Anxiety associated with diagnostic uncertainties in early pregnancy.

Richardson, Alison; Raine-Fenning, Nick; Deb, Shilpa; Campbell, Bruce; Vedhara, Kavita

Abstract

Objectives: To determine anxiety levels of women presenting to Early Pregnancy Assessment Units (EPAU) with abdominal pain and/or vaginal bleeding and assess how these change over time and according to ultrasonographic diagnosis.

Methods: We undertook a prospective cohort study in a EPAU in a large UK teaching hospital. Women with abdominal pain and/or vaginal bleeding in early pregnancy (less than 12 weeks gestation) presenting for the first time were eligible for inclusion in the study. State anxiety levels were assessed using the standardised short form of Spielberger's state-trait anxiety inventory on three occasions (before, immediately after and 48–72 hours after an ultrasound scan). Scores were correlated with ultrasonographic diagnosis. The diagnosis was either certain or uncertain. Certain diagnoses were either positive i.e. a viable intrauterine pregnancy (IUP), or negative i.e. a non-viable IUP or ectopic pregnancy (EP). Uncertain diagnoses included pregnancies of unknown location (PUL) and uncertain viability (PUV). Statistical analysis involved mixed ANOVAs and the post-hoc Tukey-Kramer test.

Results: 160 women were included in the study. Anxiety levels decreased over time for women with certain diagnoses (n = 128), even when negative (n = 64), and increased over time for women with uncertain diagnoses (n = 32). Before the ultrasound, anxiety levels were high (21.96 ± 1.11) and there was no significant difference between the five groups. Immediately after the ultrasound, anxiety levels were lower in the viable IUP group (n = 64; 7.75 ± 1.13) than any other group. The difference between the five groups was significant (p 

Citation

Richardson, A., Raine-Fenning, N., Deb, S., Campbell, B., & Vedhara, K. (in press). Anxiety associated with diagnostic uncertainties in early pregnancy. Ultrasound in Obstetrics and Gynaecology, https://doi.org/10.1002/uog.17214

• Journal Article Type: Article
• Acceptance Date: Jul 20, 2016
• Online Publication Date: Aug 3, 2016
• Deposit Date: Aug 23, 2016
• Publicly Available Date: Aug 23, 2016
• Journal: Ultrasound in Obstetrics & Gynaecology
• Electronic ISSN: 1469-0705
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1002/uog.17214
• Keywords: pregnancy; anxiety; diagnostic uncertainty; Spielberger.
• Public URL: https://nottingham-repository.worktribe.com/output/806802
• Publisher URL: http://onlinelibrary.wiley.com/doi/10.1002/uog.17214/abstract
• Additional Information: This is the peer reviewed version of the following article: Richardson A, Raine-Fenning N, Deb S, Campbell B, Vedhara K. (2016) Anxiety associated with diagnostic uncertainties in early pregnancy. Ultrasound in Obstetrics & Gynecology, which has been published in final form at doi: 10.1002/uog.17214. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.