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EM-010, Gene expression profiling of pediatric ependymomas from the posterior fossa reveals key differences with adult ependymomas (2014)
Journal Article
Lourdusamy, A., Rogers, H., Rahman, R., Ward, J., & Grundy, R. (2014). EM-010, Gene expression profiling of pediatric ependymomas from the posterior fossa reveals key differences with adult ependymomas. Neuro-Oncology, 16(Suppl_1), i19

BACKGROUND: Ependymoma in children and adults show distinct pathogenesis, biology, and clinical features, it is important to elucidate the transcriptional features that distinguish pediatric ependymomas from adults arising in same anatomical region.... Read More about EM-010, Gene expression profiling of pediatric ependymomas from the posterior fossa reveals key differences with adult ependymomas.

Discrepancies between registration and publication of randomised controlled trials: an observational study (2014)
Journal Article
Walker, K. F., Stevenson, G., & Thornton, J. (2014). Discrepancies between registration and publication of randomised controlled trials: an observational study. Journal of the Royal Society of Medicine, 5(5), https://doi.org/10.1177/2042533313517688

Abstract OBJECTIVES: To determine the consistency between information contained in the registration and publication of randomised controlled trials (RCTs). DESIGN: An observational study of RCTs published between May 2011 and May 2012 in the Brit... Read More about Discrepancies between registration and publication of randomised controlled trials: an observational study.

European Cystic Fibrosis Society standards of care: best practice guidelines (2014)
Journal Article
Smyth, A. R., Bell, S. C., Bojcin, S., Byron, M., Duff, A., Flume, P., …Wolfe, S. (2014). European Cystic Fibrosis Society standards of care: best practice guidelines. Journal of Cystic Fibrosis, 13(Supp 1), Article S23-S42. https://doi.org/10.1016/j.jcf.2014.03.010

Specialised CF care has led to a dramatic improvement in survival in CF: in the last four decades, well above what was seen in the general population over the same period. With the implementation of newborn screening in many European countries, centr... Read More about European Cystic Fibrosis Society standards of care: best practice guidelines.

Risk-proportionate clinical trial monitoring: an example approach from a non-commercial trials unit (2014)
Journal Article
Smith, C. T., Williamson, P., Jones, A., Smyth, A. R., Hewer, S. L., & Gamble, C. (2014). Risk-proportionate clinical trial monitoring: an example approach from a non-commercial trials unit. Trials, 15(127), https://doi.org/10.1186/1745-6215-15-127

Background Some level of monitoring is usually required during a clinical trial to protect the rights and safety of trial participants and to safeguard the quality and reliability of trial results. Although there is increasing support for the use of... Read More about Risk-proportionate clinical trial monitoring: an example approach from a non-commercial trials unit.

Processed pseudogenes acquired somatically during cancer development (2014)
Journal Article
GRUNDY, R., Provenzano, E., Cooke, S. L., van de Vijver, M., Shlien, A., Richardson, A. L., …Hooijer, G. K. (2014). Processed pseudogenes acquired somatically during cancer development. Nature Communications, 5, Article 3644. https://doi.org/10.1038/ncomms4644

Cancer evolves by mutation, with somatic reactivation of retrotransposons being one such mutational process. Germline retrotransposition can cause processed pseudogenes, but whether this occurs somatically has not been evaluated. Here we screen seque... Read More about Processed pseudogenes acquired somatically during cancer development.

Is there any relationship between ABO/Rh blood group and patients with pre-eclampsia? (2014)
Journal Article
Hentchke, M., Caruso, F. B., Paula, L. G., Medeiro, A. K., Gadonski, G., Antonello, I. C., …Pinheiro da Costa, B. (2014). Is there any relationship between ABO/Rh blood group and patients with pre-eclampsia?. Pregnancy Hypertension, 4(2), https://doi.org/10.1016/j.preghy.2014.03.003

Objectives: The purpose of the present study was to evaluate the association between pre-eclampsia and blood groups in a group of pregnant women hospitalized in a University Hospital in Porto Alegre, Brazil -Hospital São Lucas (HSL)/PUCRS. Study de... Read More about Is there any relationship between ABO/Rh blood group and patients with pre-eclampsia?.

