All Outputs (532)

New horizons: the management of hypertension in people with dementia (2016)
Journal Article
Harrison, J. K., Van Der Wardt, V., Conroy, S. P., Stott, D. J., Dening, T., Gordon, A. L., …Gladman, J. R. (2016). New horizons: the management of hypertension in people with dementia. Age and Ageing, 45(6), 740-746. https://doi.org/10.1093/ageing/afw155

The optimal management of hypertension in people with dementia is uncertain. This review explores if people with dementia experience greater adverse effects from antihypertensive medications, if cognitive function is protected or worsened by controll... Read More about New horizons: the management of hypertension in people with dementia.

Psychological morbidity and health related quality of life after injury: multicentre cohort study (2016)
Journal Article
Kendrick, D., Kellezi, B., Coupland, C., Maula, A., Beckett, K., Morriss, R. K., …Christie, N. (2017). Psychological morbidity and health related quality of life after injury: multicentre cohort study. Quality of Life Research, 26(5), 1233-1250. https://doi.org/10.1007/s11136-016-1439-7

Purpose: To demonstrate the impact of psychological morbidity one month post-injury on subsequent post-injury quality of life (HRQoL) in a general injury population in the UK to inform development of trauma care and rehabilitation services. Method... Read More about Psychological morbidity and health related quality of life after injury: multicentre cohort study.

Short-term breast cancer survival in relation to ethnicity, stage, grade and receptor status: National cohort study in England (2016)
Journal Article
Møller, H., Henson, K., Lüchtenborg, M., Broggio, J., Charman, J., Coupland, V. H., …Purushotham, A. (2016). Short-term breast cancer survival in relation to ethnicity, stage, grade and receptor status: National cohort study in England. British Journal of Cancer, 115(11), 1408-1415. https://doi.org/10.1038/bjc.2016.335

Background:In the re-organisation of cancer registration in England in 2012, a high priority was given to the recording of cancer stage and other prognostic clinical data items.Methods:We extracted 86 852 breast cancer records for women resident in E... Read More about Short-term breast cancer survival in relation to ethnicity, stage, grade and receptor status: National cohort study in England.

Antenatal clinic and Stop Smoking Services staff views on "Opt-Out" referrals for smoking cessation in pregnancy: a framework analysis (2016)
Journal Article
Campbell, K., Bowker, K., Naughton, F., Sloan, M., Cooper, S., & Coleman, T. (2016). Antenatal clinic and Stop Smoking Services staff views on "Opt-Out" referrals for smoking cessation in pregnancy: a framework analysis. International Journal of Environmental Research and Public Health, 13(10), Article 1004. https://doi.org/10.3390/ijerph13101004

Introduction: UK guidance recommends routine exhaled carbon monoxide (CO) screening for pregnant women and “opt-out” referrals to stop smoking services (SSS) of those with CO ≥ 4 ppm. We explored staff views on this referral pathway when implemented... Read More about Antenatal clinic and Stop Smoking Services staff views on "Opt-Out" referrals for smoking cessation in pregnancy: a framework analysis.

Usual medical treatments or levonorgestrel-IUS for women with heavy menstrual bleeding: long-term ranomised pragmatic trial in primary care (2016)
Journal Article
Kai, J., Middleton, L., Daniels, J., Pattison, H., Tryposkiadis, K., & Gupta, J. (in press). Usual medical treatments or levonorgestrel-IUS for women with heavy menstrual bleeding: long-term ranomised pragmatic trial in primary care. British Journal of General Practice, 66(653), Article e861-e870. https://doi.org/10.3399/bjgp16X687577

Background: Heavy menstrual bleeding (HMB) is a common, chronic problem burdening women and health services. However long-term evidence on treatment in primary care is lacking. Aim: To assess the effectiveness of commencing levonorgestrel intra-ut... Read More about Usual medical treatments or levonorgestrel-IUS for women with heavy menstrual bleeding: long-term ranomised pragmatic trial in primary care.

