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Evaluating the role of a humanoid robot to support learning in children with profound and multiple disabilities (2014)
Journal Article
Hedgecock, J., Standen, P. J., Beer, C., & Brown, D. (2014). Evaluating the role of a humanoid robot to support learning in children with profound and multiple disabilities. Journal of Assistive Technologies, 8(3), 111-123. https://doi.org/10.1108/JAT-02-2014-0006

Purpose The purpose of this paper is to identify ways teachers might employ a robot to achieve learning objectives with pupils with intellectual disabilities and potential outcome measures. Design/methodology/approach A series of five case studi... Read More about Evaluating the role of a humanoid robot to support learning in children with profound and multiple disabilities.

Engaging students with profound and multiple disabilities using humanoid robots (2014)
Journal Article
Standen, P., Brown, D., Roscoe, J., Hedgecock, J., Stewart, D., Galvez Trigo, M. J., & Elgajiji, E. (2014). Engaging students with profound and multiple disabilities using humanoid robots. 00 Journal not listed, 8514, 419-430. https://doi.org/10.1007/978-3-319-07440-5_39

Engagement is the single best predictor of successful learning for children with intellectual disabilities yet achieving engagement with pupils who have profound or multiple disabilities (PMD) presents a challenge to educators. Robots have been used... Read More about Engaging students with profound and multiple disabilities using humanoid robots.

Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation (2014)
Journal Article
Dixon, J. E., Shah, D. A., Rogers, C., Hall, S., Weston, N., Parmenter, C. D., …Shakesheff, K. M. (2014). Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation. Proceedings of the National Academy of Sciences, 111(15), 5580-5585. https://doi.org/10.1073/pnas.1319685111

The ability of materials to define the architecture and microenvironment experienced by cells provides new opportunities to direct the fate of human pluripotent stem cells (HPSCs) [Robinton DA, Daley GQ (2012) Nature 481(7381):295-305]. However, the... Read More about Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation.

Spaceflight and ageing: reflecting on Caenorhabditis elegans in space (2014)
Journal Article
Honda, Y., Honda, S., Narici, M., & Szewczyk, N. (2014). Spaceflight and ageing: reflecting on Caenorhabditis elegans in space. Gerontology, 60(2), https://doi.org/10.1159/000354772

The prospect of space travel continues to capture the imagination. Several competing companies are now promising flights for the general population. Previously, it was recognized that many of the physiological changes that occur with spaceflight are... Read More about Spaceflight and ageing: reflecting on Caenorhabditis elegans in space.

Differential Effects of FODMAPs (Fermentable Oligo-, Di-, Mono-Saccharides and Polyols) on Small and Large Intestinal Contents in Healthy Subjects Shown by MRI (2014)
Journal Article
Murray, K., Wilkinson-Smith, V., Hoad, C., Costigan, C., Cox, E., Lam, C., …Spiller, R. C. (2014). Differential Effects of FODMAPs (Fermentable Oligo-, Di-, Mono-Saccharides and Polyols) on Small and Large Intestinal Contents in Healthy Subjects Shown by MRI. American Journal of Gastroenterology, 109(1), 110-119. https://doi.org/10.1038/ajg.2013.386

OBJECTIVES:The objective of this study was to investigate whether ingestion of fructose and fructans (such as inulin) can exacerbate irritable bowel syndrome (IBS) symptoms. The aim was to better understand the origin of these symptoms by magnetic re... Read More about Differential Effects of FODMAPs (Fermentable Oligo-, Di-, Mono-Saccharides and Polyols) on Small and Large Intestinal Contents in Healthy Subjects Shown by MRI.

DNA content analysis of colorectal cancer defines a distinct ‘microsatellite and chromosome stable’ group but does not predict response to radiotherapy (2014)
Journal Article
Fadhil, W., Kindle, K., Jackson, D., Zaitoun, A. M., Lane, N., Robins, A., & Ilyas, M. (2014). DNA content analysis of colorectal cancer defines a distinct ‘microsatellite and chromosome stable’ group but does not predict response to radiotherapy. International Journal of Experimental Pathology, 95(1), https://doi.org/10.1111/iep.12070

Colorectal cancers (CRC) are thought to have genetic instability in the form of either microsatellite instability (MSI) or chromosomal instability (CIN). Recently, tumours have been described without either MSI or CIN, that is, microsatellite and chr... Read More about DNA content analysis of colorectal cancer defines a distinct ‘microsatellite and chromosome stable’ group but does not predict response to radiotherapy.

