SPAG5: An Emerging Oncogene

He, Ji; Green, Andrew R; Li, Yan; Chan, Stephen Y T; Liu, Dong-Xu

Abstract

SPAG5 is a mitotic spindle protein. Recent studies have found that it is overexpressed in many human cancers and functions as an oncogene. We summarize the current underlying mechanisms for its oncogenic roles in regulating cellular behaviors of cancer cells and discuss the possibility to target SPAG5 for cancer treatment. SPAG5 in human cancers Sperm associated antigen 5 (SPAG5, also called astrin) is a mitotic spindle protein. In normal cells, it ensures a correct separation of sister chromatids into daughter cells. SPAG5 depletion induces a spindle checkpoint arrest characteristic of the formation of multipolar spindles and a loss of sister chromatid cohesion [1]. However, SPAG5 gene gains and amplifications are observed in many cancers (Table 1). Increased SPAG5 expression is correlated with poor clinical outcomes and adverse clinicopathological features in breast cancer [2]. In several cancer models, SPAG5 is implicated in neoplastic growth, chemoresistance, metastasis, local recurrence and overall survival, whereas its downregulation results in suppressed cell

Citation

He, J., Green, A. R., Li, Y., Chan, S. Y. T., & Liu, D. (2020). SPAG5: An Emerging Oncogene. Trends in Cancer, 6(7), 543-547. https://doi.org/10.1016/j.trecan.2020.03.006

• Journal Article Type: Review
• Acceptance Date: Mar 19, 2020
• Online Publication Date: Apr 11, 2020
• Publication Date: 2020-07
• Deposit Date: Mar 20, 2020
• Publicly Available Date: Apr 12, 2021
• Journal: Trends in Cancer
• Publisher: Elsevier (Cell Press)
• Peer Reviewed: Peer Reviewed
• Volume: 6
• Issue: 7
• Pages: 543-547
• DOI: https://doi.org/10.1016/j.trecan.2020.03.006
• Keywords: SPAG5; astrin; oncogene; gene amplification; therapeutic target; cancer therapy
• Public URL: https://nottingham-repository.worktribe.com/output/4173759
• Publisher URL: https://www.sciencedirect.com/science/article/abs/pii/S2405803320301072