All Outputs (71)

Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy (2019)
Journal Article

Invasive lobular carcinoma comprises 10–15% of all breast cancers and is increasingly recognised as a distinct and understudied disease compared with the predominant histological subtype, invasive ductal carcinoma. Hallmarks of invasive lobular carci... Read More about Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy.

Clinical characteristics and patient treatment satisfaction with Humalog U-200 in patients with type 2 diabetes mellitus: an observational study (2019)
Journal Article

Background There is limited data on the real world evidence of Humalog 200 units/ml KwikPen (U-200) insulin. We assessed the use of U-200 insulin in UK routine clinical practice to provide information on clinical characteristics, treatment satisfacti... Read More about Clinical characteristics and patient treatment satisfaction with Humalog U-200 in patients with type 2 diabetes mellitus: an observational study.

Validation of the European Renal Best Practice guideline algorithm for management of older patients with advanced chronic kidney disease: a commentary (2019)
Journal Article

Proliferation and AKT activity biomarker analyses after Capivasertib (AZD5363) treatment of patients with ER+ invasive breast cancer (STAKT) (2019)
Journal Article

© 2020 American Association for Cancer Research Inc.. All rights reserved. Purpose: The STAKT study examined short-term exposure (4.5 days) to the oral selective pan-AKT inhibitor capivasertib (AZD5363) to determine if this drug can reach its therape... Read More about Proliferation and AKT activity biomarker analyses after Capivasertib (AZD5363) treatment of patients with ER+ invasive breast cancer (STAKT).

Coffee Consumption and Kidney Function: A Mendelian Randomization Study (2019)
Journal Article

Rationale & Objective Chronic kidney disease (CKD) is a leading cause of morbidity and mortality worldwide, with limited strategies for prevention and treatment. Coffee is a complex mixture of chemicals, and consumption has been associated with mo... Read More about Coffee Consumption and Kidney Function: A Mendelian Randomization Study.

Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome (2019)
Journal Article

Introduction Pre-eclampsia is a hypertensive gestational disorder that affects approximately 5% of all pregnancies. Objectives As the pathophysiological processes of pre-eclampsia are still uncertain, the present case–control study explored unde... Read More about Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome.

Remote Ischemic Conditioning After Stroke Trial 2: A Phase IIb Randomized Controlled Trial in Hyperacute Stroke (2019)
Journal Article

Personalising Care in the Older Woman with Primary Breast Cancer (2019)
Journal Article

The incidence of breast cancer increases with age. Despite this, most research in the field is targeted at younger patients. Age-specific guidelines are not widely referred to and guidelines which allude to the older woman as an individual are based... Read More about Personalising Care in the Older Woman with Primary Breast Cancer.

Cuba’s success in child health: what can one learn? (2019)
Journal Article

Delay in Source Control in Perforated Peptic Ulcer Leads to 6% Increased Risk of Death Per Hour: A Nationwide Cohort Study (2019)
Journal Article

© 2019, Société Internationale de Chirurgie. Background: Delay to theatre for patients with intra-abdominal sepsis is cited as a particular risk factor for death. Our aim was to evaluate the potential relationship between hourly delay from admission... Read More about Delay in Source Control in Perforated Peptic Ulcer Leads to 6% Increased Risk of Death Per Hour: A Nationwide Cohort Study.

Investigating ataxia in childhood (2019)
Journal Article

© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. Ataxia is a common presentation to an acute paediatric unit and it can often be difficult to determine the cause. It is important to distingu... Read More about Investigating ataxia in childhood.

First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis (2019)
Journal Article

BACKGROUND: Polycystic ovary syndrome (PCOS) is the most frequent cause of anovulatory infertility. In women with PCOS, effective ovulation induction serves as an important first-line treatment for anovulatory infertility. Individual participant data... Read More about First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis.

Expression of cholesterol packaging and transport genes in human and rat placenta: impact of obesity and a high-fat diet (2019)
Journal Article

Evidence suggests that sub-optimal maternal nutrition has implications for the developing offspring. We have previously shown that exposure to a low-protein diet during gestation was associated with upregulation of genes associated with cholesterol t... Read More about Expression of cholesterol packaging and transport genes in human and rat placenta: impact of obesity and a high-fat diet.

Rojiroti microfinance and child nutrition: a cluster randomised trial (2019)
Journal Article

Objective To determine whether Rojiroti microfinance, for poor Indian women, improves child nutrition. Design Cluster randomised trial. Setting Tolas (village communities) in Bihar State. Participants Women and children under 5 years. Int... Read More about Rojiroti microfinance and child nutrition: a cluster randomised trial.

What is geriatric rehabilitation and how should it be organized? A Delphi study aimed at reaching European consensus (2019)
Journal Article

© 2019, The Author(s). Purpose: Many European countries have developed services to rehabilitate the increasing number of older people who experience an acute or subacute decrease in function after a medical event such as a hip fracture or stroke. How... Read More about What is geriatric rehabilitation and how should it be organized? A Delphi study aimed at reaching European consensus.

Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage (2019)
Journal Article

Background and Purpose— Pilot trials suggest that glyceryl trinitrate (GTN; nitroglycerin) may improve outcome when administered early after stroke onset. Methods— We undertook a multicentre, paramedic-delivered, ambulance-based, prospective ran... Read More about Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage.

Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men (2019)
Journal Article

Background: The andropause is associated with declines in serum testosterone (T), loss of muscle mass (sarcopenia) and frailty. Two major interventions purported to offset sarcopenia are anabolic steroid therapies and resistance exercise training (RE... Read More about Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men.

Behavioural activation therapy for post-stroke depression: the BEADS feasibility RCT (2019)
Journal Article

Background: There is currently insufficient evidence for the clinical effectiveness and cost-effectiveness of psychological therapies for post-stroke depression. Objective: To evaluate the feasibility of undertaking a definitive trial to evaluate the... Read More about Behavioural activation therapy for post-stroke depression: the BEADS feasibility RCT.

Determinants of change in arterial stiffness over 5 years in early chronic kidney disease (2019)
Journal Article

Background Arterial stiffness is an established and potentially modifiable risk factor for cardiovascular disease, associated with chronic kidney disease. There have been few studies to evaluate progression of arterial stiffness over time or factors... Read More about Determinants of change in arterial stiffness over 5 years in early chronic kidney disease.

Pharmacological profile of vascular activity of human stem villous arteries (2019)
Journal Article

© 2019 Introduction: The function of the placental vasculature differs considerably from other systemic vascular beds of the human body. A detailed understanding of the normal placental vascular physiology is the foundation to understand perturbed co... Read More about Pharmacological profile of vascular activity of human stem villous arteries.