Antibiotic prescribing in primary care and antimicrobial resistance in patients admitted to hospital with urinary tract infection: a controlled observational pilot study (2014)
Journal Article
Costelloe, C., Williams, O. M., Montgomery, A. A., Dayan, C., & Hay, A. D. (2014). Antibiotic prescribing in primary care and antimicrobial resistance in patients admitted to hospital with urinary tract infection: a controlled observational pilot study. Antibiotics, 3(1), https://doi.org/10.3390/antibiotics3010029

There is growing evidence that primary care prescribed antibiotics lead to antibiotic resistance in bacteria causing minor infections or being carried by asymptomatic adults, but little research to date has investigated links between primary care pre... Read More about Antibiotic prescribing in primary care and antimicrobial resistance in patients admitted to hospital with urinary tract infection: a controlled observational pilot study.

The impact of amelogenesis imperfecta and support needs of adolescents with AI and their parents: an exploratory study (2014)
Journal Article
Sneller, J., Buchanan, H., & Parekh, S. (2014). The impact of amelogenesis imperfecta and support needs of adolescents with AI and their parents: an exploratory study. International Journal of Paediatric Dentistry, 24(6), https://doi.org/10.1111/ipd.12086

BACKGROUND: Amelogenesis imperfecta (AI) is a rare inherited dental defect where enamel does not form properly on the teeth. Research has shown that adolescents with AI may experience adverse psychosocial effects; however the impact on parents has n... Read More about The impact of amelogenesis imperfecta and support needs of adolescents with AI and their parents: an exploratory study.

Effect of 3 to 5 years of scheduled CEA and CT follow-upto detect recurrence of colorectal cancer The FACS Randomized Clinical Trial (2014)
Journal Article
Primrose, J. N., Perera, R., Gray, A., Rose, P., Fuller, A., Corkhill, A., …FACS Trial Investigators. (2014). Effect of 3 to 5 years of scheduled CEA and CT follow-upto detect recurrence of colorectal cancer The FACS Randomized Clinical Trial. Journal of the American Medical Association, 311(3), https://doi.org/10.1001/jama.2013.285718

IMPORTANCE Intensive follow-up after surgery for colorectal cancer is common practice but is based on limited evidence. OBJECTIVE To assess the effect of scheduled blood measurement of carcinoembryonic antigen (CEA) and computed tomography (CT) as f... Read More about Effect of 3 to 5 years of scheduled CEA and CT follow-upto detect recurrence of colorectal cancer The FACS Randomized Clinical Trial.

The ‘Swallow Tail’ Appearance of the Healthy Nigrosome – A New Accurate Test of Parkinson's Disease: A Case-Control and Retrospective Cross-Sectional MRI Study at 3T (2014)
Journal Article
Schwarz, S., Afzal, M., Morgan, P., Auer, D., Bajaj, N., & Gowland, P. A. (2014). The ‘Swallow Tail’ Appearance of the Healthy Nigrosome – A New Accurate Test of Parkinson's Disease: A Case-Control and Retrospective Cross-Sectional MRI Study at 3T. PLoS ONE, 9(4), Article e93814. https://doi.org/10.1371/journal.pone.0093814

There is no well-established in vivo marker of nigral degeneration in Parkinson's disease (PD). An ideal imaging marker would directly mirror the loss of substantia nigra dopaminergic neurones, which is most prominent in sub-regions called nigrosomes... Read More about The ‘Swallow Tail’ Appearance of the Healthy Nigrosome – A New Accurate Test of Parkinson's Disease: A Case-Control and Retrospective Cross-Sectional MRI Study at 3T.

Optimal short-time acquisition schemes in high angular resolution diffusion-weighted imaging (2013)
Journal Article
Prčkovska, V., Achterberg, H. C., Bastiani, M., Pullens, P., Balmashnova, E., ter Haar Romeny, B. M., …Roebroeck, A. (2013). Optimal short-time acquisition schemes in high angular resolution diffusion-weighted imaging. International Journal of Biomedical Imaging, 2013, Article 658583. https://doi.org/10.1155/2013/658583

This work investigates the possibilities of applying high-angular-resolution-diffusion-imaging- (HARDI-) based methods in a clinical setting by investigating the performance of non-Gaussian diffusion probability density function (PDF) estimation for... Read More about Optimal short-time acquisition schemes in high angular resolution diffusion-weighted imaging.

Off-line breath acetone analysis in critical illness (2013)
Journal Article
Sturney, S. C., Storer, M., Shaw, D. E., & Epton, M. (2013). Off-line breath acetone analysis in critical illness. Journal of Breath Research, 7(3), https://doi.org/10.1088/1752-7155/7/3/037102

Analysis of breath acetone could be useful in the Intensive Care Unit (ICU) setting to monitor evidence of starvation and metabolic stress. The aims of this study were to examine the relationship between acetone concentrations in breath and blood in... Read More about Off-line breath acetone analysis in critical illness.

