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Mefloquine loaded niosomes as a promising approach for the treatment of acute and chronic toxoplasmosis (2022)
Journal Article
El Sharazly, B. M., Aboul Asaad, I. A., Yassen, N. A., El Maghraby, G. M., Carter, W. G., Mohamed, D. A., …Ismail, H. I. (2023). Mefloquine loaded niosomes as a promising approach for the treatment of acute and chronic toxoplasmosis. Acta Tropica, 239, Article 106810. https://doi.org/10.1016/j.actatropica.2022.106810

Toxoplasmosis is a disease with a worldwide distribution and significant morbidity and mortality. In search of effective treatment, mefloquine (MQ) was repurposed and loaded with niosomes to treat acute and chronic phases of toxoplasmosis in experime... Read More about Mefloquine loaded niosomes as a promising approach for the treatment of acute and chronic toxoplasmosis.

The Potential of Stilbene Compounds to Inhibit Mpro Protease as a Natural Treatment Strategy for Coronavirus Disease-2019 (2022)
Journal Article
Naseem, A., Rasool, F., Ahmed, A., & Carter, W. G. (2023). The Potential of Stilbene Compounds to Inhibit Mpro Protease as a Natural Treatment Strategy for Coronavirus Disease-2019. Current Issues in Molecular Biology, 45(1), 12-32. https://doi.org/10.3390/cimb45010002

COVID-19 disease has had a global impact on human health with increased levels of morbidity and mortality. There is an unmet need to design and produce effective antivirals to treat COVID-19. This study aimed to explore the potential ability of natur... Read More about The Potential of Stilbene Compounds to Inhibit Mpro Protease as a Natural Treatment Strategy for Coronavirus Disease-2019.

Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men (2022)
Journal Article
Abdulla, H., Phillips, B., Wilkinson, D., Gates, A., Limb, M., Jandova, T., …Atherton, P. (2023). Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men. Journal of Clinical Endocrinology and Metabolism, 108(4), 971-978. https://doi.org/10.1210/clinem/dgac613

Introduction Ageing skeletal muscles become both insulin resistant and atrophic. The hormone glucagon-like peptide 1 (GLP-1) facilitates postprandial glucose uptake as well as augmenting muscle perfusion, independent of insulin action. We thus hypot... Read More about Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men.

Usability: An introduction to and literature review of usability testing for educational resources in radiation oncology (2022)
Journal Article
Keenan, H. L., Duke, S. L., Wharrad, H. J., Doody, G. A., & Patel, R. S. (2022). Usability: An introduction to and literature review of usability testing for educational resources in radiation oncology. Technical Innovations & Patient Support in Radiation Oncology, 24, 67-72. https://doi.org/10.1016/j.tipsro.2022.09.001

Usability, or the ease with which something can be used, is a key aspect in ensuring end-users can achieve the best possible outcomes from a given educational resource. Ideally usability testing should take place iteratively throughout the design of... Read More about Usability: An introduction to and literature review of usability testing for educational resources in radiation oncology.

Clinical predictors of antipsychotic treatment resistance: Development and internal validation of a prognostic prediction model by the STRATA-G consortium (2022)
Journal Article
Smart, S. E., Agbedjro, D., Pardiñas, A. F., Ajnakina, O., Alameda, L., Andreassen, O. A., …MacCabe, J. H. (2022). Clinical predictors of antipsychotic treatment resistance: Development and internal validation of a prognostic prediction model by the STRATA-G consortium. Schizophrenia Research, 250, 1-9. https://doi.org/10.1016/j.schres.2022.09.009

Our aim was to, firstly, identify characteristics at first-episode of psychosis that are associated with later antipsychotic treatment resistance (TR) and, secondly, to develop a parsimonious prediction model for TR. We combined data from ten prospec... Read More about Clinical predictors of antipsychotic treatment resistance: Development and internal validation of a prognostic prediction model by the STRATA-G consortium.

