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All Outputs (817)

Building toolkits for COPD exacerbations: lessons from the past and present (2019)
Journal Article
Sapey, E., Bafadhel, M., Bolton, C. E., Wilkinson, T., Hurst, J. R., & Quint, J. K. (2019). Building toolkits for COPD exacerbations: lessons from the past and present. Thorax, 74(9), 898-905. https://doi.org/10.1136/thoraxjnl-2018-213035

In the nineteenth century, it was recognised that acute attacks of chronic bronchitis were harmful. 140 years later, it is clearer than ever that exacerbations of chronic obstructive pulmonary disease (ECOPD) are important events. They are associated... Read More about Building toolkits for COPD exacerbations: lessons from the past and present.

Allogeneic Stem Cell Transplantation for Blast Crisis Chronic Myeloid Leukemia in the Era of Tyrosine Kinase Inhibitors: A Retrospective Study by the EBMT Chronic Malignancies Working Party (2019)
Journal Article
Radujkovic, A., Dietrich, S., Blok, H., Nagler, A., Ayuk, F., Finke, J., …EBMT Chronic Malignancies Working Party. (2019). Allogeneic Stem Cell Transplantation for Blast Crisis Chronic Myeloid Leukemia in the Era of Tyrosine Kinase Inhibitors: A Retrospective Study by the EBMT Chronic Malignancies Working Party. Biology of Blood and Marrow Transplantation, 25(10), 2008-2016. https://doi.org/10.1016/j.bbmt.2019.06.028

The prognosis of patients with blast crisis (BC) chronic myeloid leukemia (CML) is still dismal. Allogeneic stem cell transplantation (alloSCT) represents the only curative treatment option, but data on transplant outcomes are scarce. We therefore co... Read More about Allogeneic Stem Cell Transplantation for Blast Crisis Chronic Myeloid Leukemia in the Era of Tyrosine Kinase Inhibitors: A Retrospective Study by the EBMT Chronic Malignancies Working Party.

A Hybrid Evolutionary Strategy to Optimise Early-Stage Cancer Screening (2019)
Conference Proceeding
Figueredo, G. P., Shi, P., Parkes, A. J., Evans, K., Garibaldi, J. M., Negm, O., …Robertson, J. (2019). A Hybrid Evolutionary Strategy to Optimise Early-Stage Cancer Screening. In 2019 IEEE Congress on Evolutionary Computation (CEC) (95-102). https://doi.org/10.1109/CEC.2019.8790316

Current methods to identify cutoff values for tumour-associated molecules (antigens) discrimination are based on statistics and brute force. These methods applied to cancer screening problems are very inefficient, especially with large data sets with... Read More about A Hybrid Evolutionary Strategy to Optimise Early-Stage Cancer Screening.

Clinical onset of atopic eczema: results from two nationally representative British birth cohorts followed through mid-life (2019)
Journal Article
Abubara, K., Ye, M., McCulloch, C. E., Sullivan, A., Margolis, D. J., Strachan, D. P., …Langan, S. M. (2019). Clinical onset of atopic eczema: results from two nationally representative British birth cohorts followed through mid-life. Journal of Allergy and Clinical Immunology, 144(3), 710–719. https://doi.org/10.1016/j.jaci.2019.05.040

Background Atopic eczema onset is described primarily in early childhood; the frequency and characteristics of adult-onset disease remain controversial. Objective To determine the proportion of individuals who report atopic eczema symptoms between... Read More about Clinical onset of atopic eczema: results from two nationally representative British birth cohorts followed through mid-life.

Development and implementation of a commissioned pathway for the identification and stratification of liver disease in the community (2019)
Journal Article
Chalmers, J., Wilkes, E., Harris, R., Kent, L., Kinra, S., Aithal, G., …Guha, I. N. (2020). Development and implementation of a commissioned pathway for the identification and stratification of liver disease in the community. Frontline Gastroenterology, 11(2), 86-92. https://doi.org/10.1136/flgastro-2019-101177

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. Objective: To describe the development of the Nottingham liver disease stratification pathway, present a 12-month evaluation of uptake and stratification results... Read More about Development and implementation of a commissioned pathway for the identification and stratification of liver disease in the community.

