Skip to main content

Research Repository

Advanced Search

Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy

Luveta, Jocelyn; Parks, Ruth M.; Heery, David M.; Cheung, Kwok-Leung; Johnston, Simon J.

Invasive Lobular Breast Cancer as a Distinct Disease: Implications for Therapeutic Strategy Thumbnail


Authors

Jocelyn Luveta

Ruth M. Parks

Profile Image

DAVID HEERY david.heery@nottingham.ac.uk
Professor of Eucaryotic Gene Regulation

Simon J. Johnston



Abstract

Invasive lobular carcinoma comprises 10–15% of all breast cancers and is increasingly recognised as a distinct and understudied disease compared with the predominant histological subtype, invasive ductal carcinoma. Hallmarks of invasive lobular carcinoma include E-cadherin loss, leading to discohesive morphology with cells proliferating in single-file strands and oestrogen receptor positivity, with favourable response to endocrine therapy. This review summarises the distinct histological and molecular features of invasive lobular carcinoma with focus on diagnostic challenges and the impact on surgical management and medical therapy. Emphasis is placed on recent advances in our understanding of the unique molecular biology of lobular breast cancer and how this is optimising our therapy approach in the clinic.

Journal Article Type Article
Acceptance Date Dec 12, 2019
Online Publication Date Dec 24, 2019
Publication Date 2020-06
Deposit Date Jul 2, 2020
Publicly Available Date Jul 2, 2020
Journal Oncology and Therapy
Electronic ISSN 2366-1089
Peer Reviewed Peer Reviewed
Volume 8
Pages 1-11
DOI https://doi.org/10.1007/s40487-019-00105-0
Public URL https://nottingham-repository.worktribe.com/output/3683742
Publisher URL https://link.springer.com/article/10.1007%2Fs40487-019-00105-0

Files





You might also like



Downloadable Citations