All Outputs (77)

Risk factors and outcome differences in hypoglycaemia-related hospital admissions: A case-control study in England: ZACCARDIet al. (2017)
Journal Article
Zaccardi, F., Webb, D. R., Davies, M. J., Dhalwani, N. N., Housley, G., Shaw, D., …Khunti, K. (2017). Risk factors and outcome differences in hypoglycaemia-related hospital admissions: A case-control study in England: ZACCARDIet al. Diabetes, Obesity and Metabolism, 19(10), 1371-1378. https://doi.org/10.1111/dom.12941

Aims: To evaluate risk factors for hospital admissions for hypoglycaemia and compare length of hospitalization, inpatient mortality and hospital readmission between hypoglycaemia- and nonhypoglycaemia-related admissions. Materials and methods: We us... Read More about Risk factors and outcome differences in hypoglycaemia-related hospital admissions: A case-control study in England: ZACCARDIet al..

MMP-1 activation contributes to airway smooth muscle growth and asthma severity (2016)
Journal Article
Naveed, S., Clements, D., Jackson, D. J., Philp, C., Billington, C. K., Soomro, I. N., …Johnson, S. R. (2017). MMP-1 activation contributes to airway smooth muscle growth and asthma severity. American Journal of Respiratory and Critical Care Medicine, 195(8), 1000-1009. https://doi.org/10.1164/rccm.201604-0822OC

Introduction: Matrix metalloproteinase-1 and mast cells are present in the airways of people with asthma. We hypothesised that matrix metalloproteinase-1 could be activated by mast cells and increase asthma severity. Methods: Patients with stable ast... Read More about MMP-1 activation contributes to airway smooth muscle growth and asthma severity.

What are the pros and cons of electronically monitoring inhaler use in asthma? A multistakeholder perspective (2016)
Journal Article
Howard, S., Lang, A. R., Sharples, S., & Shaw, D. E. (in press). What are the pros and cons of electronically monitoring inhaler use in asthma? A multistakeholder perspective. BMJ Open Respiratory Research, 3(1), Article e000159. https://doi.org/10.1136/bmjresp-2016-000159

Introduction Electronic monitoring devices (EMDs) are the optimal method for collecting objective data on inhaler use in asthma. Recent research has investigated the attitudes of patients with asthma towards these devices. However, no research to... Read More about What are the pros and cons of electronically monitoring inhaler use in asthma? A multistakeholder perspective.

The role of histone arginine methylation in gene expression of airway smooth muscle cells in asthma (2016)
Journal Article
Kaczmarek, K., Clifford, R. L., Patel, J., Shaw, D., Dowden, J., & Knox, A. (2016). The role of histone arginine methylation in gene expression of airway smooth muscle cells in asthma. Thorax, 71(Suppl3), A214-A215. https://doi.org/10.1136/thoraxjnl-2016-209333.379

Introduction and objectives: Asthma is estimated to affect at least 300 million people globally. About 25% of the patients do not respond to therapy; therefore we need to develop novel treatments. ASM cells have a crucial role in asthma, contributing... Read More about The role of histone arginine methylation in gene expression of airway smooth muscle cells in asthma.

U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics (2016)
Journal Article
Lefaudeux, F., De Meulder, B., Loza, M. J., Peffer, N., Rowe, A., Baribaud, F., …Chung, K. F. (2017). U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics. Journal of Allergy and Clinical Immunology, 139(6), https://doi.org/10.1016/j.jaci.2016.08.048

Background: Asthma is a heterogeneous disease in which there is a differential response to asthma treatments. This heterogeneity needs to be evaluated so that a personalized management approach can be provided. Objectives: We stratified patients wit... Read More about U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics.

The differential effects of azithromycin on the airway epithelium in vitro and in vivo (2016)
Journal Article
Slater, M., Torr, E., Harrison, T. W., Forrester, D. L., Knox, A., Shaw, D. E., & Sayers, I. (2016). The differential effects of azithromycin on the airway epithelium in vitro and in vivo. Physiological Reports, 4(18), 1-15. https://doi.org/10.14814/phy2.12960

Macrolides including azithromycin (AZM) can improve clinical symptoms in asthma regardless of infection status. The mechanisms underlying these benefi- cial effects are yet to be elucidated. The aim of this study was to determine the effect of AZM on... Read More about The differential effects of azithromycin on the airway epithelium in vitro and in vivo.

Step 4: stick or twist? A review of asthma therapy (2016)
Journal Article
Slater, M. G., Pavord, I. D., & Shaw, D. E. (2016). Step 4: stick or twist? A review of asthma therapy. BMJ Open Respiratory Research, 3(1), 1-7. https://doi.org/10.1136/bmjresp-2016-000143

Many people with asthma do not achieve disease control, despite bronchodilators and inhaled corticosteroid therapy. People with uncontrolled asthma are at higher risk of an asthma attack and death, with mortality rates estimated at 1000 deaths/ year... Read More about Step 4: stick or twist? A review of asthma therapy.