Motor unit dysregulation following 15 days of unilateral lower limb immobilisation (2022)
Journal Article
Inns, T. B., Bass, J. J., Hardy, E. J., Wilkinson, D. J., Stashuk, D. W., Atherton, P. J., …Piasecki, M. (2022). Motor unit dysregulation following 15 days of unilateral lower limb immobilisation. Journal of Physiology, 600(21), 4753-4769. https://doi.org/10.1113/jp283425

Abstract: Disuse atrophy, caused by situations of unloading such as limb immobilisation, causes a rapid yet diverging reduction in skeletal muscle function when compared to muscle mass. While mechanistic insight into the loss of mass is well studied,... Read More about Motor unit dysregulation following 15 days of unilateral lower limb immobilisation.

Factors associated with the timely completion of doctoral research studies in clinical pharmacy: A mixed-methods study (2022)
Journal Article
Mosanya, A. U., Ukoha-kalu, B. O., Isah, A., Umeh, I., Amorha, K. C., Ayogu, E. E., & Ubaka, C. (2022). Factors associated with the timely completion of doctoral research studies in clinical pharmacy: A mixed-methods study. PLoS ONE, 17(9), Article e0274638. https://doi.org/10.1371/journal.pone.0274638

Introduction There is growing scientific evidence of mental and well-being issues that doctoral research students face as a result of not finishing their program on time. This study aims to explore the factors associated with the timely completion o... Read More about Factors associated with the timely completion of doctoral research studies in clinical pharmacy: A mixed-methods study.

Rise of the Med-Ed-ists: Achieving a critical mass of non-practicing clinicians within medical education (2022)
Journal Article
Church, H., & Brown, M. E. L. (2022). Rise of the Med-Ed-ists: Achieving a critical mass of non-practicing clinicians within medical education. Medical Education, 56(12), 1160-1162. https://doi.org/10.1111/medu.14940

In the latest "Connections" article, Church and Brown use the concept of 'critical mass' to explain how stigma, lack of career pathways and prioritization of clinical seniority may discourage non-practicing clinicians from becoming educationalists.

A Preliminary Assessment of the Nutraceutical Potential of Acai Berry (Euterpe sp.) as a Potential Natural Treatment for Alzheimer's Disease (2022)
Journal Article
AL Nasser, M. N., Mellor, I. R., & Carter, W. G. (2022). A Preliminary Assessment of the Nutraceutical Potential of Acai Berry (Euterpe sp.) as a Potential Natural Treatment for Alzheimer's Disease. Molecules, 27(15), Article 4891. https://doi.org/10.3390/molecules27154891

Alzheimer's disease (AD) is characterised by progressive neuronal atrophy and the loss of neuronal function as a consequence of multiple pathomechanisms. Current AD treatments primarily operate at a symptomatic level to treat a cholinergic deficiency... Read More about A Preliminary Assessment of the Nutraceutical Potential of Acai Berry (Euterpe sp.) as a Potential Natural Treatment for Alzheimer's Disease.

An Investigation of the Neurotoxic Effects of Malathion, Chlorpyrifos, and Paraquat to Different Brain Regions (2022)
Journal Article
Elmorsy, E., Al-Ghafari, A., Al Doghaither, H., Salama, M., & Carter, W. G. (2022). An Investigation of the Neurotoxic Effects of Malathion, Chlorpyrifos, and Paraquat to Different Brain Regions. Brain Sciences, 12(8), Article 975. https://doi.org/10.3390/brainsci12080975

Acute or chronic exposures to pesticides have been linked to neurotoxicity and the potential development of neurodegenerative diseases (NDDs). This study aimed to consider the neurotoxicity of three widely utilized pesticides: malathion, chlorpyrifos... Read More about An Investigation of the Neurotoxic Effects of Malathion, Chlorpyrifos, and Paraquat to Different Brain Regions.

Applying educational theory to medical education research (2022)
Journal Article
Melvin, A., & Patel, R. S. (2022). Applying educational theory to medical education research. Clinical and Experimental Dermatology, 47(12), 2085-2089. https://doi.org/10.1111/ced.15287

Applying educational theory to medical education research is no different to the way theory drives research and practice in other domains. However, the practical application of theory to research in medical education can often be challenging for many... Read More about Applying educational theory to medical education research.

