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Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

Shaw, Dominick E.; Sousa, Ana R.; Fowler, Stephen J.; Fleming, Louise J.; Roberts, Graham; Corfield, Julie; Pandis, Ioannis; Bansal, Aruna T.; Bel, Elisabeth H.; Auffray, Charles; Compton, Chris H.; Bisgaard, Hans; Bucchioni, Enrica; Caruso, Massimo; Chanez, Pascal; Dahlen, Barbro; Dahlen, Sven-Erik; Dyson, Kerry; Frey, Urs; Geiser, Thomas; Gerhardsson de Verdier, Maria; Gibeon, David; Guo, Yi-ke; Hashimoto, Simone; Hedlin, Gunilla; Jeyasingham, Elizabeth; Hekking, Pieter-Paul W.; Higenbottam, Tim; Horváth, Ildikó; Knox, Alan J.; Krug, Norbert; Erpenbeck, Veit J.; Larsson, Lars X.; Lazarinis, Nikos; Matthews, John G.; Middelveld, Roelinde; Montuschi, Paolo; Musial, Jacek; Myles, David; Pahus, Laurie; Sandström, Thomas; Seibold, Wolfgang; Singer, Florian; Strandberg, Karin; Vestbo, Jorgen; Vissing, Nadja; von Garnier, Christophe; Adcock, Ian M.; Wagers, Scott; Rowe, Anthony; Howarth, Peter; Wagener, Ariane H.; Djukanovic, Ratko; Sterk, Peter J.; Chung, Kian Fan

Authors

Ana R. Sousa

Stephen J. Fowler

Louise J. Fleming

Graham Roberts

Julie Corfield

Ioannis Pandis

Aruna T. Bansal

Elisabeth H. Bel

Charles Auffray

Chris H. Compton

Hans Bisgaard

Enrica Bucchioni

Massimo Caruso

Pascal Chanez

Barbro Dahlen

Sven-Erik Dahlen

Kerry Dyson

Urs Frey

Thomas Geiser

Maria Gerhardsson de Verdier

David Gibeon

Yi-ke Guo

Simone Hashimoto

Gunilla Hedlin

Elizabeth Jeyasingham

Pieter-Paul W. Hekking

Tim Higenbottam

Ildikó Horváth

Alan J. Knox

Norbert Krug

Veit J. Erpenbeck

Lars X. Larsson

Nikos Lazarinis

John G. Matthews

Roelinde Middelveld

Paolo Montuschi

Jacek Musial

David Myles

Laurie Pahus

Thomas Sandström

Wolfgang Seibold

Florian Singer

Karin Strandberg

Jorgen Vestbo

Nadja Vissing

Christophe von Garnier

Ian M. Adcock

Scott Wagers

Anthony Rowe

Peter Howarth

Ariane H. Wagener

Ratko Djukanovic

Peter J. Sterk

Kian Fan Chung



Abstract

U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach.

This cross-sectional assessment of adults with severe asthma, mild/moderate asthma and healthy controls from 11 European countries consisted of analyses of patient-reported outcomes, lung function, blood and airway inflammatory measurements.

Patients with severe asthma (nonsmokers, n=311; smokers/ex-smokers, n=110) had more symptoms and exacerbations compared to patients with mild/moderate disease (n=88) (2.5 exacerbations versus 0.4 in the preceding 12 months; p

Journal Article Type Article
Publication Date Sep 10, 2015
Journal European Respiratory Journal
Print ISSN 0903-1936
Electronic ISSN 1399-3003
Publisher European Respiratory Society
Peer Reviewed Peer Reviewed
Volume 46
Issue 5
Pages 1308-1321
APA6 Citation Dahlén, B., Shaw, D. E., Sousa, A. R., Fowler, S. J., Fleming, L. J., Roberts, G., …Chung, K. F. (2015). Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. European Respiratory Journal, 46(5), 1308-1321. https://doi.org/10.1183/13993003.00779-2015
DOI https://doi.org/10.1183/13993003.00779-2015
Keywords Pulmonary and Respiratory Medicine
Publisher URL http://erj.ersjournals.com/content/46/5/1308
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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