A transcriptome-driven analysis of epithelial brushings and bronchial biopsies to define asthma phenotypes in U-BIOPRED (2016)
Journal Article
Khuo, C. S., Pavlidis, S., Loza, M., Baribaud, F., Rowe, A., Pandis, I., …Chung, K. F. (2017). A transcriptome-driven analysis of epithelial brushings and bronchial biopsies to define asthma phenotypes in U-BIOPRED. American Journal of Respiratory and Critical Care Medicine, 195(4), https://doi.org/10.1164/rccm.201512-2452OC

Rationale and objectives: Asthma is a heterogeneous disease driven by diverse immunologic and inflammatory mechanisms. We used transcriptomic profiling of airway tissues to help define asthma phenotypes. Methods: The transcriptome from bronchial biop... Read More about A transcriptome-driven analysis of epithelial brushings and bronchial biopsies to define asthma phenotypes in U-BIOPRED.

Evaluation of the PPAR-y agonist pioglitazone in mild asthma: A double-blind randomized controlled trial (2016)
Journal Article
Anderson, J., Mortimer, K., Pang, L., Smith, K., Bailey, H., Hodgson, D., …Harrison, T. W. (2016). Evaluation of the PPAR-y agonist pioglitazone in mild asthma: A double-blind randomized controlled trial. PLoS ONE, 11(8), 1-15. https://doi.org/10.1371/journal.pone.0160257

Background Peroxisome proliferator-activated receptor gamma (PPAR-γ) is a nuclear receptor that modulates inflammation in models of asthma. To determine whether pioglitazone improves measures of asthma control and airway inflammation, we performed... Read More about Evaluation of the PPAR-y agonist pioglitazone in mild asthma: A double-blind randomized controlled trial.

Expression of polycomb protein BMI-1 1 maintains the plasticity of basal 2 bronchial epithelial cells (2016)
Journal Article
Torr, E., Heath, M., Mee, M., Shaw, D. E., Sharp, T. V., & Sayers, I. (2016). Expression of polycomb protein BMI-1 1 maintains the plasticity of basal 2 bronchial epithelial cells. Physiological Reports, 4(16), 1-14. https://doi.org/10.14814/phy2.12847

The airway epithelium is altered in respiratory disease and is thought to contribute to disease aetiology. A caveat to disease research is that the technique of isolation of bronchial epithelial cells from patients is invasive and cells have a limite... Read More about Expression of polycomb protein BMI-1 1 maintains the plasticity of basal 2 bronchial epithelial cells.

A prebiotic galactooligosaccharide mixture reduces severity of hyperpnoea-induced bronchoconstriction and markers of airway inflammation (2016)
Journal Article
Williams, N. C., Johnson, M. A., Shaw, D. E., Spendlove, I., Vulevic, J., Sharpe, G. R., & Hunter, K. A. (2016). A prebiotic galactooligosaccharide mixture reduces severity of hyperpnoea-induced bronchoconstriction and markers of airway inflammation. British Journal of Nutrition, 116(5), 798-804. https://doi.org/10.1017/S0007114516002762

Gut microbes have a substantial influence on systemic immune function and allergic sensitisation. Manipulation of the gut microbiome through prebiotics may provide a potential strategy to influence the immunopathology of asthma. This study investigat... Read More about A prebiotic galactooligosaccharide mixture reduces severity of hyperpnoea-induced bronchoconstriction and markers of airway inflammation.

See I told you I was taking it! - attitudes of adolescents with asthma towards a device monitoring their inhaler use: Implications for future design (2016)
Journal Article
Howard, S., Lang, A. R., Sharples, S., & Shaw, D. E. (2017). See I told you I was taking it! - attitudes of adolescents with asthma towards a device monitoring their inhaler use: Implications for future design. Applied Ergonomics, 58, 224-237. https://doi.org/10.1016/j.apergo.2016.06.018

Adherence to treatment in asthma is often poor, particularly in adolescents and children where the condition is most prevalent. Electronic monitoring devices have shown potential for improving inhaler use, yet little research has considered the attit... Read More about See I told you I was taking it! - attitudes of adolescents with asthma towards a device monitoring their inhaler use: Implications for future design.