Motivation as a mechanism underpinning exercise-based falls prevention programmes for older adults with cognitive impairment: a realist review (2019)
Journal Article
Booth, V., Harwood, R. H., Hancox, J. E., Hood-Moore, V., Masud, T., & Logan, P. (2019). Motivation as a mechanism underpinning exercise-based falls prevention programmes for older adults with cognitive impairment: a realist review. BMJ Open, 9(6), https://doi.org/10.1136/bmjopen-2018-024982

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. Objectives This review aimed to identify mechanisms underlying participation in falls prevention interventions, in older adults with cognitive impairment. In par... Read More about Motivation as a mechanism underpinning exercise-based falls prevention programmes for older adults with cognitive impairment: a realist review.

Aural fullness and transtympanic ventilation tubes in Ménière's disease: a scoping review (2019)
Journal Article
Sevilla, C., Goody, J., Baguley, D. M., & Kasbekar, A. V. (2019). Aural fullness and transtympanic ventilation tubes in Ménière's disease: a scoping review. Journal of Laryngology and Otology, 133(6), 450-456. https://doi.org/10.1017/S002221511900094X

Background: Ménière’s Disease (MD) often presents with aural fullness, for reasons that are currently not well understood. Insertion of transtympanic ventilation tubes (VTs) has been historically used for the management of this symptom, though the na... Read More about Aural fullness and transtympanic ventilation tubes in Ménière's disease: a scoping review.

A prospective study examining cachexia predictors in patients with incurable cancer (2019)
Journal Article
Vagnildhaug, O. M., Brunelli, C., Hjermstad, M. J., Strasser, F., Baracos, V., Wilcock, A., …Solheim, T. S. (2019). A prospective study examining cachexia predictors in patients with incurable cancer. BMC Palliative Care, 18, Article 46. https://doi.org/10.1186/s12904-019-0429-2

© 2019 The Author(s). Background: Early intervention against cachexia necessitates a predictive model. The aims of this study were to identify predictors of cachexia development and to create and evaluate accuracy of a predictive model based on these... Read More about A prospective study examining cachexia predictors in patients with incurable cancer.

Autologous stem cell transplantation in refractory Crohn’s disease – low intensity therapy evaluation (ASTIClite): study protocols for a multicentre, randomised controlled trial and observational follow up study (2019)
Journal Article
Snowden, J. A., Hawkey, C., Hind, D., Swaby, L., Mellor, K., Emsley, R., …European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP). (2019). Autologous stem cell transplantation in refractory Crohn’s disease – low intensity therapy evaluation (ASTIClite): study protocols for a multicentre, randomised controlled trial and observational follow up study. BMC Gastroenterology, 19, Article 82. https://doi.org/10.1186/s12876-019-0992-2

Background Intestinal inflammation in Crohn’s disease (CD) is caused by mucosal immune system reactivity to luminal antigen and results in debilitating symptoms, reduced quality of life, impaired work productivity and significant health care costs.... Read More about Autologous stem cell transplantation in refractory Crohn’s disease – low intensity therapy evaluation (ASTIClite): study protocols for a multicentre, randomised controlled trial and observational follow up study.

