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Circulating levels of the anti-oxidant indoleproprionic acid are associated with higher gut microbiome diversity

Abstract

The gut microbiome has recently emerged as an important regulator of insulin resistance and abdominal obesity. The tryptophan metabolite generated by the gut microbiome, indoleproprionic acid (IPA) has been shown to predict the onset of type 2 diabetes. IPA is a metabolite produced by gut microbes from dietary tryptophan that exhibits a high degree of inter-individual variation. The microbiome composition parameters that are associated with circulating levels of this potent anti-oxidant have however not been investigated to date in human populations. In 1018 middle-aged women from the TwinsUK cohort, we assessed the relationship between serum IPA levels and gut microbiome composition targeting the 16S rRNA gene. Microbiome alpha-diversity was positively correlated with serum indoleproprionic acid levels (Shannon Diversity: Beta[95%CI] = 0.19[0.13;0.25], P = 6.41 × 10−10) after adjustment for covariates. Sixteen taxa and 12 operational taxonomic units (OTUs) associated with IPA serum levels. Among these are positive correlations with the butyrate-producing Faecalibacterium prausnitzii, the class Mollicutes and the order RF39 of the Tenericutes, and Coprococcus Negative correlations instead were observed with Eubacterium dolichum previously shown to correlate with visceral fat mass and several genera in the Lachnospiraceae family such as Blautia and Ruminococcus previously shown to correlate with obesity. Microbiome composition parameters explained ~20% of the variation in circulating levels of IPA, whereas nutritional and host genetic parameters explained only ~4%. Our data confirm an association between IPA circulating levels and metabolic syndrome parameters and indicate that gut microbiome composition influences IPA levels.

Journal Article Type Article
Publication Date Nov 2, 2019
Journal Gut Microbes
Print ISSN 1949-0976
Electronic ISSN 1949-0984
Publisher Taylor & Francis Open
Peer Reviewed Peer Reviewed
Volume 10
Issue 6
Pages 688-695
APA6 Citation Menni, C., Hernandez, M. M., Vital, M., Mohney, R. P., Spector, T. D., & Valdes, A. M. (2019). Circulating levels of the anti-oxidant indoleproprionic acid are associated with higher gut microbiome diversity. Gut Microbes, 10(6), 688-695. https://doi.org/10.1080/19490976.2019.1586038
DOI https://doi.org/10.1080/19490976.2019.1586038
Publisher URL https://www.tandfonline.com/doi/full/10.1080/19490976.2019.1586038
Additional Information Peer Review Statement: The publishing and review policy for this title is described in its Aims & Scope.; Aim & Scope: http://www.tandfonline....ope&journalCode=kgmi20; Received: 2018-10-17; Revised: 2019-01-25; Accepted: 2019-02-17; Published: 2019-04-29

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