Untargeted metabolic profiling of saliva by liquid chromatography-mass spectrometry for the identification of potential diagnostic biomarkers of asthma (2016)
Journal Article
Malkar, A., Wilson, E., Harrison, T., Shaw, D. E., & Creaser, C. (in press). Untargeted metabolic profiling of saliva by liquid chromatography-mass spectrometry for the identification of potential diagnostic biomarkers of asthma. Analytical Methods, 8(27), 5407-5413. https://doi.org/10.1039/C6AY00938G

Current clinical tests employed to diagnose asthma are inaccurate and limited by their invasive nature. New metabolite profiling technologies offer an opportunity to improve asthma diagnosis using non-invasive sampling. A rapid analytical method for... Read More about Untargeted metabolic profiling of saliva by liquid chromatography-mass spectrometry for the identification of potential diagnostic biomarkers of asthma.

Trends in hospital admissions for hypoglycaemia in England: a retrospective, observational study (2016)
Journal Article
Zaccardi, F., Davies, M. J., Dhalwani, N. N., Webb, D. R., Housley, G., Shaw, D. E., …Khunti, K. (2016). Trends in hospital admissions for hypoglycaemia in England: a retrospective, observational study. Lancet Diabetes and Endocrinology, 4(8), 677-685. https://doi.org/10.1016/S2213-8587%2816%2930091-2

Background Studies in the USA and Canada have reported increasing or stable rates of hospital admissions for hypoglycaemia. Some data from small studies are available for other countries. We aimed to gather information about long-term trends in ho... Read More about Trends in hospital admissions for hypoglycaemia in England: a retrospective, observational study.

Effect of smoking status on the efficacy of the SMART regimen in high risk asthma (2016)
Journal Article
Pilcher, J., Patel, M., Reddel, H. K., Pritchard, A., Black, P., Shaw, D., …Beasley, R. (2016). Effect of smoking status on the efficacy of the SMART regimen in high risk asthma. Respirology, 21(5), 858-866. https://doi.org/10.1111/resp.12740

Background and objective: The optimal management of people with asthma with a significant smoking history is uncertain. The aim of this study was to determine whether the efficacy/safety profile of single combination inhaled corticosteroid (ICS)/long... Read More about Effect of smoking status on the efficacy of the SMART regimen in high risk asthma.

The challenge of measuring IL-33 in serum using commercial ELISA: lessons from asthma (2016)
Journal Article
Ketelaar, M. E., Nawijn, M. C., Shaw, D. E., Koppelman, G. H., & Sayers, I. (2016). The challenge of measuring IL-33 in serum using commercial ELISA: lessons from asthma. Clinical and Experimental Allergy, 46(6), 884-887. https://doi.org/10.1111/cea.12718

Background Interleukin-33 (IL-33) has been subject of extensive study in the context of inflammatory disorders, particularly in asthma. Many human biological samples, including serum, have been used to determine the protein levels of IL-33, aiming t... Read More about The challenge of measuring IL-33 in serum using commercial ELISA: lessons from asthma.

Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study (2015)
Journal Article
McKeever, T. M., Hearson, G., Housley, G., Reynolds, C., Kinnear, W., Harrison, T. W., …Shaw, D. E. (2016). Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study. Thorax, 71(3), 210-215. https://doi.org/10.1136/thoraxjnl-2015-207573

Introduction: Identifying acute hypercapnic respiratory failure is crucial in the initial management of acute exacerbations of COPD. Guidelines recommend obtaining arterial blood samples but these are more difficult to obtain than venous. We assessed... Read More about Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study.

Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma (2015)
Journal Article
Lilburn, D. M., Tatler, A. L., Six, J. S., Lesbats, C., Habgood, A., Porte, J., …Meersmann, T. (2015). Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma. Magnetic Resonance in Medicine, 76(4), 1224-1235. https://doi.org/10.1002/mrm.26003

© 2015 The Authors. Wiley Periodicals, Inc. Purpose: Asthma is a disease of increasing worldwide importance that calls for new investigative methods. Ex vivo lung tissue is being increasingly used to study functional respiratory parameters independen... Read More about Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma.

Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort (2015)
Journal Article
Shaw, D. E., Sousa, A. R., Fowler, S. J., Fleming, L. J., Roberts, G., Corfield, J., …Chung, K. F. (2015). Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. European Respiratory Journal, 46(5), 1308-1321. https://doi.org/10.1183/13993003.00779-2015

U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach. This c... Read More about Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort.

Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema (2015)
Journal Article
Lilburn, D. M., Lesbats, C., Six, J. S., Dubuis, E., Yew-Booth, L., Shaw, D. E., …Meersmann, T. (2015). Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema. Interface, 12(107), Article 20150192. https://doi.org/10.1098/rsif.2015.0192

© 2015 The Authors. Hyperpolarized 83Kr surface quadrupolar relaxation (SQUARE) generates MRI contrast that was previously shown to correlate with surface-to-volume ratios in porous model surface systems. The underlying physics of SQUARE contrast is... Read More about Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema.