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Effects of assisted reproductive technologies on human sex ratio at birth

Maalouf, Walid E.; Mincheva, Mina N.; Campbell, Bruce K.; Hardy, Ian C.W.

Authors

Walid E. Maalouf

Mina N. Mincheva

Bruce K. Campbell

Ian C.W. Hardy



Abstract

Objective

To investigate the effect of assisted reproductive technology (ART) treatments on the sex ratio of babies born.
Design

Assessment of direct effects of assisted conception through retrospective data analysis on the progeny sex ratio of treated women in the United Kingdom.
Setting

The study uses the anonymized register of the Human Fertilisation and Embryology Authority.
Patient(s)

A total of 106,066 babies of known gender born to 76,994 treated mothers and 85,511 treatment cycles between 2000 and 2010 in the United Kingdom.
Intervention(s)

Intrauterine insemination, IVF, or intracytoplasmic sperm injection (ICSI).
Main Outcome Measure(s)

Sex ratio of babies born.
Result(s)

Intrauterine insemination, IVF, and ICSI lead to different sex ratios, highest after IVF (proportion male = mean 0.521 ± confidence interval 0.0056) and lowest under ICSI embryo transfer (0.493 ± 0.0031). In addition, for both ICSI and IVF, transferring embryos at a later stage (blastocyst) results in approximately 6% more males than after early cleavage-stage ET.
Conclusion(s)

Because the cumulative number of IVF babies born is increasing significantly in Britain and elsewhere, more research is needed into the causes of gender bias after ART and into the public health impact of such gender bias of offspring born observed on the rest of the population.

Journal Article Type Article
Publication Date May 1, 2014
Journal Fertility and Sterility
Print ISSN 0015-0282
Electronic ISSN 1556-5653
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 101
Issue 5
APA6 Citation Maalouf, W. E., Mincheva, M. N., Campbell, B. K., & Hardy, I. C. (2014). Effects of assisted reproductive technologies on human sex ratio at birth. Fertility and Sterility, 101(5), doi:10.1016/j.fertnstert.2014.01.041
DOI https://doi.org/10.1016/j.fertnstert.2014.01.041
Keywords Sex ratio; gender bias; embryo; ART births; IUI; IVF; ICSI
Publisher URL http://www.sciencedirect.com/science/article/pii/S0015028214000892
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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