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Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema

Lilburn, David M.L.; Lesbats, Clémentine; Six, Joseph S.; Dubuis, Eric; Yew-Booth, Liang; Shaw, Dominick E.; Belvisi, Maria G.; Birrell, Mark A.; Pavlovskaya, Galina E.; Meersmann, Thomas

Authors

David M.L. Lilburn

Clémentine Lesbats

Joseph S. Six

Eric Dubuis

Liang Yew-Booth

Maria G. Belvisi

Mark A. Birrell



Abstract

Hyperpolarized 83Kr surface quadrupolar relaxation (SQUARE) generates MRI contrast that was previously shown to correlate to surface to volume ratios in porous model surface systems. The underlying physics of SQUARE contrast is conceptually different from any other current MRI methodology as the method utilizes the nuclear electric properties of the spin I = 9/2 isotope 83Kr. To explore the usage of this non-radioactive isotope for pulmonary pathophysiology, MRI SQUARE contrast was acquired in excised rat lungs obtained from an elastase induced model of emphysema. A significant 83Kr T1 relaxation time increase in the SQUARE contrast was found in the elastase treated lungs compared to the baseline data from control lungs. The SQUARE contrast suggests a reduction in pulmonary surface to volume ratio in the emphysema model that was validated by histology. The finding supports usage of 83Kr SQUARE as new biomarker for surface to volume ratio changes in emphysema.

Journal Article Type Article
Publication Date May 20, 2015
Journal Interface
Electronic ISSN 1742-5689
Publisher Royal Society, The
Peer Reviewed Peer Reviewed
Volume 12
Issue 107
Article Number 20150192
APA6 Citation Lilburn, D. M., Lesbats, C., Six, J. S., Dubuis, E., Yew-Booth, L., Shaw, D. E., …Meersmann, T. (2015). Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema. Interface, 12(107), doi:10.1098/rsif.2015.0192
DOI https://doi.org/10.1098/rsif.2015.0192
Keywords krypton-83; hyperpolarized noble gas MRI; pulmonary imaging; surface sensitive contrast; animal model emphysema; nuclear electric quadrupolar relaxation
Publisher URL http://rsif.royalsocietypublishing.org/content/12/107/20150192
Related Public URLs http://rsif.royalsocietypublishing.org/
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information Lilburn DML et al. 2015 Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model
of emphysema. J. R. Soc. Interface 12, 107: 20150192.
http://dx.doi.org/10.1098/rsif.2015.0192

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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