Interferon gamma release assays for Diagnostic Evaluation of Active tuberculosis (IDEA): test accuracy study and economic evaluation (2019)
Journal Article
Takwoingi, Y., Whitworth, H., Rees-Roberts, M., Badhan, A., Partlett, C., Green, N., …Interferon Gamma Release Assays for Diagnostic Evaluation of Active Tuberculosis (IDEA) study group. (2019). Interferon gamma release assays for Diagnostic Evaluation of Active tuberculosis (IDEA): test accuracy study and economic evaluation. Health Technology Assessment, 23(23), 1-184. https://doi.org/10.3310/hta23230

© Queen’s Printer and Controller of HMSO 2019. Background: Interferon gamma release assays (IGRAs) are blood tests recommended for the diagnosis of tuberculosis (TB) infection. There is currently uncertainty about the role and clinical utility of IGR... Read More about Interferon gamma release assays for Diagnostic Evaluation of Active tuberculosis (IDEA): test accuracy study and economic evaluation.

Short-term pre-operative high-intensity interval training does not improve fitness of colorectal cancer patients (2019)
Journal Article
Boereboom, C. L., Blackwell, J. E., Williams, J. P., Phillips, B. E., & Lund, J. N. (2019). Short-term pre-operative high-intensity interval training does not improve fitness of colorectal cancer patients. Scandinavian Journal of Medicine and Science in Sports, 29(9), 1383-1391. https://doi.org/10.1111/sms.13460

Background: Preoperative cardiorespiratory fitness (CRF) in colorectal cancer patients has been shown to affect postoperative outcomes. The aim of this study was to test the feasibility of high-intensity interval training (HIT) for improving fitness... Read More about Short-term pre-operative high-intensity interval training does not improve fitness of colorectal cancer patients.

Overall survival in malignant glioma is significantly prolonged by neurosurgical delivery of etoposide and temozolomide from a thermo-responsive biodegradable paste (2019)
Journal Article
Smith, S. J., Tyler, B., Gould, T. W., Veal, G. J., Gorelick, N. L., Rowlinson, J., …Rahman, R. (2019). Overall survival in malignant glioma is significantly prolonged by neurosurgical delivery of etoposide and temozolomide from a thermo-responsive biodegradable paste. Clinical Cancer Research, 25(16), 5094-5106. https://doi.org/10.1158/1078-0432.ccr-18-3850

Purpose: High-grade glioma (HGG) treatment is limited by the inability of otherwise potentially efficacious drugs to penetrate the blood brain barrier. We evaluate the unique intra-cavity delivery mode and translational potential of a blend of poly(D... Read More about Overall survival in malignant glioma is significantly prolonged by neurosurgical delivery of etoposide and temozolomide from a thermo-responsive biodegradable paste.

Encouraging performance monitoring promotes proactive control in children (2019)
Journal Article
Hadley, L. V., Acluche, F., & Chevalier, N. (2020). Encouraging performance monitoring promotes proactive control in children. Developmental Science, 23(1), https://doi.org/10.1111/desc.12861

Monitoring progression towards one’s goals is essential for efficient cognitive control. Immature performance monitoring may contribute to suboptimal cognitive control engagement in childhood, potentially explaining why children engage control reacti... Read More about Encouraging performance monitoring promotes proactive control in children.

A meta-analysis of clinical benefit rates for fulvestrant 500 mg vs. alternative endocrine therapies for hormone receptor-positive advanced breast cancer (2019)
Journal Article
Robertson, J. F. R., Jiang, Z., Di Leo, A., Ohno, S., Pritchard, K. I., Ellis, M., …Campbell, C. (2019). A meta-analysis of clinical benefit rates for fulvestrant 500 mg vs. alternative endocrine therapies for hormone receptor-positive advanced breast cancer. Breast Cancer, 26(6), 703-711. https://doi.org/10.1007/s12282-019-00973-4

Background Fulvestrant, a selective estrogen receptor degrader, is approved for first- and second-line treatment of postmenopausal women with hormone receptor-positive advanced breast cancer (ABC). Methods Meta-analysis of randomized controlled... Read More about A meta-analysis of clinical benefit rates for fulvestrant 500 mg vs. alternative endocrine therapies for hormone receptor-positive advanced breast cancer.

A pilot study of visceral fat and its association with adipokines, stool calprotectin and symptoms in patients with diverticulosis (2019)
Journal Article
Murray, K., Hoad, C., Garratt, J., Kaviani, M., Marciani, L., Smith, J., …Spiller, R. (2019). A pilot study of visceral fat and its association with adipokines, stool calprotectin and symptoms in patients with diverticulosis. PLoS ONE, 14(5), Article e0216528. https://doi.org/10.1371/journal.pone.0216528

Background Complications of diverticular disease are increasingly common, possibly linked to increasing obesity. Visceral fat could contribute to the development of symptomatic diverticular disease through its pro-inflammatory effects. Objective... Read More about A pilot study of visceral fat and its association with adipokines, stool calprotectin and symptoms in patients with diverticulosis.

Metadherin: A Therapeutic Target in Multiple Cancers (2019)
Journal Article
Dhiman, G., Srivastava, N., Goyal, M., Rakha, E., Lothion-Roy, J., Mongan, N. P., …Baranwal, M. (2019). Metadherin: A Therapeutic Target in Multiple Cancers. Frontiers in Oncology, 9, Article 349. https://doi.org/10.3389/fonc.2019.00349

Altered expression of many genes and proteins is essential for cancer development and progression. Recently, the affected expression of metadherin (MTDH), also known as AEG-1 (Astrocyte Elevated Gene 1) and Lyric, has been implicated in various aspec... Read More about Metadherin: A Therapeutic Target in Multiple Cancers.

Slow cycling intestinal stem cell and Paneth cell responses to Trichinella spiralis infection (2019)
Journal Article
Javkar, T., Hughes, K. R., Sablitzky, F., Behnke, J. M., & Mahida, Y. R. (2020). Slow cycling intestinal stem cell and Paneth cell responses to Trichinella spiralis infection. Parasitology International, 74, Article 101923. https://doi.org/10.1016/j.parint.2019.05.001

There is limited information regarding responses by slow cycling stem cells during T. spiralis-induced T-cell mediated intestinal inflammation and how such responses may relate to those of Paneth cells. Transgenic mice, in which doxycycline induces e... Read More about Slow cycling intestinal stem cell and Paneth cell responses to Trichinella spiralis infection.

How do we know that our patients have benefitted from our ENT/Audiological interventions?: presented at the Annual Meeting of ADANO 2016 in Berlin (2019)
Journal Article
Hall, D. A., Kitterick, P. T., Heffernan, E., Fackrell, K., Lucas, L., & Ferguson, M. (2019). How do we know that our patients have benefitted from our ENT/Audiological interventions?: presented at the Annual Meeting of ADANO 2016 in Berlin. Otology and Neurotology, 40(4), e474-e481. https://doi.org/10.1097/MAO.0000000000001937

This short review article gives an introduction to some of the fundamental concepts and challenges facing measurement in hearing healthcare practice and research. The impact of hearing loss almost always extends beyond the sensory impairment itself,... Read More about How do we know that our patients have benefitted from our ENT/Audiological interventions?: presented at the Annual Meeting of ADANO 2016 in Berlin.

Circulating levels of the anti-oxidant indoleproprionic acid are associated with higher gut microbiome diversity (2019)
Journal Article
Menni, C., Hernandez, M. M., Vital, M., Mohney, R. P., Spector, T. D., & Valdes, A. M. (2019). Circulating levels of the anti-oxidant indoleproprionic acid are associated with higher gut microbiome diversity. Gut Microbes, 10(6), 688-695. https://doi.org/10.1080/19490976.2019.1586038

The gut microbiome has recently emerged as an important regulator of insulin resistance and abdominal obesity. The tryptophan metabolite generated by the gut microbiome, indoleproprionic acid (IPA) has been shown to predict the onset of type 2 diabet... Read More about Circulating levels of the anti-oxidant indoleproprionic acid are associated with higher gut microbiome diversity.