The Psychological Impact of Coronavirus Disease 2019 on Patients Attending a Tertiary Healthcare Facility in Pakistan: A Cross-Sectional Study (2022)
Journal Article
Ali, U. A., Iftikhar, N., Amat-Ur-rasool, H., Ahmed, M., Hafeez, J., & Carter, W. G. (2022). The Psychological Impact of Coronavirus Disease 2019 on Patients Attending a Tertiary Healthcare Facility in Pakistan: A Cross-Sectional Study. Healthcare, 10(6), Article 1049. https://doi.org/10.3390/healthcare10061049

The COVID-19 pandemic has had a damaging impact on global health. Post-infection, patients may experience mental health difficulties and therefore require suitable psychological treatment and support. The objective of this study was to identify the p... Read More about The Psychological Impact of Coronavirus Disease 2019 on Patients Attending a Tertiary Healthcare Facility in Pakistan: A Cross-Sectional Study.

Is L-Glutamate Toxic to Neurons and Thereby Contributes to Neuronal Loss and Neurodegeneration? A Systematic Review (2022)
Journal Article
Al-Nasser, M. N., Mellor, I. R., & Carter, W. G. (2022). Is L-Glutamate Toxic to Neurons and Thereby Contributes to Neuronal Loss and Neurodegeneration? A Systematic Review. Brain Sciences, 12(5), Article 577. https://doi.org/10.3390/brainsci12050577

L-glutamate (L-Glu) is a nonessential amino acid, but an extensively utilised excitatory neurotransmitter with critical roles in normal brain function. Aberrant accumulation of L-Glu has been linked to neurotoxicity and neurodegeneration. To investig... Read More about Is L-Glutamate Toxic to Neurons and Thereby Contributes to Neuronal Loss and Neurodegeneration? A Systematic Review.

Barriers and facilitators for implementation of a national recommended specialty core-curriculum across UK medical schools: a cross-sectional study using an online questionnaire (2022)
Journal Article
Sharma, M., Murphy, R., & Doody, G. A. (2022). Barriers and facilitators for implementation of a national recommended specialty core-curriculum across UK medical schools: a cross-sectional study using an online questionnaire. BMJ Open, 12(3), Article e053565

Objectives The National Health Service (NHS) Long-Term plan published in 2019 set out healthcare reforms to meet the healthcare demands of UK. Undergraduate specialty core-curricula like dermatology aligns well to the training needs of the future wor... Read More about Barriers and facilitators for implementation of a national recommended specialty core-curriculum across UK medical schools: a cross-sectional study using an online questionnaire.

Perceptions of transition into clinical placement (2022)
Journal Article
Scott, N. L., Mahran, S., Patel, R., & Culshaw, M. (2022). Perceptions of transition into clinical placement. Clinical Teacher, 19(2), 129-135. https://doi.org/10.1111/tct.13465

Introduction A major transition for medical students is the change from the pre-clinical to clinical years of their curriculum. Interventions to help students manage this transition effectively, such as preparatory skills courses and peer mentoring,... Read More about Perceptions of transition into clinical placement.

Flexible portfolio training: a novel approach to future physician training (2022)
Journal Article
Saville, R. L., Bowman, R., & Patel, R. (2022). Flexible portfolio training: a novel approach to future physician training. Future Healthcare Journal, 9(1), 13-17. https://doi.org/10.7861/fhj.2021-0143

Flexible portfolio training (FPT) is a novel Royal College of Physicians' training scheme developed in 2019 to tackle issues of burnout, retention and recruitment among medical registrars. Awareness of the FPT scheme may be lacking and this article i... Read More about Flexible portfolio training: a novel approach to future physician training.

Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants with Treatment Resistance in Schizophrenia (2022)
Journal Article
Pardiñas, A. F., Smart, S. E., Willcocks, I. R., Holmans, P. A., Dennison, C. A., Lynham, A. J., …Vázquez-Bourgon, J. (2022). Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants with Treatment Resistance in Schizophrenia. JAMA Psychiatry, 79(3), 260-269. https://doi.org/10.1001/jamapsychiatry.2021.3799

Importance: About 20% to 30% of people with schizophrenia have psychotic symptoms that do not respond adequately to first-line antipsychotic treatment. This clinical presentation, chronic and highly disabling, is known as treatment-resistant schizoph... Read More about Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants with Treatment Resistance in Schizophrenia.