. https://doi.org/10.1039/b925042e

Fluorescence polarization using Nα-(fluorescein-5- carbonyl)-Nε-(N-[2-fluoro-4-iodophenyl]-3,4- difluoroanthraniloyl)lysyl amide is capable of rapidly identifying inhibitor ligands that bind to an allosteric site in MEK1. © The Royal Society of Chemi... Read More about 5-Carboxyfluorescein tagged N-phenylanthranilamide as a tracer reagent for fluorescence polarization: A robust method to screen MAPK pathway allosteric inhibitors.

High throughput methods applied in biomaterial development and discovery (2010)
Journal Article
Hook, A. L., Anderson, D. G., Langer, R., Williams, P., Davies, M. C., & Alexander, M. R. (2010). High throughput methods applied in biomaterial development and discovery. Biomaterials, 31(2), https://doi.org/10.1016/j.biomaterials.2009.09.037

The high throughput discovery of new materials can be achieved by rapidly screening many different materials synthesised by a combinatorial approach to identify the optimal material that fulfils a particular biomedical application. Here we review the... Read More about High throughput methods applied in biomaterial development and discovery.

A facile method to clickable sensing polymeric nanoparticles (2009)
Journal Article
Welser, K., Perera, M. D., Aylott, J. W., & Chan, W. C. (2009). A facile method to clickable sensing polymeric nanoparticles. Chemical Communications, 6601-6603. https://doi.org/10.1039/b914358k

Clickable biocompatible nanoparticles were prepared in a one-pot process by microemulsion polymerization using acrylamide, N,N′-methylene bisacrylamide and either N-(11-azido-3,6,9-trioxaundecanyl)acrylamide or N-propargylacrylamide, which were then... Read More about A facile method to clickable sensing polymeric nanoparticles.

Facile synthesis of responsive nanoparticles with reversible, tunable and rapid thermal transitions from biocompatible constituents (2009)
Journal Article
Abulateefeh, S. R., Saeed, A. O., Aylott, J. W., Chan, W. C., Garnett, M. C., Saunders, B. R., & Alexander, C. (2009). Facile synthesis of responsive nanoparticles with reversible, tunable and rapid thermal transitions from biocompatible constituents. Chemical Communications, 6068-6070. https://doi.org/10.1039/b911986h

Responsive polymeric nanoparticles composed of hybrid block co-polymers were prepared from biocompatible components that displayed rapid, tunable and multiply reversible transitions in response to change of temperature. © 2009 The Royal Society of Ch... Read More about Facile synthesis of responsive nanoparticles with reversible, tunable and rapid thermal transitions from biocompatible constituents.

Protease responsive nanoprobes with tethered fluorogenic peptidyl 3-arylcoumarin substrates (2008)
Journal Article
Welser, K., Grilj, J., Vauthey, E., Aylott, J. W., & Chan, W. C. (2009). Protease responsive nanoprobes with tethered fluorogenic peptidyl 3-arylcoumarin substrates. Chemical Communications, 671-673. https://doi.org/10.1039/b816637d

Protease responsive nanosensors were obtained by the attachment of unique green fluorescent bifunctional 3-arylcoumarin-derived fluorogenic substrates to poly(acrylamide-co-N-(3-aminopropyl)methacrylamide) nanoparticles, in which proteolysis results... Read More about Protease responsive nanoprobes with tethered fluorogenic peptidyl 3-arylcoumarin substrates.

A macroporous polymer-supported cyclic anhydride for efficient sequestration of amines (2008)
Journal Article
Sanna, M., White, P. D., & Chan, W. C. (2008). A macroporous polymer-supported cyclic anhydride for efficient sequestration of amines. Tetrahedron Letters, 49(42), 6160-6162. https://doi.org/10.1016/j.tetlet.2008.08.038

The efficient removal of primary and secondary amines from organic solutions using a macroporous polymer-supported anhydride is described. The sequestering of primary amines by the anhydride via polymer-bound amide formation is completed within 2-4 h... Read More about A macroporous polymer-supported cyclic anhydride for efficient sequestration of amines.

Differential Recognition of Staphylococcus aureus Quorum-Sensing Signals Depends on Both Extracellular Loops 1 and 2 of the Transmembrane Sensor AgrC (2008)
Journal Article
Jensen, R. O., Winzer, K., Clarke, S. R., Chan, W. C., & Williams, P. (2008). Differential Recognition of Staphylococcus aureus Quorum-Sensing Signals Depends on Both Extracellular Loops 1 and 2 of the Transmembrane Sensor AgrC. Journal of Molecular Biology, 381(2), 300-309. https://doi.org/10.1016/j.jmb.2008.06.018

Virulence in Staphylococcus aureus is regulated via agr-dependent quorum sensing in which an autoinducing peptide (AIP) activates AgrC, a histidine protein kinase. AIPs are usually thiolactones containing seven to nine amino acid residues in which th... Read More about Differential Recognition of Staphylococcus aureus Quorum-Sensing Signals Depends on Both Extracellular Loops 1 and 2 of the Transmembrane Sensor AgrC.

Targeting of polyamidoamine-DNA nanoparticles using the Staudinger ligation: Attachment of an RGD motif either before or after complexation (2008)
Journal Article
Parkhouse, S. M., Garnett, M. C., & Chan, W. C. (2008). Targeting of polyamidoamine-DNA nanoparticles using the Staudinger ligation: Attachment of an RGD motif either before or after complexation. Bioorganic and Medicinal Chemistry, 16(13), 6641-6650. https://doi.org/10.1016/j.bmc.2008.05.023

Two new methods for the modular synthesis of targeted gene delivery systems are reported. The PEGylated polyamidoamine DMEDA-PEG-DMEDA-(MBA-DMEDA)n+1-PEG-DMEDA 3 was sequentially modified to contain an integrin-binding peptide ligand via the Stauding... Read More about Targeting of polyamidoamine-DNA nanoparticles using the Staudinger ligation: Attachment of an RGD motif either before or after complexation.

Molecular mechanism of target recognition by subtilin, a class I lanthionine antibiotic (2008)
Journal Article
Parisot, J., Carey, S., Breukink, E., Chan, W. C., Narbad, A., & Bonev, B. (2008). Molecular mechanism of target recognition by subtilin, a class I lanthionine antibiotic. Antimicrobial Agents and Chemotherapy, 52(2), 612-618. https://doi.org/10.1128/AAC.00836-07

The increasing resistance of human pathogens to conventional antibiotics presents a growing threat to the chemotherapeutic management of infectious diseases. The lanthionine antibiotics, still unused as therapeutic agents, have recently attracted sig... Read More about Molecular mechanism of target recognition by subtilin, a class I lanthionine antibiotic.

Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels (2007)
Journal Article
Pardon, M. C., Sarmad, S., Rattray, I., Bates, T. E., Scullion, G. A., Marsden, C. A., …Kendall, D. A. (2007). Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels. Neurobiology of Aging, 30(7), 1099-1113. https://doi.org/10.1016/j.neurobiolaging.2007.10.002

Environmental factors (e.g. stress, exercise, enrichment) are thought to play a role in the development of Alzheimer's disease later in life. We investigated the influence of repeated novel cage exposure on the development of early Alzheimer's-like p... Read More about Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels.