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Surface polymer imprinted optical fibre sensor for dose detection of dabrafenib (2020)
Journal Article
He, C., Ledezma, U. H., Gurnani, P., Albelha, T., Thurecht, K. J., Correia, R., …Korposh, S. (2020). Surface polymer imprinted optical fibre sensor for dose detection of dabrafenib. Analyst, 145(13), 4504-4511. https://doi.org/10.1039/d0an00434k

© 2020 The Royal Society of Chemistry. Dabrafenib is one of the most widely used of the new generation of targeted anti-cancer drugs. However, its therapeutic window varies for different patients and so there is an unmet need for methods to monitor t... Read More about Surface polymer imprinted optical fibre sensor for dose detection of dabrafenib.

The prognostic significance of ALDH1A1 expression in early invasive breast cancer (2020)
Journal Article
Althobiti, M., El Ansari, R., Aleskandarany, M., Joseph, C., Toss, M. S., Green, A. R., & Rakha, E. A. (2020). The prognostic significance of ALDH1A1 expression in early invasive breast cancer. Histopathology, 77(3), 437-448. https://doi.org/10.1111/his.14129

Aims: Aldehyde dehydrogenase family 1 member A1 (ALDH1A1)is reportedly a key ALDH isozyme linked to the cancer stem cells (CSC) of many solid tumours, where it is involved in self-renewal, differentiation and self-protection. In this study, the progn... Read More about The prognostic significance of ALDH1A1 expression in early invasive breast cancer.

Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer (2020)
Journal Article
Monteiro, P. F., Gulfam, M., Monteiro, C. J., Travanut, A., Abelha, T. F., Pearce, A. K., …Alexander, C. (2020). Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer. Journal of Controlled Release, 323, 549-564. https://doi.org/10.1016/j.jconrel.2020.04.049

© 2020 Elsevier B.V. Triple negative or basal-like breast cancer (TNBC) is characterised by aggressive progression, lack of standard therapies and poorer overall survival rates for patients. The bad prognosis, high rate of relapse and resistance agai... Read More about Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer.

The relationship between ECOG-PS, mGPS, BMI/WL grade and body composition and physical function in patients with advanced cancer (2020)
Journal Article
Fallon, M., Dolan, R. D., Daly, L. E., Simmons, C. P. L., Wilcock, A., Usborne, C., …Maddocks, M. (2020). The relationship between ECOG-PS, mGPS, BMI/WL grade and body composition and physical function in patients with advanced cancer. Cancers, 12(5), Article 1187. https://doi.org/10.3390/cancers12051187

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Cancer remains one of the leading causes of mortality worldwide and the associated reduction in physical function has a marked impact on both quality of life and survival. The aim of the prese... Read More about The relationship between ECOG-PS, mGPS, BMI/WL grade and body composition and physical function in patients with advanced cancer.

Retrospective assessment of cyclin?dependent kinase 5 mRNA and protein expression and its association with patient survival in breast cancer (2020)
Journal Article
Saidy, B., Rakha, E. A., Green, A. R., Ellis, I. O., Martin, S. G., & Storr, S. J. (2020). Retrospective assessment of cyclin?dependent kinase 5 mRNA and protein expression and its association with patient survival in breast cancer. Journal of Cellular and Molecular Medicine, 24(11), 6263-6271. https://doi.org/10.1111/jcmm.15268

Cyclin?dependent kinase 5 (Cdk5) is an atypical member of the cyclin?dependent kinase family and functions as a serine/threonine kinase that can be activated by non?cyclin binding activators p35 or p39. Cdk5 expression and activity has been linked wi... Read More about Retrospective assessment of cyclin?dependent kinase 5 mRNA and protein expression and its association with patient survival in breast cancer.

Myxovirus resistance 1 (MX1) is an independent predictor of poor outcome in invasive breast cancer (2020)
Journal Article
Aljohani, A. I., Joseph, C., Kurozumi, S., Mohammed, O. J., Miligy, I. M., Green, A. R., & Rakha, E. (2020). Myxovirus resistance 1 (MX1) is an independent predictor of poor outcome in invasive breast cancer. Breast Cancer Research and Treatment, 181(3), 541-551. https://doi.org/10.1007/s10549-020-05646-x

Background: Breast cancer (BC) is a disease with variable morphology, clinical behaviour and response to therapy. Identifying factors associated with the progression of early stage BC can help understand the risk of metastasis and guide treatment dec... Read More about Myxovirus resistance 1 (MX1) is an independent predictor of poor outcome in invasive breast cancer.

Mathematical model to determine the effect of a sub-glycocalyx space (2020)
Journal Article
Dyson, R. J., Dalwadi, M. P., Dalwadi, M. P., King, J. R., Dyson, R. J., & Arkill, K. P. (2020). Mathematical model to determine the effect of a sub-glycocalyx space. Physical Review Fluids, 5(4), https://doi.org/10.1103/physrevfluids.5.043103

We consider the drainage of blood plasma across the capillary wall, focusing on the flow through the endothelial glycocalyx layer that coats the luminal surface of vascular endothelial cells. We investigate how the presence of a sub-glycocalyx space... Read More about Mathematical model to determine the effect of a sub-glycocalyx space.

SPAG5: An Emerging Oncogene (2020)
Journal Article
He, J., Green, A. R., Li, Y., Chan, S. Y. T., & Liu, D. (2020). SPAG5: An Emerging Oncogene. Trends in Cancer, 6(7), 543-547. https://doi.org/10.1016/j.trecan.2020.03.006

SPAG5 is a mitotic spindle protein. Recent studies have found that it is overexpressed in many human cancers and functions as an oncogene. We summarize the current underlying mechanisms for its oncogenic roles in regulating cellular behaviors of canc... Read More about SPAG5: An Emerging Oncogene.

Regional differences in human biliary tissues and corresponding in vitro derived organoids (2020)
Journal Article
Rimland, C. A., Tilson, S. G., Morell, C. M., Tomaz, R. A., Lu, W., Adams, S. E., …Vallier, L. (2021). Regional differences in human biliary tissues and corresponding in vitro derived organoids. Hepatology, 73(1), 247-267. https://doi.org/10.1002/hep.31252

Background Organoids provide a powerful system to study epithelia in vitro . Recently, this approach was applied successfully to the biliary tree, a series of ductular tissues responsible for the drainage of bile and pancreatic secretions. More prec... Read More about Regional differences in human biliary tissues and corresponding in vitro derived organoids.

The solute carrier SLC7A8 is a marker of favourable prognosis in ER-positive low proliferative invasive breast cancer (2020)
Journal Article
Ansari, R., Craze, M. L., Alfarsi, L., Masisi, B. K., Ellis, I. O., Rakha, E. A., & Green, A. R. (2020). The solute carrier SLC7A8 is a marker of favourable prognosis in ER-positive low proliferative invasive breast cancer. Breast Cancer Research and Treatment, 181(1), 1-12. https://doi.org/10.1007/s10549-020-05586-6

Purpose: Breast cancer (BC) is a heterogeneous disease consisting of various subtypes, with different prognostic and therapeutic outcomes. The amino acid transporter, SLC7A8, is over expressed in estrogen receptor positive BC. However the consequenc... Read More about The solute carrier SLC7A8 is a marker of favourable prognosis in ER-positive low proliferative invasive breast cancer.

Cytoplasmic cyclin E is an independent marker of aggressive tumor biology and breast cancer-specific mortality in women over 70 years of age (2020)
Journal Article
Johnston, S. J., Syed, B. M., Parks, R. M., Monteiro, C. J., Caruso, J. A., Green, A. R., …Cheung, K. L. (2020). Cytoplasmic cyclin E is an independent marker of aggressive tumor biology and breast cancer-specific mortality in women over 70 years of age. Cancers, 12(3), Article 712. https://doi.org/10.3390/cancers12030712

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Multi-cohort analysis demonstrated that cytoplasmic cyclin E expression in primary breast tumors predicts aggressive disease. However, compared to their younger counterparts, older patients ha... Read More about Cytoplasmic cyclin E is an independent marker of aggressive tumor biology and breast cancer-specific mortality in women over 70 years of age.

The prognostic significance of immune microenvironment in breast ductal carcinoma in situ (2020)
Journal Article
Toss, M. S., Abidi, A., Lesche, D., Joseph, C., Mahale, S., Saunders, H., …Rakha, E. A. (2020). The prognostic significance of immune microenvironment in breast ductal carcinoma in situ. British Journal of Cancer, 122, 1496–1506. https://doi.org/10.1038/s41416-020-0797-7

Background The role of different subtypes of tumour infiltrating lymphocytes (TILs) in breast ductal carcinoma in situ (DCIS) is still poorly defined. This study aimed to assess the prognostic significance of B and T lymphocytes and immune checkpo... Read More about The prognostic significance of immune microenvironment in breast ductal carcinoma in situ.

Presence of donor-encoded centromeric KIR B content increases the risk of infectious mortality in recipients of myeloablative, T-cell deplete, HLA-matched HCT to treat AML (2020)
Journal Article
Potter, M. N., Wilson, M. C., Pearce, R. M., Lee, J., Garcia-Sepulveda, C. A., Bloor, A. J., …Byrne, J. L. (2020). Presence of donor-encoded centromeric KIR B content increases the risk of infectious mortality in recipients of myeloablative, T-cell deplete, HLA-matched HCT to treat AML. Bone Marrow Transplantation, 55, 1975–1984. https://doi.org/10.1038/s41409-020-0858-9

The reported influence of donor Killer-cell Immunoglobulin-like Receptor (KIR) genes on the outcomes of haematopoietic cell transplantation (HCT) are contradictory, in part due to diversity of disease, donor sources, era and conditioning regimens wit... Read More about Presence of donor-encoded centromeric KIR B content increases the risk of infectious mortality in recipients of myeloablative, T-cell deplete, HLA-matched HCT to treat AML.

The genetic architecture of breast papillary lesions as a predictor of progression to carcinoma (2020)
Journal Article
Thio, N., Kader, T., Elder, K., Zethoven, M., Semple, T., Hill, P., …Gorringe, K. L. (2020). The genetic architecture of breast papillary lesions as a predictor of progression to carcinoma. npj Breast Cancer, 6, Article 9. https://doi.org/10.1038/s41523-020-0150-6

Intra-ductal papillomas (IDP) are challenging breast findings because of their variable risk of progression to malignancy. The molecular events driving IDP development and genomic features of malignant progression are poorly understood. In this study... Read More about The genetic architecture of breast papillary lesions as a predictor of progression to carcinoma.

PIK3C? expression by fibroblasts promotes triple-negative breast cancer progression (2020)
Journal Article
Huang, P., Gagliano, T., Shah, K., Gargani, S., Lao, L., Alsaleem, M., …Giamas, G. (2020). PIK3Cδ expression by fibroblasts promotes triple-negative breast cancer progression. Journal of Clinical Investigation, 130(6), 3188-3204. https://doi.org/10.1172/jci128313

As there is growing evidence for the tumor microenvironment’s (TME) role in tumorigenesis, we investigated the role of fibroblast-expressed kinases in triple negative breast cancer (TNBC). Using a high-throughput kinome screen combined with 3D invasi... Read More about PIK3C? expression by fibroblasts promotes triple-negative breast cancer progression.

The UK NCRI study of chlorambucil, mitoxantrone and dexamethasone (CMD) versus fludarabine, mitoxantrone and dexamethasone (FMD) for untreated advanced stage follicular lymphoma: molecular response strongly predicts prolonged overall survival (2020)
Journal Article
Bishton, M. J., Rule, S., Wilson, W., Turner, D., Patmore, R., Clifton‐Hadley, L., …Haynes, A. (2020). The UK NCRI study of chlorambucil, mitoxantrone and dexamethasone (CMD) versus fludarabine, mitoxantrone and dexamethasone (FMD) for untreated advanced stage follicular lymphoma: molecular response strongly predicts prolonged overall survival. British Journal of Haematology, 190(4), 545-554. https://doi.org/10.1111/bjh.16555

We present a long-term follow-up of the UK chlorambucil, mitoxantrone and dexamethasone (CMD) versus fludarabine, mitoxantrone and dexamethasone (FMD) for untreated advanced, symptomatic follicular lymphoma (FL). This trial was the first to prospecti... Read More about The UK NCRI study of chlorambucil, mitoxantrone and dexamethasone (CMD) versus fludarabine, mitoxantrone and dexamethasone (FMD) for untreated advanced stage follicular lymphoma: molecular response strongly predicts prolonged overall survival.

Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers (2020)
Journal Article
Janssen, E. A., Ogden, A., Bhattarai, S., Sahoo, B., Mongan, N. P., Alsaleem, M., …Aneja, R. (2020). Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers. Scientific Reports, 10(1), Article 3009. https://doi.org/10.1038/s41598-020-59514-1

© 2020, The Author(s). Epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 3 (HER3) have been investigated as triple-negative breast cancer (TNBC) biomarkers. Reduced EGFR levels can be compensated by increases in HER3;... Read More about Combined HER3-EGFR score in triple-negative breast cancer provides prognostic and predictive significance superior to individual biomarkers.

Blood platelets stimulate cancer extravasation through TGFβ-mediated downregulation of PRH/HHEX (2020)
Journal Article
Marcolino De Assis, E., Siddiqui, Y. H., van den Bosch, M., Poole, A. W., Jayaraman, P., & Gaston, K. (2020). Blood platelets stimulate cancer extravasation through TGFβ-mediated downregulation of PRH/HHEX. Oncogenesis, 9, Article 10. https://doi.org/10.1038/s41389-020-0189-0

Cancer cells go through a process known as epithelial–mesenchymal transition (EMT) during which they acquire the ability to migrate and invade extracellular matrix. Some cells also acquire the ability to move across a layer of endothelial cells to en... Read More about Blood platelets stimulate cancer extravasation through TGFβ-mediated downregulation of PRH/HHEX.

Co-Expression Effect of SLC7A5/SLC3A2 to Predict Response to Endocrine Therapy in Oestrogen-Receptor-Positive Breast Cancer (2020)
Journal Article
Alfarsi, L. H., El-Ansari, R., Craze, M. L., Masisi, B. K., Mohammed, O. J., Rakha, E. A., …Green, A. R. (2020). Co-Expression Effect of SLC7A5/SLC3A2 to Predict Response to Endocrine Therapy in Oestrogen-Receptor-Positive Breast Cancer. International Journal of Molecular Sciences, 21(4), Article 1407. https://doi.org/10.3390/ijms21041407

The majority of breast cancers are oestrogen receptor positive (ER+) and are subject to endocrine therapy however, an unpredictable subgroup of patients will develop resistance to endocrine therapy. SLC7A5/SLC3A2 complex is a major route for the tran... Read More about Co-Expression Effect of SLC7A5/SLC3A2 to Predict Response to Endocrine Therapy in Oestrogen-Receptor-Positive Breast Cancer.