The Community In-reach Rehabilitation and Care Transition (CIRACT) clinical and cost-effectiveness randomisation controlled trial in older people admitted to hospital as an acute medical emergency (2016)
Journal Article
Sahota, O., Pulikottil-Jacob, R., Marshall, F., Montgomery, A., Tan, W., Sach, T., …Waring, J. (in press). The Community In-reach Rehabilitation and Care Transition (CIRACT) clinical and cost-effectiveness randomisation controlled trial in older people admitted to hospital as an acute medical emergency. Age and Ageing, 46(1), https://doi.org/10.1093/ageing/afw149

Objective: To compare the clinical and cost-effectiveness of a Community In-reach Rehabilitation and Care Transition (CIRACT) service with the traditional hospital-based rehabilitation (THB-Rehab) service. Design: Pragmatic randomised controlled... Read More about The Community In-reach Rehabilitation and Care Transition (CIRACT) clinical and cost-effectiveness randomisation controlled trial in older people admitted to hospital as an acute medical emergency.

Cognitive behaviour therapy for long-term frequent attenders in primary care: a feasibility case series and treatment development study (2016)
Journal Article
Malins, S., Kai, J., Atha, C., Avery, A., Guo, B., James, M., …Morriss, R. K. (2016). Cognitive behaviour therapy for long-term frequent attenders in primary care: a feasibility case series and treatment development study. British Journal of General Practice, 66(651), e729-e736. https://doi.org/10.3399/bjgp16X686569

Background: Most frequent attendance in primary care is temporary. Long-term frequent attendance may be suitable for psychological intervention to address health management and service use. Aim: To explore the feasibility and acceptability of cog... Read More about Cognitive behaviour therapy for long-term frequent attenders in primary care: a feasibility case series and treatment development study.

The application of protein microarray assays in psychoneuroimmunology (2016)
Journal Article
Ayling, K., Bowden, T., Tighe, P., Todd, I., Dilnot, E. M., Negm, O., …Vedhara, K. (2017). The application of protein microarray assays in psychoneuroimmunology. Brain, Behavior, and Immunity, 59, 62-66. https://doi.org/10.1016/j.bbi.2016.09.013

Protein microarrays are miniaturized multiplex assays that exhibit many advantages over the commonly used enzyme-linked immunosorbent assay (ELISA). This article aims to introduce protein microarrays to readers of Brain, Behavior, and Immunity and de... Read More about The application of protein microarray assays in psychoneuroimmunology.

Protecting children from secondhand smoke: a mixed-methods feasibility study of a novel smoke-free home intervention (2016)
Journal Article
Marsh, J., McNeill, A., Lewis, S., Coleman, T., Bains, M., Larwood, A., …Jones, L. L. (2016). Protecting children from secondhand smoke: a mixed-methods feasibility study of a novel smoke-free home intervention. Pilot and Feasibility Studies, 2, Article 53. https://doi.org/10.1186/s40814-016-0094-7

Background: Globally, 40 % of children under 14 years are regularly exposed to secondhand smoke (SHS), typically in their homes. There is limited evidence of the effectiveness of interventions to reduce children’s SHS exposure,and so the aim of this... Read More about Protecting children from secondhand smoke: a mixed-methods feasibility study of a novel smoke-free home intervention.

