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The relationship between ECOG-PS, mGPS, BMI/WL grade and body composition and physical function in patients with advanced cancer

Fallon, Marie; Dolan, Ross D.; Daly, Louise E.; Simmons, Claribel P. L.; Wilcock, Andrew; Usborne, Caroline; Bennett, Michael I.; Ryan, Aoife M.; Sim, Wei M. J.; Power, Derek G.; Laird, Barry J.; McMillan, Donald C.; Maddocks, Matthew

Authors

Marie Fallon

Ross D. Dolan

Louise E. Daly

Claribel P. L. Simmons

Caroline Usborne

Michael I. Bennett

Aoife M. Ryan

Wei M. J. Sim

Derek G. Power

Barry J. Laird

Donald C. McMillan

Matthew Maddocks



Abstract

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Cancer remains one of the leading causes of mortality worldwide and the associated reduction in physical function has a marked impact on both quality of life and survival. The aim of the present study was to examine the relationship between Eastern Cooperative Oncology Group- Performance status (ECOG-PS), modified Glasgow Prognostic Score (mGPS), Body Mass Index/ Weight Loss grade (BMI/WL grade), and Computerised Tomography (CT)-derived body composition measurement and physical function in patients with advanced cancer. Nine sites contributed prospective data on patient demographics, ECOG-PS, mGPS, physical function tests, and CT-derived body composition. Categorical variables were analysed using X2 test for linear-bylinear association, or X2 test for 2-by-2 tables. Associations were analysed using binary logistic regression. A total of 523 cancer patients (266 males, 257 females) were included in the final analysis and most had metastatic disease (83.2%). The median overall survival was 5.6 months. On multivariate binary logistic regression analysis, a high ECOG-PS remained independently associated with a low skeletal muscle index (p < 0.001), low skeletal muscle density (p < 0.05), and timed up and go test failure (p < 0.001). A high mGPS remained independently associated with a low skeletal muscle density (p < 0.05) and hand grip strength test failure (p < 0.01). A high BMI/WL grade remained independently associated with a low subcutaneous fat index (p < 0.05), low visceral obesity (p < 0.01), and low skeletal muscle density (p < 0.05). In conclusion, a high ECOG-PS and a high mGPS as outlined in the ECOG-PS/mGPS framework were consistently associated with poorer body composition and physical function in patients with advanced cancer.

Citation

Fallon, M., Dolan, R. D., Daly, L. E., Simmons, C. P. L., Wilcock, A., Usborne, C., …Maddocks, M. (2020). The relationship between ECOG-PS, mGPS, BMI/WL grade and body composition and physical function in patients with advanced cancer. Cancers, 12(5), https://doi.org/10.3390/cancers12051187

Journal Article Type Article
Acceptance Date May 4, 2020
Online Publication Date May 8, 2020
Publication Date May 1, 2020
Deposit Date Jun 9, 2020
Publicly Available Date Jun 9, 2020
Journal Cancers
Electronic ISSN 2072-6694
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 12
Issue 5
Article Number 1187
DOI https://doi.org/10.3390/cancers12051187
Keywords Cancer Research; Oncology
Public URL https://nottingham-repository.worktribe.com/output/4612346
Publisher URL https://www.mdpi.com/2072-6694/12/5

Files

cancers-12-01187-v2 (1.1 Mb)
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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/





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