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Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema

Lilburn, David M.L.; Lesbats, Cl�mentine; Six, Joseph S.; Dubuis, Eric; Yew-Booth, Liang; Shaw, Dominick E.; Belvisi, Maria G.; Birrell, Mark A.; Pavlovskaya, Galina E.; Meersmann, Thomas

Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema Thumbnail


Authors

David M.L. Lilburn

Cl�mentine Lesbats

Joseph S. Six

Eric Dubuis

Liang Yew-Booth

Dominick E. Shaw

Maria G. Belvisi

Mark A. Birrell

THOMAS MEERSMANN thomas.meersmann@nottingham.ac.uk
Professor of Translational Imaging



Abstract

© 2015 The Authors. Hyperpolarized 83Kr surface quadrupolar relaxation (SQUARE) generates MRI contrast that was previously shown to correlate with surface-to-volume ratios in porous model surface systems. The underlying physics of SQUARE contrast is conceptually different from any other current MRI methodology as the method uses the nuclear electric properties of the spin I = 9/2 isotope 83Kr. To explore the usage of this non-radioactive isotope for pulmonary pathophysiology, MRI SQUARE contrast was acquired in excised rat lungs obtained from an elastase-induced model of emphysema. A significant 83Kr T1 relaxation time increase in the SQUARE contrast was found in the elastase-treated lungs compared with the baseline data from control lungs. The SQUARE contrast suggests a reduction in pulmonary surface-to-volume ratio in the emphysema model that was validated by histology. The finding supports usage of83 Kr SQUARE as a new biomarker for surface-to-volume ratio changes in emphysema.

Citation

Lilburn, D. M., Lesbats, C., Six, J. S., Dubuis, E., Yew-Booth, L., Shaw, D. E., …Meersmann, T. (2015). Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema. Interface, 12(107), Article 20150192. https://doi.org/10.1098/rsif.2015.0192

Journal Article Type Article
Acceptance Date Apr 27, 2015
Publication Date Jun 6, 2015
Deposit Date Feb 8, 2016
Publicly Available Date Mar 28, 2024
Journal Journal of the Royal Society Interface
Electronic ISSN 1742-5662
Publisher The Royal Society
Peer Reviewed Peer Reviewed
Volume 12
Issue 107
Article Number 20150192
DOI https://doi.org/10.1098/rsif.2015.0192
Keywords krypton-83; hyperpolarized noble gas MRI; pulmonary imaging; surface sensitive contrast; animal model emphysema; nuclear electric quadrupolar relaxation
Public URL https://nottingham-repository.worktribe.com/output/751883
Publisher URL http://rsif.royalsocietypublishing.org/content/12/107/20150192
Related Public URLs http://rsif.royalsocietypublishing.org/
Additional Information Lilburn DML et al. 2015 Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model
of emphysema. J. R. Soc. Interface 12, 107: 20150192.
http://dx.doi.org/10.1098/rsif.2015.0192

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