Multicentre, prospective, randomised, open-label, blinded end point trial of the efficacy of allopurinol therapy in improving cardiovascular outcomes in patients with ischaemic heart disease: protocol of the ALL-HEART study (2016)
Journal Article
Mackenzie, I. S., Ford, I., Walker, A., Hawkey, C., Begg, A., Avery, A., …MacDonald, T. M. (2016). Multicentre, prospective, randomised, open-label, blinded end point trial of the efficacy of allopurinol therapy in improving cardiovascular outcomes in patients with ischaemic heart disease: protocol of the ALL-HEART study. BMJ Open, 6(9), Article e013774. https://doi.org/10.1136/bmjopen-2016-013774

Introduction Ischaemic heart disease (IHD) is one of the most common causes of death in the UK and treatment of patients with IHD costs the National Health System (NHS) billions of pounds each year. Allopurinol is a xanthine oxidase inhibitor use... Read More about Multicentre, prospective, randomised, open-label, blinded end point trial of the efficacy of allopurinol therapy in improving cardiovascular outcomes in patients with ischaemic heart disease: protocol of the ALL-HEART study.

Characterising the nature of primary care patient safety incident reports in the England and Wales National Reporting and Learning System: a mixed-methods agenda-setting study for general practice (2016)
Journal Article
Carson-Stevens, A., Hibbert, P., Williams, H., Prosser Evans, H., Cooper, A., Rees, P., …Edwards, A. (2016). Characterising the nature of primary care patient safety incident reports in the England and Wales National Reporting and Learning System: a mixed-methods agenda-setting study for general practice. Health Services and Delivery Research, 4(27), 1-76. https://doi.org/10.3310/hsdr04270

Background There is an emerging interest in the inadvertent harm caused to patients by the provision of primary health-care services. To date (up to 2015), there has been limited research interest and few policy directives focused on patient saf... Read More about Characterising the nature of primary care patient safety incident reports in the England and Wales National Reporting and Learning System: a mixed-methods agenda-setting study for general practice.

Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF (2016)
Journal Article
Massey, A., Campbell, B. K., Raine-Fenning, N., Pincott-Allen, C., Perry, J., & Vedhara, K. (2016). Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF. Psychoneuroendocrinology, 74, https://doi.org/10.1016/j.psyneuen.2016.08.027

Evidence for an association between cortisol and clinical pregnancy in women undergoing In Vitro Fertilisation (IVF) is mixed with previous studies relying exclusively on short term measures of cortisol in blood, saliva, urine, and/or follicular flui... Read More about Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF.

Modifiable risk factors for scald injury in children under 5 years of age: a multi-centre case–control study (2016)
Journal Article
Stewart, J., Benford, P., Wynn, P., Watson, M. C., Coupland, C., Deave, T., …Kendrick, D. (2016). Modifiable risk factors for scald injury in children under 5 years of age: a multi-centre case–control study. Burns, 42(8), 1831-1843. https://doi.org/10.1016/j.burns.2016.06.027

Objective: To determine the relationship between a range of modifiable risk factors and medically attended scalds in children under the age of 5 years. Methods: Multicentre matched case-control study in acute hospitals, minor injury units and GP pr... Read More about Modifiable risk factors for scald injury in children under 5 years of age: a multi-centre case–control study.

Differing patterns in intentional and unintentional poisonings among young people in England, 1998-2014: a population based cohort study (2016)
Journal Article
Tyrrell, E. G., Orton, E., Sayal, K., Baker, R., & Kendrick, D. (2017). Differing patterns in intentional and unintentional poisonings among young people in England, 1998-2014: a population based cohort study. Journal of Public Health, 39(2), Article e1-e9. https://doi.org/10.1093/pubmed/fdw075

Background Accurate and up to date data on changes in poisoning incidence among young people are lacking. Recent linkage of UK primary care, hospital and mortality data allows these to be quantified to inform service delivery. Methods An open coh... Read More about Differing patterns in intentional and unintentional poisonings among young people in England, 1998-2014: a population based cohort study.

A decision analytic model to investigate the cost-effectiveness of poisoning prevention practices in households with young children (2016)
Journal Article
Achana, F., Sutton, A. J., Kendrick, D., Hayes, M., Jones, D. R., Hubbard, S. J., & Cooper, N. J. (2016). A decision analytic model to investigate the cost-effectiveness of poisoning prevention practices in households with young children. BMC Public Health, 16, Article 705. https://doi.org/10.1186/s12889-016-3334-0

Background: Systematic reviews and a network meta-analysis show home safety education with or without the provision of safety equipment is effective in promoting poison prevention behaviours in households with children. This paper compares the cost-e... Read More about A decision analytic model to investigate the cost-effectiveness of poisoning prevention practices in households with young children.