Expression of voltage-dependent potassium channels in first trimester human placentae (2014)
Journal Article
Mistry, H. D., Kurlak, L., Whitley, G. S., Cartwright, J. E., Broughton Pipkin, F., & Tribe, R. M. (2014). Expression of voltage-dependent potassium channels in first trimester human placentae. Placenta, 35(5), https://doi.org/10.1016/j.placenta.2014.02.008

Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (Kv7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCN... Read More about Expression of voltage-dependent potassium channels in first trimester human placentae.

Effects of assisted reproductive technologies on human sex ratio at birth (2014)
Journal Article
Maalouf, W. E., Mincheva, M. N., Campbell, B. K., & Hardy, I. C. (2014). Effects of assisted reproductive technologies on human sex ratio at birth. Fertility and Sterility, 101(5), https://doi.org/10.1016/j.fertnstert.2014.01.041

Objective To investigate the effect of assisted reproductive technology (ART) treatments on the sex ratio of babies born. Design Assessment of direct effects of assisted conception through retrospective data analysis on the progeny sex ratio o... Read More about Effects of assisted reproductive technologies on human sex ratio at birth.

Antepartum fetal health (2014)
Journal Article
Tsang, J. C., Tsang, J. C. K., & Jones, N. W. (2014). Antepartum fetal health. Obstetrics, Gynaecology and Reproductive Medicine, 24(3), 80-84. doi:10.1016/j.ogrm.2014.01.002

Delivery of a healthy full term baby following an uneventful antenatal period occurs in the majority of pregnancies. These are classified as a low-risk pregnancy group. There are, however, some pregnancies that are complicated due to maternal or feta... Read More about Antepartum fetal health.

The dangers of the day of birth (2014)
Journal Article
Walker, K., Cohen, A., Walker, S., Allen, K., Baines, D., & Thornton, J. (2014). The dangers of the day of birth. BJOG: An International Journal of Obstetrics and Gynaecology, 121(6), 714-718. doi:10.1111/1471-0528.12544

Once-daily versus multiple-daily dosing with intravenous aminoglycosides for cystic fibrosis (2014)
Journal Article
Smyth, A. R., & Bhatt, J. (2014). Once-daily versus multiple-daily dosing with intravenous aminoglycosides for cystic fibrosis. Cochrane Library, https://doi.org/10.1002/14651858.CD002009.pub5

Background: People with cystic fibrosis, who are chronically colonised with the organism Pseudomonas aeruginosa, often require multiple courses of intravenous aminoglycoside antibiotics for the management of pulmonary exacerbations. The properties of... Read More about Once-daily versus multiple-daily dosing with intravenous aminoglycosides for cystic fibrosis.

Effect of ethnicity on live birth rates after in vitro fertilisation or intracytoplasmic sperm injection treatment (2014)
Journal Article
Jayaprakasan, K., Pandian, D., Hopkisson, J., Campbell, B., & Maalouf, W. (2014). Effect of ethnicity on live birth rates after in vitro fertilisation or intracytoplasmic sperm injection treatment. BJOG: An International Journal of Obstetrics and Gynaecology, 121(3), https://doi.org/10.1111/1471-0528.12504

Objective To assess the relationship between the ethnicity of women and the clinical success of in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) treatment. Design Observational cohort study. Setting Nottingham University R... Read More about Effect of ethnicity on live birth rates after in vitro fertilisation or intracytoplasmic sperm injection treatment.

