Protease responsive nanoprobes with tethered fluorogenic peptidyl 3-arylcoumarin substrates

Welser, Katharina; Grilj, Jakob; Vauthey, Eric; Aylott, Jonathan W.; Chan, Weng C.

Abstract

Protease responsive nanosensors were obtained by the attachment of unique green fluorescent bifunctional 3-arylcoumarin-derived fluorogenic substrates to poly(acrylamide-co-N-(3-aminopropyl)methacrylamide) nanoparticles, in which proteolysis results in substantial signal amplification. © The Royal Society of Chemistry 2009.

Citation

Welser, K., Grilj, J., Vauthey, E., Aylott, J. W., & Chan, W. C. (2009). Protease responsive nanoprobes with tethered fluorogenic peptidyl 3-arylcoumarin substrates. Chemical Communications, 671-673. https://doi.org/10.1039/b816637d

• Journal Article Type: Article
• Acceptance Date: Nov 13, 2008
• Online Publication Date: Dec 8, 2008
• Publication Date: Feb 2, 2009
• Deposit Date: Sep 10, 2020
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Issue: 6
• Pages: 671-673
• DOI: https://doi.org/10.1039/b816637d
• Public URL: https://nottingham-repository.worktribe.com/output/3137709
• Publisher URL: https://pubs.rsc.org/en/content/articlelanding/2009/CC/B816637D#!divAbstract