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Surface polymer imprinted optical fibre sensor for dose detection of dabrafenib

He, Chenyang; Ledezma, Ulises Hernandez; Gurnani, Pratik; Albelha, Thais; Thurecht, Kristofer J.; Correia, Ricardo; Morgan, Stephen P.; Patel, Poulam; Alexander, Cameron; Korposh, Sergiy

Surface polymer imprinted optical fibre sensor for dose detection of dabrafenib Thumbnail


Authors

Chenyang He

Ulises Hernandez Ledezma

Pratik Gurnani

Thais Albelha

Kristofer J. Thurecht

POULAM PATEL POULAM.PATEL@NOTTINGHAM.AC.UK
Professor of Clinical Oncology

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SERHIY KORPOSH S.Korposh@nottingham.ac.uk
Professor of Photonics Instrumentation



Abstract

© 2020 The Royal Society of Chemistry. Dabrafenib is one of the most widely used of the new generation of targeted anti-cancer drugs. However, its therapeutic window varies for different patients and so there is an unmet need for methods to monitor the dose of drug which the patient receives and at the specific site where it acts. In the case of cancers, it is critical to measure the concentration of drug not just in the bloodstream overall, but in or near tumours, as these will not be the same over multiple time periods. A novel sensor based on an optical fibre long period grating (LPG) modified with a molecular imprinted polymer (MIP) has been developed with the ultimate aim of achieving minimally invasive measurements of Dabrafenib at the tumour site. A molecularly imprinted polymer specific for Dabrafenib was coated on a methacryloylalkoxysilane-functionalised optical fibre long period grating. In vitro experimental results demonstrate that the Dabrafenib sensitivity is 15.2 pm (μg mL-1)-1 (R2 = 0.993) with a limit of detection (LoD) of 74.4 μg mL-1 in serum solution. Moreover, the proposed sensor shows selective response to Dabrafenib over structurally similar 2-Aminoquinoline.

Journal Article Type Article
Acceptance Date May 6, 2020
Online Publication Date May 7, 2020
Publication Date Jul 7, 2020
Deposit Date Sep 4, 2020
Publicly Available Date May 8, 2021
Journal Analyst
Print ISSN 0003-2654
Electronic ISSN 1364-5528
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 145
Issue 13
Pages 4504-4511
DOI https://doi.org/10.1039/d0an00434k
Keywords Analytical Chemistry; Spectroscopy; Electrochemistry; Biochemistry; Environmental Chemistry
Public URL https://nottingham-repository.worktribe.com/output/4442482
Publisher URL https://pubs.rsc.org/en/content/articlelanding/2020/AN/D0AN00434K#!divAbstract
Additional Information : This document is Similarity Check deposited; : Chenyang He (ORCID); : Thais Albelha (ORCID); : Kristofer J. Thurecht (ORCID); : Kristofer J. Thurecht (ResearcherID); : Sergiy Korposh (ORCID); : Single-blind; : Received 3 March 2020; Accepted 6 May 2020; Accepted Manuscript published 7 May 2020; Advance Article published 15 May 2020

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