Effect of maternal protein restriction during pregnancy and postweaning high-fat feeding on diet-induced thermogenesis in adult mouse offspring (2014)
Journal Article
Sellayah, D., Dib, L., Anthony, F., Watkins, A., Fleming, T., Hanson, M., & Cagampang, F. (2014). Effect of maternal protein restriction during pregnancy and postweaning high-fat feeding on diet-induced thermogenesis in adult mouse offspring. European Journal of Nutrition, 53(7), 1523-1531. https://doi.org/10.1007/s00394-014-0657-4

Overcoming multiple drug resistance mechanisms in medulloblastoma (2014)
Journal Article
Othman, R., Coyle, B., Kimishi, I., Bradshaw, T. D., Storer, L., Korshunov, A., …Kerr, I. D. (2014). Overcoming multiple drug resistance mechanisms in medulloblastoma. Acta Neuropathologica Communications, 2(1), Article 57. https://doi.org/10.1186/2051-5960-2-57

© 2014 Othman et al.; licensee BioMed Central Ltd. Introduction: Medulloblastoma (MB) is the most common malignant paediatric brain tumour. Recurrence and progression of disease occurs in 15-20% of standard risk and 30-40% of high risk patients. We a... Read More about Overcoming multiple drug resistance mechanisms in medulloblastoma.

RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells (2014)
Journal Article
Lagah, S., Tan, I., Radhakrishnan, P., Hirst, R. A., Ward, J. H., O'Callaghan, C., …Rahman, R. (2014). RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells. PLoS ONE, 9(1), Article e86187. https://doi.org/10.1371/journal.pone.0086187

Background Telomeric 3’ overhangs can fold into a four-stranded DNA structure termed G-quadruplex (G4), a formation which inhibits telomerase. As telomerase activation is crucial for telomere maintenance in most cancer cells, several classes of G4... Read More about RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.

Rate of improvement of CF life expectancy exceeds that of general population: observational death registration study (2014)
Journal Article
Hurley, M., McKeever, T. M., Prayle, A. P., Smyth, A. R., & Fogarty, A. W. (2014). Rate of improvement of CF life expectancy exceeds that of general population: observational death registration study. Journal of Cystic Fibrosis, 13(4), https://doi.org/10.1016/j.jcf.2013.12.002

Background: It is unclear why cystic fibrosis (CF) survival has improved. We wished to quantify increases in CF median age of death in the context of general population survival improvement. Method: Death registration data analysis (US, England & Wa... Read More about Rate of improvement of CF life expectancy exceeds that of general population: observational death registration study.

Multiplexing Spheroid Volume, Resazurin and Acid Phosphatase Viability Assays for High-Throughput Screening of Tumour Spheroids and Stem Cell Neurospheres (2014)
Journal Article
Alexander, C., Ivanov, D. P., WALKER, D., Parker, T. L., GARNETT, M., Ashford, M. B., & Gellert, P. R. (2014). Multiplexing Spheroid Volume, Resazurin and Acid Phosphatase Viability Assays for High-Throughput Screening of Tumour Spheroids and Stem Cell Neurospheres. PLoS ONE, 9(8), https://doi.org/10.1371/journal.pone.0103817

Three-dimensional cell culture has many advantages over monolayer cultures, and spheroids have been hailed as the best current representation of small avascular tumours in vitro. However their adoption in regular screening programs has been hindered... Read More about Multiplexing Spheroid Volume, Resazurin and Acid Phosphatase Viability Assays for High-Throughput Screening of Tumour Spheroids and Stem Cell Neurospheres.

The influence of circulating anti-Müllerian hormone on ovarian responsiveness to ovulation induction with gonadotrophins in women with polycystic ovarian syndrome: a pilot study (2013)
Journal Article
Amer, S. A., Mahran, A., Abdelmaged, A., El-Adawy, A. R., Eissa, M. K., & Shaw, R. W. (2013). The influence of circulating anti-Müllerian hormone on ovarian responsiveness to ovulation induction with gonadotrophins in women with polycystic ovarian syndrome: a pilot study. Reproductive Biology and Endocrinology, 11(115), Article 115. https://doi.org/10.1186/1477-7827-11-115

Background Women with polycystic ovarian syndrome (PCOS) are known to have elevated circulating Anti-Müllerian hormone (AMH), which has been found to desensitize ovarian follicles to follicle stimulating hormone (FSH). The purpose of this study was... Read More about The influence of circulating anti-Müllerian hormone on ovarian responsiveness to ovulation induction with gonadotrophins in women with polycystic ovarian syndrome: a pilot study.