Anxiety associated with diagnostic uncertainties in early pregnancy. (2016)
Journal Article
Richardson, A., Raine-Fenning, N., Deb, S., Campbell, B., & Vedhara, K. (in press). Anxiety associated with diagnostic uncertainties in early pregnancy. Ultrasound in Obstetrics and Gynaecology, https://doi.org/10.1002/uog.17214

Objectives: To determine anxiety levels of women presenting to Early Pregnancy Assessment Units (EPAU) with abdominal pain and/or vaginal bleeding and assess how these change over time and according to ultrasonographic diagnosis. Methods: We under... Read More about Anxiety associated with diagnostic uncertainties in early pregnancy..

Diabetes treatments and risk of heart failure, cardiovascular disease and all-cause mortality: cohort study in primary care (2016)
Journal Article
Hippisley-Cox, J., & Coupland, C. (2016). Diabetes treatments and risk of heart failure, cardiovascular disease and all-cause mortality: cohort study in primary care. BMJ, 354(i3477), https://doi.org/10.1136/bmj.i3477

Objective: To assess associations between risks of cardiovascular disease, heart failure, and all cause mortality and different diabetes drugs in people with type 2 diabetes, particularly newer agents, including gliptins and thiazolidinediones (glita... Read More about Diabetes treatments and risk of heart failure, cardiovascular disease and all-cause mortality: cohort study in primary care.

Comparing the case mix and survival of women receiving breast cancer care from one private provider with other London women with breast cancer: Pilot data exchange and analyses (2016)
Journal Article
Davies, E. A., Coupland, V. H., Dixon, S., Mokbel, K., & Jack, R. H. (2016). Comparing the case mix and survival of women receiving breast cancer care from one private provider with other London women with breast cancer: Pilot data exchange and analyses. BMC Cancer, 16(1), https://doi.org/10.1186/s12885-016-2439-2

© 2016 The Author(s). Background: Data from providers of private cancer care are not yet formally included in English cancer registration data. This study aimed to test the exchange of breast cancer data from one Hospital Corporation of America Inter... Read More about Comparing the case mix and survival of women receiving breast cancer care from one private provider with other London women with breast cancer: Pilot data exchange and analyses.

Reducing falls among older people in general practice: the ProAct65+ exercise intervention trial (2016)
Journal Article
Gawler, S., Skelton, D. A., Dinan-Young, S., Masud, T., Morris, R. W., Griffin, M., …Iliffe, S. (2016). Reducing falls among older people in general practice: the ProAct65+ exercise intervention trial. Archives of Gerontology and Geriatrics, 67, https://doi.org/10.1016/j.archger.2016.06.019

Background: Falls are common in the older UK population and associated costs to the NHS are high. Systematic reviews suggest that home exercise and group-based exercise interventions, which focus on progressively challenging balance and increasing st... Read More about Reducing falls among older people in general practice: the ProAct65+ exercise intervention trial.

Discontinuation and restarting in patients on statin therapy: a cohort study using a primary care database (2016)
Journal Article
Vinogradova, Y., Coupland, C., Brindle, P., & Hippisley-Cox, J. (in press). Discontinuation and restarting in patients on statin therapy: a cohort study using a primary care database. BMJ, 353, Article i3305. https://doi.org/10.1136/bmj.i3305

Objectives: To estimate rates of discontinuation and restarting of statins, and to identify patient characteristics associated with either discontinuation or restarting. Design: Prospective open cohort study. Setting: 664 general practices con... Read More about Discontinuation and restarting in patients on statin therapy: a cohort study using a primary care database.