Neuromuscular electrical stimulation of the quadriceps in patients with non-small cell lung cancer receiving palliative chemotherapy: a randomized Phase II study (2013)
Journal Article
Lucia, A., Maddocks, M., Halliday, V., Chauhan, A., Taylor, V., Nelson, A., …Wilcock, A. (2013). Neuromuscular electrical stimulation of the quadriceps in patients with non-small cell lung cancer receiving palliative chemotherapy: a randomized Phase II study. PLoS ONE, 8(12), Article e86059. https://doi.org/10.1371/journal.pone.0086059

Background A reduced exercise capacity is associated with increased morbidity and mortality in patients with advanced non-small cell lung cancer (NSCLC). Therapeutic exercise can be beneficial and neuromuscular electrical stimulation (NMES) of the... Read More about Neuromuscular electrical stimulation of the quadriceps in patients with non-small cell lung cancer receiving palliative chemotherapy: a randomized Phase II study.

Surgical excision versus imiquimod 5% cream for nodular and superficial basal-cell carcinoma (SINS): a multicentre, non-inferiority, randomised controlled trial (2013)
Journal Article
Bath-Hextall, F., Ozolins, M., Armstrong, S. J., Colver, G. B., Perkins, W., Miller, P. S., & Williams, H. C. (2014). Surgical excision versus imiquimod 5% cream for nodular and superficial basal-cell carcinoma (SINS): a multicentre, non-inferiority, randomised controlled trial. Lancet Oncology, 15(1), 96-105. https://doi.org/10.1016/S1470-2045%2813%2970530-8

Background: Basal-cell carcinoma is the most common form of skin cancer and its incidence is increasing worldwide. We aimed to assess the effectiveness of imiquimod cream versus surgical excision in patients with low-risk basal-cell carcinoma. Method... Read More about Surgical excision versus imiquimod 5% cream for nodular and superficial basal-cell carcinoma (SINS): a multicentre, non-inferiority, randomised controlled trial.

Can theory of mind deficits be measured reliably in people with mild and moderate Alzheimer’s dementia? (2013)
Journal Article
Choong, C. S., & Doody, G. A. (2013). Can theory of mind deficits be measured reliably in people with mild and moderate Alzheimer’s dementia?. BMC Psychology, 1(Decemb), Article 9. https://doi.org/10.1186/2050-7283-1-28

Background Patients suffering from Alzheimer’s dementia develop difficulties in social functioning. This has led to an interest in the study of “theory of mind” in this population. However, difficulty has arisen because the associated cognitive dema... Read More about Can theory of mind deficits be measured reliably in people with mild and moderate Alzheimer’s dementia?.

Metrics and textural features of MRI diffusion to improve classification of pediatric posterior fossa tumors (2013)
Journal Article
Rodriguez Gutierrez, D., Awwad, A., Meijer, L., Manita, M., Jaspan, T., Dineen, R. A., …Auer, D. P. (in press). Metrics and textural features of MRI diffusion to improve classification of pediatric posterior fossa tumors. American Journal of Neuroradiology, 35(5), https://doi.org/10.3174/ajnr.A3784

BACKGROUND AND PURPOSE: Qualitative radiologic MR imaging review affords limited differentiation among types of pediatric posterior fossa brain tumors and cannot detect histologic or molecular subtypes, which could help to stratify treatment. This st... Read More about Metrics and textural features of MRI diffusion to improve classification of pediatric posterior fossa tumors.

Spending by primary care practices-does it show what we expect? (2013)
Journal Article
James, M., & Stokes, E. (2014). Spending by primary care practices-does it show what we expect?. International Journal of Health Planning and Management, 29(3), 244-259. https://doi.org/10.1002/hpm.2224

Background Over recent years, a number of policies and financial incentives in primary care have been proposed to tackle issues such as deprivation and health outcomes. This article investigates the association between healthcare spending, deprivati... Read More about Spending by primary care practices-does it show what we expect?.

Risk factors for scald injury in children under 5 years of age: a case–control study using routinely collected data (2013)
Journal Article
Shah, M., Orton, E., Tata, L., Gomes, C., & Kendrick, D. (2013). Risk factors for scald injury in children under 5 years of age: a case–control study using routinely collected data. Burns, 39(7), https://doi.org/10.1016/j.burns.2013.03.022

Scald injury is common, accounting for half of all burns in pre-school children. Most scalds are preventable and health professionals can play an important role in targeting interventions to those at greatest risk. However, the potential for routinel... Read More about Risk factors for scald injury in children under 5 years of age: a case–control study using routinely collected data.